canonical pathway
Japanese Encephalitis Virus Utilizes the Canonical Pathway To Activate NF-κB but It Utilizes the Type I Interferon Pathway To Induce Major Histocompatibility Complex Class I Expression in Mouse Embryonic Fibroblasts
... Flaviviruses have been shown to induce cell surface expression of major histocompatibility complex class I (MHC-I) through the activation of NF- B. Using IKK1 ⴚ / ⴚ , IKK2 ⴚ / ⴚ , NEMO ⴚ / ⴚ , and IKK1 ⴚ / ⴚ IKK2 ⴚ / ⴚ ...
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Role of Wnt canonical pathway in hematological malignancies
... dependent and b-catenin-independent signaling pathways, respectively. Here we will emphatically point out the role of Wnt canonical pathway in hematological malignancies. A simplified model of Wnt ...
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Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy
... derived aspartate to OAA, which can be used to generate malate and pyruvate. This chain of reactions occurs with assistance from other transaminases, including GLS1, GOT2, MDH1, and ME1 to increase NADPH levels and help ...
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Molecular network based analysis of the mechanism of liver injury induced by volatile oils from Artemisiae argyi folium
... from canonical information stored in the Ingenuity Knowledge ...a canonical pathway analysis was performed using the IPA compare ...the canonical pathways were determined in the IPA ...
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WNT5A transforms intestinal CD8αα+ IELs into an unconventional phenotype with pro-inflammatory features
... non- canonical signaling and can even antagonize the canonical ...non- canonical WNT-PKCα axis has prompt development of PKC inhibition in clinical ...PKCα pathway using Sorastaurin can ...
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Non canonical auxin signalling : fast and curious
... It is tempting to hypothesise that the residues necessary for IAA-dependent activity are directly involved in an auxin sensing mechanism, either by contributing directly to binding, or by contributing to a conformation ...
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The divergent TGF β ligand Dawdle utilizes an activin pathway to influence axon guidance in Drosophila
... pathfinding defects increases when animals with a single copy of the receptors Put and Babo are further depleted of Daw ligand (Table 2). Mutations in Daw and its receptors result in a similar range and penetrance of ...
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Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation
... both canonical and noncanonical ...as canonical Wnt pathway ...as canonical pathway inducers, we examined the consequences of exposing P0 hippocampal cultures to either recombinant Wnt ...
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NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro
... NF-κB pathway, while RELB, NFKB2 and NIK are mostly the protagonists of the “non-canonical” ...of canonical and non- canonical components were tested in the CCID assay but neither RELA & ...
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Mutual regulation of JAG2 and PRAF2 promotes migration and invasion of colorectal cancer cells uncoupled from epithelial–mesenchymal transition
... non-canonical pathway is CSL-independent ...the canonical Notch pathway, RAM23 region binds to CSL after the nucleus translocation of ...signaling pathway is inactivated, CSL binds to ...
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Increased resistance to proteasome inhibitors in multiple myeloma mediated by cIAP2 - implications for a combinatorial treatment
... the canonical and the non-canonical NF-κB pathway [19, ...the canonical pathway the inhibitor of IκB kinase β (IKKβ) phosphorylates the IκBs leading to proteasomal degradation, and ...
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BMP regulates regional gene expression in the dorsal otocyst through canonical and non canonical intracellular pathways
... non- canonical pathway that involves GLI3 protein processing Analysis of inner ear phenotypes in GLI mutant mice suggested that GLIR and GLIA are present in the early otocyst as reciprocal DV protein ...
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Unveiling transcription factor regulation and differential co-expression genes in Duchenne muscular dystrophy
... KEGG pathway and IPA canonical pathway ana- lysis of the DEGs revealed that pathways enriched with aberrantly regulated genes are mostly involved in the immune response ...cells pathway were ...
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Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development
... Wnt pathway, which plays a pivotal role in HSC maintenance and in the differentiation of blood cells [17, ...18]. Canonical Wnt signalling is triggered by the interaction of a soluble Wnt ligand with a ...
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TWEAK activation of the non-canonical NF- B signaling pathway differentially regulates melanoma and prostate cancer cell invasion
... Ras/Raf/MEK/ERK pathway [21, 64], the PI3K/ Akt pathway [41], and both the canonical and non- canonical NF-κB pathways ...with canonical NF-κB pathway ...NF-κB pathway ...
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Rehman, Michael (2011): Analysis of endocytosis at eisosomes. Dissertation, LMU München: Fakultät für Biologie
... composition of the plasma membrane, nutrient uptake and regulation of cell signaling‟ (Ayscough, 2005). The word complex in this definition says that it is not a single step process but requires multiple steps for it to ...
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Regulation of Wnt/β-catenin signaling by posttranslational modifications
... -catenin pathway [150]. How canonical Wnt signaling regulates Gsk3 to inhibit β -catenin proteolysis remains largely ...Wnt pathway is intact in GSK3 α / β 21A/21A/9A/9A knockin embryonic stem (ES) ...
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Next-Generation mRNA Sequencing Reveals Pyroptosis-Induced CD4+ T Cell Death in Early Simian Immunodeficiency Virus-Infected Lymphoid Tissues
... pyroptosis pathway were significantly upregulated, and there was a strong correlation between CD4 ⴙ T cell decrease and in- creased number of CD4 ⴙ T cells expressing activated caspase-1 protein, demonstrating ...
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Wnt signaling: a promising target for osteoarthritis therapy
... the canonical Wnt signaling pathway in chondrogenic cells ...β-catenin pathway by sclerostin (SOST) deficiency in several in vitro studies ...
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The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFκB signalling pathway
... the canonical NFκB signalling pathway, demonstrated by increased IκBα phosphorylation and p65 translocation to the nucleus, and the non-canonical NFκB signalling pathway, shown by the ...
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