Carbapenem Resistance
A systematic review: the current status of carbapenem resistance in East Africa
... CHDL: carbapenem hydrolyzing class D beta lactamase; CMY: cephamycins; CP: carbapenemase producing; CR: carbapenem resistance; CRE: carbapenem resistant Enterobacteriaceae; CTX: cephotaxime ...
9
Characterization of a Nosocomial Outbreak Caused by a Multiresistant Acinetobacter baumannii Strain with a Carbapenem Hydrolyzing Enzyme: High Level Carbapenem Resistance inA baumannii Is Not Due Solely to the Presence of β Lactamases
... Detection of the OXA-24 gene in the IMRAB A. baumannii strains. To deter- mine the presence or absence of the OXA-24 gene in different A. baumannii strains and to study their putative role in carbapenem ...
7
Emergence and Rapid Spread of Carbapenem Resistance during a Large and Sustained Hospital Outbreak of MultiresistantAcinetobacter baumannii
... 1997, carbapenem-resistant (CR) ...of carbapenem resistance was not by the selection of resistant mutants but was by the introduction of two new epidemic clones that were different from those ...
10
Prevalence of Carbapenem Resistance in Acinetobacter baumannii Isolates from Burn and Non-Burn Patients in Tehran
... of resistance mechanisms to all existing antibiotic classes including active drug efflux, modification of drug target sites and most importantly, enzymatic inactivation of the antimicrobial agents ...of ...
5
Prevalence of a carbapenem resistance gene (KPC), vancomycin resistance genes (van A/B) and a methicillin resistance gene (mecA) in hospital and municipal sewage in a southwestern province of Saudi Arabia
... a carbapenem-resistance gene and a methicillin-resistance gene in the hospital and munici- pal sewages in a southwestern province of Saudi Arabia that were previously not ...more resistance ...
6
Rapid Identification of Five Classes of Carbapenem Resistance Genes Directly from Rectal Swabs by Use of the Xpert Carba R Assay
... of carbapenem-nonsusceptible organisms by culturing a 100- l aliquot of the enrichment broth on a MacConkey agar plate (Remel, Lenexa, KS, USA) with a 10- g meropenem disk placed in the center of the plate ...
8
Anatomic, Geographic, and Taxon Specific Relative Risks of Carbapenem Resistance in the Health Care System of the U S Department of Defense
... 14). Carbapenem resistance was defined as being resistant to ertapenem, doripenem, meropenem, or imipenem (for fermenters) or to doripenem, imipenem, or meropenem (for nonfermenters) according to prevailing ...
6
Low Prevalence of Carbapenem Resistance in Clinical Isolates of Extended Spectrum Beta Lactamase (ESBL) Producing Escherichia coli in North Central, Nigeria
... Extended Spectrum Beta Lactamase (ESBL) producing Escherichia coli is a global cause of life threatening infections. We determined the presence of ESBL and carbapenemase production in clinical isolates of E. coli and ...
12
Fast and expensive (PCR) or cheap and slow (culture)? A mathematical modelling study to explore screening for carbapenem resistance in UK hospitals
... Carbapenemase-producing carbapenem-resistant Entero- bacteriaceae (CP-CRE) are effectively a sub-population of CRE which represent a further threat, because the genes encoding the mechanisms of resistance ...
11
Carbapenem resistance, inappropriate empiric treatment and outcomes among patients hospitalized with Enterobacteriaceae urinary tract infection, pneumonia and sepsis
... between carbapenem-resistance, choice of inappropriate empiric therapy (IET), and key hospital outcomes, we conducted a cohort study of patients admitted to the hospital with community- onset urinary tract ...
13
Epidemiology of Klebsiella pneumoniae bloodstream infections in a teaching hospital: factors related to the carbapenem resistance and patient mortality
... however, carbapenem resistance was not found to be an independent predictor of mortality, as previously reported [44], but such trend was ob- served, which may be explained by a relatively small sample ...
12
Characterization of a Large Outbreak by CTX M 1 Producing Klebsiella pneumoniae and Mechanisms Leading to In Vivo Carbapenem Resistance Development
... whether carbapenem resistance was caused by alterations of the outer membrane permeability, we analyzed the outer membrane proteins of susceptible and re- sistant pairs of ...the carbapenem-sus- ...
7
Study of Phenotypic and Genotypic Characterisation of Klebsiella Species Isolated from Wound Infection with Special Reference to Carbapenem Resistance
... are resistance to cephamycins and ther are not susceptible to β lactam ...of resistance are seen in Enterobacter cloacae, Citrobacter freundii, Serratia marcescens indole- positive Proteus ...
167
Prevalence and genotypic relatedness of carbapenem resistance among multidrug-resistant P. aeruginosa in tertiary hospitals across Thailand
... The susceptibility of P. aeruginosa clinical isolates was confirmed in the research laboratory by the disc diffu- sion method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines [17]. All ...
7
Bibliometric analysis of global scientific research on carbapenem resistance (1986–2015)
... to carbapenem resistance were used in Scopus ...on carbapenem resistance were published in Antimicrobial Agents and Chemotherapy ...on carbapenem resistance in the past few ...
11
Prevalence of Acinetobacter baumannii in Saudi Arabia: risk factors, antimicrobial resistance patterns and mechanisms of carbapenem resistance
... of resistance and severity of ...elevated resistance rate among the pathogens isolated from patients with malignancies rec- ommends testing for antimicrobial sensitivity prior to starting antimicrobial ...
12
Evaluation of carbapenem resistance using phenotypic and genotypic techniques in Enterobacteriaceae isolates
... test, carbapenem inhibition zone diameter and MIC values are considered sufficient [4] and valuable for the determination of KPC, OXA and MBL enzymes in laboratories in which dilution techniques cannot be ...
6
The influence of carbapenem resistance on mortality in solid organ transplant recipients with Acinetobacter baumanniiinfection
... Fisher’s exact tests were used to analyze categorical vari- ables. Potential associations of the study variables with the outcomes were explored by univariate and multivari- ate analyses in logistic regression models. ...
8
Carbapenem Resistance Pattern of Multiple Drug-Resistantand Extended-Spectrum Beta-Lactamase-Positive Klebsiella pneumonia in Isfahan
... Antimicrobial Resistance Epidemiology (ICARE) surveillance program ...increased resistance to this class of antibiotics has left no effective drug in the health care system ...of resistance may be ...
5
Molecular Epidemiology of Sequential Outbreaks of Acinetobacter baumannii in an Intensive Care Unit Shows the Emergence of Carbapenem Resistance
... of resistance to amikacin (8, 28) or carbapenems (3, 6, 10, 16, 25) have been reported during hospital outbreaks of multidrug-resistant ...of resistance to amikacin and carbapenems in ...
8