Cannabinoid receptor type 2
Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity
... that cannabinoid receptor type 2 (CB2R) can mediate anti-inflammatory and immunomodulatory effects in part by controlling microglial ...
15
MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2.
... wild type and mutant CB2 ...mutant type 3'-UTR CB2, along with miR-139, anti-miR-139, or control ...CB2, cannabinoid receptor type 2; GAPDH, Glyceraldehyde 3-phosphate ...
12
Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study
... Endocannabinoid receptor type 2 (CB2) has recently been considered to be an alternative method for target- ing activated microglia using PET ...endo- cannabinoid system in the central nervous ...
10
In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study
... endocannabinoid receptor type 2 (CB2) has recently been considered to be an alternative method for targeting activated microglia using PET ...
9
Cannabinoid receptor type-2 stimulation, blockade, and deletion alter the vascular inflammatory responses to traumatic brain injury
... agonist JWH-133 (n = 3) and 0-1966 (n = 4) or vehicle (n = 9) and compared to wild-type CCI mice (n = 8). Controls underwent all surgical procedures including an equal time of isoflurane exposure, buprenorphine ...
10
Original Article Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway
... CB 2 agonist markedly decreased the MDA level in infarcted heart [25], which is consistent with our results that activation of CB 2 receptor reduced lung MDA level and ele- vated SOD activity in LIRI ...
10
The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health
... 1 receptor during the osteogenic differentiation of MSCs har- vested from adult Wistar ...1 receptor is increased during MSC osteogenic dif- ferentiation and is essential for the survival of differentiated ...
9
Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant
... CB1 receptor antagonists impact patient’s diets and to ascertain whether further research on CB1 receptor antagonists and indeed other anti-obesity medication on dietary composition is ...latter type ...
6
Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis
... The cannabinoid system (CS) is implicated in the regulation of hepatic fibrosis, steatosis and inflammation, with cannabinoid re- ceptors 1 and 2 (CB1 and CB2) being involved in regulation of pro- ...
10
18F-MK-9470 PET imaging of the type 1 cannabinoid receptor in prostate carcinoma: a pilot study
... the type 1 cannabinoid (CB1R) and type 2 cannabinoid (CB2R) ...factor receptor (pEGFR) expression in PCa ...reducing cannabinoid metabol- ism and tumour proliferation was ...
11
Jacob, Wolfgang (2007): Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality. Dissertation, LMU München: Fakultät für Biologie
... olfactory cues. We used four different sets of objects that were: (1) A cone made of aluminium (height: 12 cm x diameter: 6 cm), (2) a light bulb on a plastic socket (9 cm x 4 cm), (3) a flask made from yellow ...
156
Lower circulating endocannabinoid levels in children with autism spectrum disorder
... CB 2 R : Cannabinoid receptor type-1, type-2; CBCL: Child Behavior Checklist; CGI-S : Clinical global impression- severity; DAGL: Diacylglycerol lipase; DSM-5: Diagnostic and ...
11
Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats
... and type of agonist for CB1 and CB2 receptors, however, these doses and types may not produce the maximal effect on the bladder of ...CB receptor expression in tissues de- pends on the availability of ...
7
The cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins
... vanilloid receptor type 1 (TRPV1) [11] and the G pro- tein-coupled receptor 55, also known as GPR55 ...many cannabinoid-related compounds have little if any affinity for either of the two ...
16
Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis
... of CB2R modulation on survival and other parameters in experimental sepsis induced by cecal ligation and punc- ture (CLP) using CB2R knockout mice. These studies reported opposing results. In one case, CB2R knockout mice ...
11
Interaction Between L-Type Calcium Channels and Antagonist of Cannabinoid System on Anxiety in Male Rat
... dependent N-acyltransferase (NAT) (81). NAT controls the rate-limiting step in anandamide synthesis (82). In amygdala kindling, which was considered as a chronic model of seizure, the cannabinoid receptor ...
7
Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
... CB 2 on the JAK/ STAT signaling pathway in primary cultured microglial ...CB 2 agonist ...heterodimer type II cytokine receptor, the JAKs are directly activated leading to STAT1 ...
13
Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
... G-coupled receptor 55 (GPR55) was proved to be a receptor of many endocannabinoids ...transient receptor potential vanilloid type-1 and type-4 (TRPV-1, -4) [8,9], and nuclear peroxisome ...
10
Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
... as type 2 diabetes and cardiovascular diseases is ...a cannabinoid 1 receptor (CB1R) inverse agonist, was one of the fi rst drugs that reached the European market to treat ...withdrawn 2 ...
13
The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats
... and 2 (ERK1/2), in striatal neurons, which are thought to play a pivotal role in forming motor ...CB1 cannabinoid receptor agonist on L-DOPA-stimulated abnormal behavioral and signaling ...
8