Cannabinoid type 2 receptor
Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity
... In the current study, the dose and administration time of JWH133 and AM630 were selected based on previous studies [21–23] to ensure adequate functionality. How- ever, our results demonstrated no effects of the CB2 ...
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Jacob, Wolfgang (2007): Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality. Dissertation, LMU München: Fakultät für Biologie
... Makrolon Type I cage, 36 x 22 x 14 cm, with sawdust bedding material and transparent walls) on two days for 10 ...Makrolon Type II cage for about 10 s and eventually put back into the test ...than 2 ...
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Original Article Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway
... CB 2 agonist JWH133 (259869-55-1) was purchased from Cayman Chemical (Michigan, MI, USA), and it was administered intraperitoneally ...CB 2 antagonist AM630 (164178- 33-0) was purchased from Sigma ...
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Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats
... and type of agonist for CB1 and CB2 receptors, however, these doses and types may not produce the maximal effect on the bladder of ...CB receptor expression in tissues de- pends on the availability of ...
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Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis
... CB2 receptor, CB1 also has been shown to be involved in inflammatory processes ...CB2 receptor agonists and CB1 receptor antagonists exerted variable effects via different mechanisms which may in- ...
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Cannabinoid receptor type-2 stimulation, blockade, and deletion alter the vascular inflammatory responses to traumatic brain injury
... agonist JWH-133 (n = 3) and 0-1966 (n = 4) or vehicle (n = 9) and compared to wild-type CCI mice (n = 8). Controls underwent all surgical procedures including an equal time of isoflurane exposure, buprenorphine ...
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In vivo TSPO and cannabinoid receptor type 2 availability early in post-stroke neuroinflammation in rats: a positron emission tomography study
... Microglia change morphologically and functionally from their resting state to their activated state in response to several neuroinflammatory and neurodegenerative dis- eases. In other words, microglial activation ...
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The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health
... the cannabinoid system enhances the survival, migration, and chondrogenic differentiation of MSCs, which are the three key points that determine the success of cell-based tissue-engineered repair strategies ...1 ...
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Cannabinoid receptor 2 activation reduces intestinal leukocyte recruitment and systemic inflammatory mediator release in acute experimental sepsis
... of CB2R modulation on survival and other parameters in experimental sepsis induced by cecal ligation and punc- ture (CLP) using CB2R knockout mice. These studies reported opposing results. In one case, CB2R knockout mice ...
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Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study
... stroke. Type 2 endocannabinoid receptors (CB2) and translocator protein 18 kD (TSPO) are considered to reflect distinct aspects of microglia-related neuroinflammatory responses in the ...
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Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
... as type 2 diabetes and cardiovascular diseases is ...a cannabinoid 1 receptor (CB1R) inverse agonist, was one of the fi rst drugs that reached the European market to treat ...withdrawn 2 ...
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Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
... CB 2 on the JAK/ STAT signaling pathway in primary cultured microglial ...CB 2 agonist ...heterodimer type II cytokine receptor, the JAKs are directly activated leading to STAT1 ...
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Interaction Between L-Type Calcium Channels and Antagonist of Cannabinoid System on Anxiety in Male Rat
... and cannabinoid CB1 receptors are particularly well-represented in the cortex (entorhinal and cingulate), hippocampus, lateral septum, nucleus accumbens, amygdala, and peri-aqueductal gray area (PAG) ...
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Lower circulating endocannabinoid levels in children with autism spectrum disorder
... CB 2 R : Cannabinoid receptor type-1, type-2; CBCL: Child Behavior Checklist; CGI-S : Clinical global impression- severity; DAGL: Diacylglycerol lipase; DSM-5: Diagnostic and ...
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MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2.
... wild type and mutant CB2 ...mutant type 3'-UTR CB2, along with miR-139, anti-miR-139, or control ...CB2, cannabinoid receptor type 2; GAPDH, Glyceraldehyde 3-phosphate ...
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Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
... G-coupled receptor 55 (GPR55) was proved to be a receptor of many endocannabinoids ...transient receptor potential vanilloid type-1 and type-4 (TRPV-1, -4) [8,9], and nuclear peroxisome ...
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The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats
... Two experiments were conducted in this work. In the first exper- iment, the effect of acute IP administration of the CB1 recep- tor agonist WIN-55,212-2 (Cayman Chemical Company, MI, USA) on L-DOPA-treated rats ...
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Chronic, intermittent treatment with a cannabinoid receptor agonist impairs recognition memory and brain network functional connectivity
... Object recognition learning and memory is a process involving multiple items, the contextual clues surrounding them and the temporal order in each they are presented. Effective recognition memory depends on functional ...
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Cannabinoid receptor 2 expression in human proximal tubule cells is regulated by albumin independent of ERK1/2 signaling
... Our finding presented in this study, that blocking CB2 leads to an increase in albumin uptake, does not directly account for the albuminuria that is observed in animal and human models of diabetes [2]. One must ...
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
... protein receptor type 2 (BMPR2), which is essential for embry- ogenesis and has been shown to play clinically-relevant roles in pulmonary vascular homeostasis and remodeling of the postnatal skeleton ...
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