Capan-1
Epidermal growth factor mediates detachment from and invasion through collagen I and Matrigel in Capan-1 pancreatic cancer cells
... in Capan-1 cells occurred with collagen I and Matrigel, and not with other extracellular matrix ...in Capan- 1 cells, although in that study, the de-adhesion response to EGF in ...
13
Glucose specific regulation of aldose reductase in capan 1 human pancreatic duct cells In vitro
... Impaired pancreatic duct secretion is frequently observed in insulin-dependent diabetes mellitus (IDDM), although the cellular mechanism(s) of dysfunction remains unknown. Studies in other tissues have suggested that a ...
9
HE4 overexpression decreases pancreatic cancer Capan-1 cell sensitivity to paclitaxel via cell cycle regulation
... the ovarian cancer cell line SKOV3 [37]. The common involvement of WAP domain factors in drug sensitivity points to the possibility that these effects could be medi- ated by the protease inhibitor activity. In this ...
13
Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles
... Nuclear DAPI staining was performed in the present study to explore the mechanism of the distinct improvement in anticancer activity induced by synergism between MNP- Fe 3 O 4 and GA. To confirm the existence of ...
7
Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers
... microdissected specimen of the recurrent tumor was hemizygous at each SNP, reflecting loss of heterozygosity of BRCA2 in the tumor. However, in the same tumor sample, both sequences of BRCA2.6174delT and wild-type BRCA2 ...
43
Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells
... and MUC4 knockdown results in decreased HER2 signaling and cell proliferation [23–25]. To elucidate the HER2 independent mechanism in the regulation of pancreatic cancer cell proliferation, two aggressive pancreatic ...
15
MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism
... in capan-1 cells were carried out by CRISPR/Cas9 system ...Briefly, capan-1 PDAC cells were transfected with MUC16 guideRNA (5’-AACACACTCGATGGCGACTC-3’, targeting DNA within the third exon) ...
15
The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2
... in CAPAN-1 and CAPAN-2 cells led to an increased sensitivity to gemcitabine and an increased resistance to irinotecan/SN-38 both in vitro and in vivo (subcuteanous xenografts) This was correlated to ...
15
Identification of PAM4 (clivatuzumab)-reactive epitope on MUC5AC: A promising biomarker and therapeutic target for pancreatic cancer
... including Capan-1, BxPC-3, and CFPAC-1; (ii) MUC5AC-specific siRNA prominently reduced the expression of both MUC5AC and PAM4-antigen in CFPAC-1 cells; (iii) PAM4 preferentially binds to the ...
12
Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-θ activation
... To investigate the effects of the antagonism of EP2/ EP4-mediated cellular signaling on growth factor receptor- mediated growth stimulation, we treated cells with EP2/EP4 antagonists, i.e., AH6809/GW627368X, and assessed ...
16
<p>Paeonol Inhibits Pancreatic Cancer Cell Migration and Invasion Through the Inhibition of TGF-β1/Smad Signaling and Epithelial-Mesenchymal-Transition</p>
... and Capan-1 cells were treated with 100 or 150μΜ of ...and Capan-1 cells migration were assessed by restoring scratches and the reduction in the area of the initial scratches were ...and ...
11
Mesothelin regulates growth and apoptosis in pancreatic cancer cells through p53-dependent and -independent signal pathway
... and Capan-2, Capan-1 and MIA PaCa-2 cell ...AsPC-1, Capan-2 and Capan-1 cells with rich mesothelin level, and mesothelin was overexpressed in the HPAC and Capan-2 ...
14
Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression
... Capan-1 and MIAPaCa-2 cell lines were purchased from American Type Culture Collection (ATCC) (Manassas, VA, USA). Both cell lines were maintained in Dulbecco’s modification of Eagle’s medium supplemented ...
11
Bioinformatics analysis combined with experiments to explore potential prognostic factors for pancreatic cancer
... transition of the mitotic cell cycle, the p53 signaling path- way, and so on. DLGAP5 was significantly related to the p53 pathway. After we knocked out DLGAP5 in Capan-2 and SW1990 cells, the protein expression ...
13
Inhibition of integrin αVβ6 changes fibril thickness of stromal collagen in experimental carcinomas
... Denmark). Capan-2 showed a 100% match, whereas KAT-4, as expected [28], matched with HT-29 although alleles D13S317:12 and TH01:9 were ...and Capan-2 cells were grown in McCoy’s 5A medium with GlutaMax ...
11
Comprehension Strategy Instruction and Iranian High School EFL Learners' Reading Anxiety and Reading Comprehension
... Throughout the last few decades, cognitive variations in learning a second/foreign language have become increasingly significant in learning/teaching a foreign language. Despite the fact that all language learners are ...
23
Social Connectedness and Flourishing: The Mediating Role of Hopelessness
... Flourishing: Flourishing was measured with the Flourishing Scale (FS) developed by Diener and colleagues [3]. The FS consists of eight items. Each item was answered on a 7-point Likert scale ranging from 1 ...
8
Anti bacterial activity of intermittent preventive treatment of malaria in pregnancy: comparative in vitro study of sulphadoxine pyrimethamine, mefloquine, and azithromycin
... Malaria in pregnancy is associated with low birth-weight [1-3], pre-term delivery [4] and maternal anaemia [5] and is therefore an important cause of maternal, perina- tal, and neonatal morbidity and mortality in ...
5
CECA Comite Consultatif manual. Douzieme edition, fevrier 1965 = ECSC Consultative Committee handbook. Twelfth edition, February 1965
... Los Commissions Pormanontes élisant leurs présidents pour la périoda du 15.1.1964 au 14.1.1965,oommo suit : Commission Objootifs Généraux : GARD~~, Paul Commission Marché ot Prix : CAPAN[r] ...
56
1 Benzylimidazolium hexafluorophosphate–1 benzylimidazole (1/1)
... solution (50 ml) of 1-benzylimidazolium chloride (2.000 g, 10.3 mmol). A pale yellow precipitate formed immediately, which was collected by filtration, washed with small portions of methanol, and dried in a vacuum ...
7