Cap-dependent translation initiation
Dengue Virus Utilizes a Novel Strategy for Translation Initiation When Cap-Dependent Translation Is Inhibited
... undergo translation in a cap-dependent ...and translation are not affected under conditions that inhibit cap-depen- dent translation by targeting the cap-binding protein ...
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The 3′ Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA
... ⬘ cap structure was combined with the 3 ⬘NCR, translation was increased by more than 3 logs, suggesting a strong synergic interaction between the 5 ⬘ cap and the 3⬘NCR ...that translation ...
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Cap-Independent Translation Conferred by the 5′ Leader of Tobacco Etch Virus Is Eukaryotic Initiation Factor 4G Dependent
... of cap-independent translation in ...enhance cap-independent translation in vivo but not in vitro (31), suggesting the possibility that a factor required for the function of the TEV leader ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... the initiation factors involved in the cap-dependent translation initiation may also be used in the internal initiation would signify that picornaviruses have not developed a new ...
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Cap dependent translation contributes to resistance of myeloma cells to bortezomib
... eukaryotic translation initiation factor 4F (eIF4F) complex on the 5' m7 GpppN cap structure of ...the cap binding protein eIF4E , the scaffold protein eIF4G and the ATP- dependent ...
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Activation of Cap-Dependent Translation by Mucosal Human Papillomavirus E6 Proteins Is Dependent on the Integrity of the LXXLL Binding Motif
... of cap- dependent ...translation initiation. mTORC1 also phosphorylates the eukaryotic translation initiation factor 4E (eIF4E) binding protein 1 ...the translation ...
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HIV- 1 Protease Inhibits Cap- and Poly(A)-Dependent Translation upon elF4GI and PABP Cleavage
... the initiation of translation in HeLa cells ...additional translation factor to abolish protein ...cellular translation, perhaps due to eIF4GI and PABP cleavage since both factor are essential ...
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Activity of the Hepatitis A Virus IRES Requires Association between the Cap-Binding Translation Initiation Factor (eIF4E) and eIF4G
... support translation dependent on the HAV ...GpppG cap analogue, which binds to eIF4E and prevents its interaction with the capped 5⬘ ends of mRNAs that are trans- lated by the scanning ...has ...
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Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding
... eIF4E cap binding in a manner that is dependent on RNA binding by eIF4G (4, ...the cap, eIF4E ...enhanced cap or poly(A) ...on initiation not acting exclu- sively via cap binding ...
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Alpha/Beta Interferon Inhibits Cap-Dependent Translation of Viral but Not Cellular mRNA by a PKR-Independent Mechanism
... novo initiation of translation by RNA that enters across the cytoplasmic membrane ...the translation of invading mRNAs by ⬎10-fold while preserving the translation of nuclear transcribed host ...
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The 5′ Untranslated Region of the Human T-Cell Lymphotropic Virus Type 1 mRNA Enables Cap-Independent Translation Initiation
... alternative initiation has been proposed to allow the viral mRNA to bypass the constraints of global cellular translational repression that results from the inhibition of cap-dependent ...
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Transcription-Coupled Translation Control of AML1/RUNX1 Is Mediated by Cap- and Internal Ribosome Entry Site-Dependent Mechanisms
... directs cap-dependent ...some translation of the downstream LUC cistron; however, insertion of a hairpin structure in front of the first cistron diminished the translation of both CAT and LUC ...
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<p>INPP4B promotes colorectal cancer cell proliferation by activating mTORC1 signaling and cap-dependent translation</p>
... inhibiting cap-dependent translation can effectively suppress the proliferation and migration of CRC cells, 6,7 suggesting that deregulated cap- dependent translation contributes ...
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Vaccinia Virus Protein Synthesis Has a Low Requirement for the Intact Translation Initiation Factor eIF4F, the Cap-Binding Complex, within Infected Cells
... the cap-binding complex eIF4F, on the transla- tion of reporter gene mRNAs and vaccinia virus mRNAs in vaccinia virus-infected ...the cap-dependent expression of GUS from the plasmid construct was ...
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RNA-binding proteins impacting on internal initiation of translation
... of translation initiation. Two basic mechanisms govern translation initiation in eukaryotic mRNAs, the cap-dependent initiation mechanism that operates in most mRNAs, and ...
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RNA-binding proteins impacting on internal initiation of translation
... of translation initiation. Two basic mechanisms govern translation initiation in eukaryotic mRNAs, the cap-dependent initiation mechanism that operates in most mRNAs, and ...
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The Cap-Binding Translation Initiation Factor, eIF4E, Binds a Pseudoknot in a Viral Cap-Independent Translation Element
... Eukaryotic initiation factor eIF4E performs a key early step in translation by specifically recognizing the m 7 GpppN cap structure at the 5 0 end of cellular ...0 cap and thus bypass eIF4E. ...
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Activation of AP-1-Dependent Transcription by a Truncated Translation Initiation Factor
... multisubunit translation factor, might also act to modulate AP-1-dependent transcription is an intriguing one, but at this stage it is unclear whether the activation of Pap1 by Int6CT represents a normal ...
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The adenovirus tripartite leader may eliminate the requirement for cap-binding protein complex during translation initiation.
... Translation of mRNAs encoding adenovirus DBP and protein IX, which do not contain the tripartite leader, was inhibited by infection with wt poliovirus (lane A/P), but not by the poliovir[r] ...
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Position-dependent ATT initiation during plant pararetrovirus rice tungro bacilliform virus translation.
... downstream translation, while the same or a very similar sORF had only a moderate inhibitory effect when starting at sites that are reached by scanning ...and/or initiation has been described for a CTG ...
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