Cannabinoid receptor type 1
Jacob, Wolfgang (2007): Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality. Dissertation, LMU München: Fakultät für Biologie
... In two single-cell recording studies, a high spatial and temporal precision of endocannabinoid action onto GABAergic interneurons could be demonstrated. As stated above, a brief stimulus train, that did not induce LTP ...
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The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health
... the cannabinoid system in the regulation of bone maintenance by investigating the cannabinoid system during MSC osteogenic ...CB 1 receptor is induced during osteogenic differentiation and ...
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Lower circulating endocannabinoid levels in children with autism spectrum disorder
... CB 1 R, CB 2 R : Cannabinoid receptor type-1, type-2; CBCL: Child Behavior Checklist; CGI-S : Clinical global impression- severity; DAGL: Diacylglycerol lipase; DSM-5: Diagnostic ...
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MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2.
... either 1 h or 1-4 day post-training, the SAMP8 + miR-139 group exhibited a much weaker preference for the novel object than the SAMP8 + miR-con group, while the SAMP8 + anti-miR-139 group exhibited a normal ...
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Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis
... The cannabinoid system (CS) is implicated in the regulation of hepatic fibrosis, steatosis and inflammation, with cannabinoid re- ceptors 1 and 2 (CB1 and CB2) being involved in regulation of pro- ...
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18F-MK-9470 PET imaging of the type 1 cannabinoid receptor in prostate carcinoma: a pilot study
... F-MK-9470 uptake over time. Muscle uptake of 18 F-MK-9470 was used as reference for non-specific binding. Magnetic resonance imaging (MRI) was used as anatomical reference and for delineating intraprostatic tumours. ...
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Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant
... a cannabinoid-1 receptor blocker that induces weight loss and improves the cardiovascular risk profile, glycemia and insulin sensitivity in diabetic subjects ...oid type 1 (CB1) ...
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Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis
... The role of DA in the control of striatal CB1R function has already been reported in previous studies, showing that in vivo facilitation of DA release with cocaine enhances the sensitivity of these receptors [13], while ...
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Original Article Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi
... and were approved by the Fourth Military Medical University Animal Care Committee. In addition, all efforts were made to minimize ani- mal suffering. Animals were assigned to experi- mental and control groups. ...
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Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study
... C]PK11195 in the cerebral cortical region in 15-week-old SAMP10 mice (Figs. 1 and 2b; Additional file 1: Figure S1C, D). Although there was no significant difference, the SUVRs of [ 11 C]NE40 of 15- ...
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The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors
... The crucial need to use effort-based paradigms to define the neurobiological bases of exercise motivation led us to develop an operant conditioning protocol in which NP responding under FR/PR schedules of reinforcement ...
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Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
... Cruz, 1:200) and rabbit anti-cadherin polyclonal antibody (Santa Cruz, ...Cruz, 1:200), goat anti-GAPDH polyclonal antibody (Santa Cruz, 1:200) and rabbit anti-calreticulin poly- clonal antibody ...
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Cannabinoid receptor type-2 stimulation, blockade, and deletion alter the vascular inflammatory responses to traumatic brain injury
... (Ki = 3.4 nM), in water-soluble emulsion Tocrisolve TM 100 (Tocris Catalog Number 1684) has appoximately 200- fold selectivity over CB1 receptors. The times for repeated intraperitoneal (ip) injections of 0-1966 (5 ...
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Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
... as type 2 diabetes and cardiovascular diseases is ...a cannabinoid 1 receptor (CB1R) inverse agonist, was one of the fi rst drugs that reached the European market to treat ...
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Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats
... and type of agonist for CB1 and CB2 receptors, however, these doses and types may not produce the maximal effect on the bladder of ...CB receptor expression in tissues de- pends on the availability of ...
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Abstract
... Even though the etiology of multiple sclerosis is still unclear, scientists suppose that disorders in the inflammatory reaction and unbalanced endoge− nous cannabinoid levels are causes of it [20]. In the opinion ...
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Mass Spectrometric Analysis of the Endogenous Type I Interleukin 1 (IL 1) Receptor Signaling Complex Formed after IL 1 Binding Identifies IL 1RAcP, MyD88, and IRAK 4 as the Stable Components
... IL-1 receptor was not ...the receptor complex. Both proteins bound rap- idly to the receptor upon IL-1 stimulation and remained asso- ciated with the complex for at least 1 ...
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
... antibodies (1:250) were applied in 5% milk in PBST: anti- BMPR2 C-terminal domain (BD Biosciences, 612292), anti-phosphorylated SMAD1, 5, and 8 (Cell Signaling 9516 and 13820), anti-SMAD1 (Cell Signaling 6944), ...
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Microinjection of WIN55,212-2 as a Cannabinoid Agonist into the Basolateral Amygdala Induces Sensitization to Morphine in Rats
... CB1 receptor agonist, animals received in sep- arate groups different doses of WIN55, 212-2 ...(0.5, 1, 2 and 4 ...Figure 1] showed that mi- croinjection of different doses of WIN55, 212-2(1, ...
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Anti inflammatory effects of N acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX 2 dependent manner
... LF-PA0021, 1:2000), poly(ADP-ribose) polymerase (PARP) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) (Cell Signaling, Leiden, Netherlands, #9542 and #2118, ...8.0), 1 mM EDTA, 0.5 mM EGTA, 1 % ...
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