carboxypeptidase Y
Carboxypeptidase D (gp180), a Golgi-Resident Protein, Functions in the Attachment and Entry of Avian Hepatitis B Viruses
... Carboxypeptidase D (gp180), one of many candidate receptors proposed for hepatitis B viruses (HBVs), was examined and found to be the actual cellular receptor for avian HBVs. This conclusion was based on the ...
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The crystal structure and oligomeric form of Escherichia coli L,D carboxypeptidase A
... PG is continually reworked as the cell grows and divides [7-9], so that during exponential growth bacterial cells release a considerable quantity of PG break-down products into the growth medium. Some of these cell-wall ...
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Aortic carboxypeptidase–like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis
... Incidence of nonalcoholic steatohepatitis (NASH), which is considered a hepatic manifestation of metabolic syndrome, has been increasing worldwide with the rise in obesity; however, its pathological mechanism is poorly ...
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Regulation of dopamine transporter activity by carboxypeptidase E
... Association of DAT with CPE. A, Using the Yeast 2-Hybrid System 3 (Invitrogen), 1.7 × 106 independent clones of a human substantia nigra library (in pGAD10) were screened using DAT-NT, containing the amino terminus up to ...
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Silencing of carboxypeptidase E inhibits cell proliferation, tumorigenicity, and metastasis of osteosarcoma cells
... Abstract: Carboxypeptidase E (CPE), a prohormone processing enzyme, has been implicated in the progression of multiple malignancies. However, the biological role and molecular mecha- nisms of CPE in osteosarcoma ...
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Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis
... Plasma glutamate carboxypeptidase (PGCP) is a secreted protein hydrolyzing the circulating peptides in the extracellular microenvironment. In particular, PGCP liberates I-thyroxine (T4) from thyroglobulin (Tg), ...
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Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis
... The immune and coagulation systems are both implicated in the pathogenesis of rheumatoid arthritis (RA). Plasma carboxypeptidase B (CPB), which is activated by the thrombin/thrombomodulin complex, plays a pro- ...
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Engineering an efficient secretion of leech carboxypeptidase inhibitor in Escherichia coli
... leech carboxypeptidase inhibitor (LCI) in the bacterial periplasm, we compared expression of the natural and optimized gene sequences, and evaluated export efficiency of LCI fused to different signal ...
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Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies
... Background: Glutamate excitotoxicity is thought to be involved in the pathogenesis of neurodegenerative disease. One potential source of glutamate is N-acetyl-aspartyl-glutamate (NAAG) which is hydrolyzed to glutamate ...
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Characterisation of the carboxypeptidase G2 catalytic site and design of new inhibitors for cancer therapy
... enzyme carboxypeptidase G2 (CPG2) is utilized in antibody directed enzyme pro-drug therapy (ADEPT) to catalyze the formation of an active drug from an inert ...
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A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus.
... the carboxypeptidase N gene, whose localization in the human genome was not known, to 8p22-23, close to the HBV integration site ...tional carboxypeptidase N high-molecular-weight-subunit ...a ...
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Human mast cell carboxypeptidase Purification and characterization
... from carboxypeptidase A in its inability to hydrolyze des-Arg9 ...cell carboxypeptidase was similar to the composition of rat mast cell ...cell carboxypeptidase demonstrated 65% positional identity ...
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PREVALENCE OF GLUTAMATE CARBOXYPEPTIDASE II C1561T, REDUCED FOLATE CARRIER 1 A80G, AND METHIONINE SYNTHASE A2756G GENE POLYMORPHISMS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AMONG SOUTH INDIANS
... Glutamate carboxypeptidase II (GCPII), reduced folate carrier 1 (RFC1), and methionine synthase (MTR) genes involved in the folate metabolic pathway may play a key role in the pathogenesis of diabetes and its ...
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Biophysical study into the structure and substrate binding properties of peptido mimetic ligands to carboxypeptidase G2
... The members of the M20 family are known to be aminoacylases or exopeptidases, such as CPG2 (Levy and Goldman 1967). Many of these enzymes have shown potential as therapeutic agents. Succinyldiaminopimelate ...
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Carboxypeptidase D Is an Avian Hepatitis B Virus Receptor
... The receptor molecules for human and animal hepatitis B viruses have not been defined. Previous studies have described a 170 to 180 kDa molecule (p170 or gp180) that binds in vitro to the pre-S domain of the large ...
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In vivo regulation of plasminogen function by plasma carboxypeptidase B
... total carboxypeptidase and CpN in the presence of PCI accord- ing to the manufacturer’s ...total carboxypeptidase activity and the CpN activity represents activated ...
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Cloning and characterization of the novel gene for mast cell carboxypeptidase A
... cell carboxypeptidase has previously been ...cell carboxypeptidase A (MC-CPA) is a prominent secretory granule marker of mast cell differentiation and ...
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Investigations into the enzymology and biotechnology of the hyperthermophilic carboxypeptidase (PfuCP) from the Archaeon Pyrococcus furiosus
... The broad amino acid specificity and rapid digestion by PfuCP in peptide sequencing trials show promise, and high-temperature protein sequencing has now been demonstrated for the first t[r] ...
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PEP4 GENE FUNCTION IS REQUIRED FOR EXPRESSION OF SEVERAL VACUOLAR HYDROLASES IN SACCHAROMYCES CEREVISIAE
... The pep4-3 mutation results in a 90-9570 reduction in the levels of five vacuolar hydrolases in yeast, including proteinases A and B, carboxypeptidase Y , RNase(s) and t[r] ...
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Glucarpidase to combat toxic levels of methotrexate in patients
... by carboxypeptidase G2 (30 U) five minutes later, and another group received carboxypeptidase G2 ...and carboxypeptidase G2, cerebrospinal fluid levels of methotrexate decreased by greater than ...
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