Carbonic anhydrase IX
High expression of carbonic anhydrase IX is significantly associated with glandular lesions in gastroesophageal junction and with tumorigenesis markers BMI1, MCM4 and MCM7
... Conflicting results, ranging from 0 to 100 %, have also been published for CA9 expression in gastric adenocar- cinoma [41–43]. In our study, the rate of high CA9 expression was very high in esophageal adenocarcinoma (90 ...
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Imaging of carbonic anhydrase IX with an 111 In-labeled dual-motif inhibitor
... of carbonic anhydrase IX (CAIX) [7], a membrane-associated enzyme responsible for catalyzing the reversible hydration of carbon dioxide to a bicarbonate anion and a proton [8, ...
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Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro
... complete. Carbonic anhydrase IX (CA IX) is a cell surface antigen characterized by hypoxia-induced expression in many solid ...CA IX-directed immunoliposomes for targeted delivery of ...
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Sulfonamide derivative targeting carbonic anhydrase IX as a nuclear imaging probe for colorectal cancer detection in vivo
... Hypoxic microenvironment is a common situation in solid tumors. Carbonic anhydrase IX (CA9) is one of the reliable cellular biomarkers of hypoxia. The role of CA9 in colorectal cancer (CRC) remains ...
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Past, Present, and Future: Development of Theranostic Agents Targeting Carbonic Anhydrase IX
... resistance. Carbonic anhydrase IX (CA-IX) has been advocated as an attractive diagnostic and therapeutic biomarker for targeting hypoxia in solid ...
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Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors
... Regions of hypoxia are frequently present in tumors and profoundly influence the biology of cancer and its response to therapies [9, 10]. Classically, a high rate of cancer cell proliferation combined with structural ...
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Original Article Oncogenic roles of carbonic anhydrase IX in human nasopharyngeal carcinoma
... Abstract: Carbonic anhydrase IX (CA IX), a hypoxia-inducible protein in tumors, has been shown to be valuable for the prognosis of nasopharyngeal carcinoma ...CA IX has been not ...
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Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer
... Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer Volk[r] ...
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SCREENING OF UNIQUE BINDING SITE SPECIFIC LIGAND FOR CARBONIC ANHYDRASE IX
... termed Carbonic Anhydrase IX ...while Carbonic Anhydrase II Inhibitor (PDB ID- 2X7T) was found to be the best fit for cavity ...
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Carbonic anhydrase IX is a marker of hypoxia and correlates with higher Gleason scores and ISUP grading in prostate cancer
... CA IX and HIF-1α in comparison to grade groups ...CA IX and HIF- 1α, and Gleason (pattern and score) and ISUP grading was statistically significant (p < ...CA IX expression ...CA IX ...
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Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma
... CA IX inhibitor sup- pressed cell proliferation, migration, and ...CA IX inhibitors may be beneficial as combination drugs in the treatment of ...CA IX as a bio- marker and to evaluate the ...
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Tumor-targeted Dual-modality Imaging to Improve Intraoperative Visualization of Clear Cell Renal Cell Carcinoma: A First in Man Study
... recognizes carbonic anhydrase IX (CAIX) that has been used extensively to target clear cell RCC (ccRCC), since more than 95% of ccRCC express CAIX ...
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Expression of hypoxia inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast
... of carbonic anhydrase 9 (CA9) gene expression was found to be dependent on HIF-1 α ...gene, carbonic anhydrase IX (CAIX), catalyzes the hydration of carbon dioxide to carbonic ...
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Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade
... CAIX: carbonic anhydrase IX; CAR : chimeric antigen receptor; CCK: cholecystokinin; CSF1: colony-stimulating factor 1; CSF1R: colony-stimulating factor 1 receptor; CR: complete response; CTLA-4: ...
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Cu]XYIMSR-06: A dual-motif CAIX ligand for PET imaging of clear cell renal cell carcinoma
... Pairwise comparison of 89Zr- and 124I-labeled cG250 based on positron emission tomography imaging and nonlinear immunokinetic modeling: in vivo carbonic anhydrase IX receptor binding and[r] ...
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Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer
... Cancer-associated hypoxia switches cell metabolism towards increased production of acidic metabolites. However, tumor cells have to adapt to hypoxia and acid- osis in order to survive. CAIX is a membrane-bound protein ...
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The role of cancer associated fibroblasts in esophageal cancer
... CA IX: carbonic anhydrase IX; CKI: cyclin-dependent kinase inhibitor; COX: cyclooxygenase; DFS: disease free survival; EMT: epithelial-mesenchymal transition; EAC: esophageal adenocarcinoma; ...
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Polyhydroxyalkanoate granules : surface protein topology and rational design of functionalised biobeads : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Microbiology at Massey University, Manawatu, New Zealand
... purification ability of ZZ-inserted PHA beads. 164 Figure 6.1: Granule-associated proteins profiled by SDS-PAGE. 182 Figure 6.2: Carbonic anhydrase activity assay showing the decrease in reaction time taken ...
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Carbonic anhydrase in the adult mosquito midgut
... quantitated CA content in the anterior and posterior midgut of adult males and females from these species using the 18O isotope exchange method coupled to mass Key words: mosquito, carbo[r] ...
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QSAR and docking studies on inhibition of carbonic anhydrase tumor- associated isoenzyme IX with heterocyclic sulfonamides as cytotoxic agents
... CA IX inhibitors become a good target to design new-type anticancer drug [15, 16], which encourage us to start this research to study the relationship between chemical structure and biological ...
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