carboxy-terminal
Functional Replacement of the Carboxy-Terminal Two-Thirds of the Influenza A Virus NS1 Protein with Short Heterologous Dimerization Domains
... its carboxy-terminal region (effector domain) has been reported to inhibit process- ing (24, 32) and nuclear-cytoplasmic transport of host mRNA (26), and these functions have also been suggested to play a ...
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Assembly of Spikes into Coronavirus Particles Is Mediated by the Carboxy-Terminal Domain of the Spike Protein
... teins led to the formation of particles that could be affinity isolated as expected by the MAb J1.3 against the MHV M protein ectodomain (6) as well as by the MAb WA3.10 against the MHV S ectodomain (33) but not by the ...
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The Carboxy-Terminal Domain of Glycoprotein N of Human Cytomegalovirus Is Required for Virion Morphogenesis
... after infection. In the absence of antibody, the parental virus RV-HB5 efficiently spread through the culture, and by day 14, approximately 100% of the cells were infected (Fig. 5). In the presence of antibody, the ...
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Radioimmunoassay for the carboxy terminal cross linking domain of type IV (basement membrane) procollagen in body fluids Characterization and application to collagen type IV metabolism in fibrotic liver disease
... The carboxy-terminal cross-linking domain (NCl) of type IV procollagen was isolated from human placenta and used for the production of polyclonal and monoclonal ...
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RNA Polymerase II Carboxy-Terminal Domain Kinases: Emerging Clues to Their Function
... The cloning of the largest subunit of RNA polymerase II (pol II) from mouse and Saccharomyces cerevisiae in 1985 (3, 28) revealed a remarkable and highly conserved domain known as the pol II ...
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Phosphorylation of threonine in the proline-rich carboxy-terminal region of simian virus 40 large T antigen.
... The antiserum directed against the carboxy-terminal peptide of large T antigen specifically and quantitatively removed the phosphothreonine peptide from both the tryptic and the chymotry[r] ...
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Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease
... Alzheimer’s disease (AD) is characterized by protein aggregates, i.e. senile plaques and neurofibrillary tangles. The ubiquitin-proteasome system has been proposed a role in proteolytic removal of these protein ...
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Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain
... Cellular localization of the NS4B carboxy terminal domain Since the CTD of NS4B only partially overlaps with the ER-marker, PDI (Fig. 1a), we were interested in knowing on which other membranes the NS4B-CTD ...
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Phenotypic Analysis of Schizosaccharomyces Pombe Strains bearing Site-Directed Mutations in the Carboxy Terminal Domain of the Largest Subunit of RNA Polymerase II
... Phenotypic Analysis of Schizosaccharomyces Pombe Strains Phenotypic Analysis of Schizosaccharomyces Pombe Strains bearing Site-Directed Mutations in the Carboxy Terminal Domain bearin[r] ...
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Structural and functional consequences of switching carboxy terminal domains in mouse CD200 receptors
... Cell lysates of mR4V5 transfected cells fractionated into membrane and cytosolic fractions are shown in Fig- ure 3(C). The molecular mass of mR4V5 in the mem- brane fraction was 48 kDa (Figure 3(C), lane 7) whereas the ...
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Genetic Analysis of the Carboxy-Terminal Region of the Hepatitis C Virus Core Protein
... Identification of residues in the C terminus of the core protein that are critical for infectious virus production. The C-terminal 20 to 22 amino acids of the HCV core protein are thought to function as a signal ...
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Decoding the informational properties of the RNA polymerase II Carboxy Terminal Domain
... Presentation of the Hypothesis: By formally applying the long-standing mathematical principles of information theory, I explore the hypothesis that complex post-translational modificatio[r] ...
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Functional Analysis of Carboxy-Terminal Deletion Mutants of c-Myb
... FIG. 1. Transactivation of the EW5 reporter gene by c-Myb mutants. (A) A series of deletion or insertion mutants of c-Myb expressed from a retroviral vector were assayed for transcriptional activity in QT6 cells by ...
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Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.
... and carboxy-terminal domain to map the different functional domains and to define the interrelation- ships between virion incorporation, nuclear localization, cell cycle arrest, and differentiation ...
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Functional interactions among two yeast mitochondrial ribosomal proteins and an mRNA-specific translational activator.
... carboxy-terminal amino acids. However, neither a complete deletion of PET122 nor a missense mutation in the amino-terminal part of the PET 122 protein was suppressed. This [r] ...
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Both Carboxy- and Amino-Terminal Domains of the Vaccinia Virus Interferon Resistance Gene, E3L, Are Required for Pathogenesis in a Mouse Model
... Vaccinia virus (VV) is the prototypical large double- stranded DNA virus, encoding approximately 190 genes. VV has been extensively studied as a safe alternative for a vaccine or gene therapy delivery vector (28, 29, 32, ...
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Characterization of the trans-Activation Properties of Equine Herpesvirus 1 EICP0 Protein
... The carboxy- terminal region of the HSV-1 ICP0 protein was not required for ICP0 to independently transactivate HSV-1 promoters but was required for synergy and physical association with the HSV-1 ICP4 ...
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Mapping of B-cell epitopes of the human hepatitis B virus X protein.
... The carboxy-terminal half of the HBx antigen was the most frequent target for anti-HBx antibodies in sera of patients with viral hepatitis and contained an immunodominant antigenic regio[r] ...
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The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule.
... The results of these experiments showed that mutants containing insertions or deletions in the region from amino acids 262 to 406 in the carboxy-terminal half of the protein were unable [r] ...
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elife-27283.pdf
... We were then in a position to determine the importance of the TFAM carboxy-terminal tail for DNA looping. Under conditions in which looped mtDNA molecules were prevalent in the presence of TFAM, looped ...
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