cannabinoid receptors
Expression of cannabinoid receptors in human osteoarthritic cartilage: implications for future therapies
... of cannabinoid receptors may be of therapeutic value in the treatment of arthritis, 4–8 and we have previ- ously shown that synthetic cannabinoid WIN-55 reduces the expression of MMP-3 and 13 in OA ...
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<p>Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats</p>
... Figure 4A shows the effects of peripheral injection of crocin as one of the main constituents of saffron on the mechanical allodynia (Von Frey test) in the presence of Win 55-212-2 as a cannabinoid receptor ...
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Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
... of cannabinoid receptors (CB 1 and CB 2 ), we studied the potential utility of these compounds in anti–skin tumor ...of cannabinoid receptors induced the apoptotic death of tumorigenic ...
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The cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins
... many cannabinoid-related compounds have little if any affinity for either of the two known cannabinoid receptors CB1 or CB2 - suggesting that other unidentified receptors might be ...ylindole ...
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Cannabinoid receptors contribute to astroglial Ca2+ signalling and control of synaptic plasticity in the neocortex
... Figure 1. Cannabinoid receptors activate astrocytic Ca 2þ -signalling and release of gliotransmitters. (a–c) Ca 2þ -signalling activated by the bath application of 500 nM of anandamide (AEA) to neocortical ...
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Anandamide, an Endogenous Ligand of Cannabinoid Receptors, Inhibits Human Breast Cancer Cell Proliferation Through a Lipid Rafts Mediated Mechanism
... activate cannabinoid receptors, either after previous release into the extracellular space or directly moving within the cell ...exogenous cannabinoid receptor agonists, which lack such ...
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Scoring Functions and Modeling of Structure-Activity Relationships for Cannabinoid Receptors
... The main purpose of this article is to determine the correct way of ligand binding to the receptor in order to find a complex with a minimal energy. Our goal is to find the most appropriate scoring function and model for ...
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Expression of Cannabinoid Receptors in Human Osteoarthritic Cartilage: Implications for Future Therapies
... These receptors may be potential targets for arthritis ...the receptors was simi- lar across all zones of cartilage and within single cells to the same extent as ...CB2 receptors appeared to have ...
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Possible Implications of Endogenous Cannabinoid Receptors and Transient Receptor Potential Vannaloid-1 (trpv1) Receptors in Alcoholic Neuropathic Induced Pain in Wishtar Rat.
... Treatment of capsazepine (1mg/kg i.p), a selective antagonist of TRPV1, along with tetrahydrolipstatn (12mg/kg i.p), (Peng et al., 2010) an inhibitor of endogenous cannabinoid biosynthesis inhibitor potentiate the ...
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Local uterine Ang-(1–7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats
... In order to uncover this role, Ang-(1 – 7) was infused locally into one decidualized uterine horn of a pseudopregnant rat and its effects on the expression of the endocannabinoid re- cep[r] ...
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Sex differences in distribution of cannabinoid receptors (CB1 and CB2), S100A6 and CacyBP/SIP in human ageing hearts
... The key molecules implicated in the pathway of pro- grammed cell death are caspases. Some recent evidence has revealed that cannabinoids and S100A6 impact on myocar- dial cell viability by modulating the ...
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Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors?
... 32. Benito C, Tolón RM, Castillo AI, Ruiz-Valdepeñas L, Martínez-Orgado JA, Fernández-Sánchez FJ, Vázquez C, Cravatt BF, Romero J: Beta amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase ...
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Synthesis of Amphibian Alkaloids and Synthesis and Affinity of Novel Cannabinoid Receptor Ligands
... of cannabinoid receptors: CB1 and CB2. Both cannabinoid receptors are transmembrane G-protein coupled ...CB1 receptors are predominately found at nerve terminals and mediate inhibition ...
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High hopes for cannabinoid agonists in the treatment of rheumatic diseases
... [9]. Cannabinoid receptors are therefore present in the inflammatory pain pathway at both the peripheral and central (spinal and supraspinal) levels ...
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New Generation Cannabinoid Designer Drugs
... -3-yl)methanone), which seems to bind more specifically to the CB1 receptor (Wiley et al., 1998; Aung et al., 2000). The latter has been recently shown to act similarly to JWH-018, although it is less potent in inhibit- ...
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
... Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration ...C. Cannabinoid inhibition of adenylate cyclase: Relative activity of constituents and metabolites of marihuana ...of ...
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Anti inflammatory effects of N acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX 2 dependent manner
... Methods: Immunofluorescence and western blotting were used to detect cannabinoid receptors and related enzymes. Cytokines and MMP-3 were measured by ELISA. Intracellular signaling proteins were detected by ...
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Abstract
... The potential use of cannabis in the treatment of Parkinson’s disease has also been discussed recently. It was substantiated by the rich represen− tation of cannabinoid receptors in basal ganglia. The ...
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Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis
... One such target is the endocannabinoid/cannabinoid-1 receptor (endocannabinoid/CB 1 R) system. Endocannabinoids are lipid signaling molecules that act on the same cannabinoid receptors — CB 1 and CB ...
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Cannabinoid mediated short term plasticity in hippocampus
... pre-synaptic cannabinoid receptors. Here, we present a model for cannabinoid mediated short- term depression of excitation (DSE) based on our re- cently developed model for the equivalent phenomenon ...
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