Cardiac differentiation
A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors
... MESP1-derived cardiac cells ...in cardiac development, such as NKX2-5, TBX18, WT1, TCF21, TBX2, HAND2, MEF2C, ISL1, and ...of cardiac genes encoding for structural and sarcomeric proteins and ion ...
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The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing
... the cardiac proteome between OGFOD1-KO and WT, we subjected the proteins showing a significant difference to gene ontology analysis using DAVID ...and cardiac muscle contraction (Figure ...titin; ...
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Downregulation of long non-coding RNA H19 promotes P19CL6 cells proliferation and inhibits apoptosis during late-stage cardiac differentiation via miR-19b-modulated Sox6
... early cardiac-spe- cific markers (GATA4 and Nkx-2.5), cardiac contractile protein genes (α-MHC and MLC-2v) in P19CL6 cells at indicated time ...of differentiation) than those in P19CL6 cells at day 8 ...
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Topological and electrical control of cardiac differentiation and assembly
... In the context of microenvironmental control in the heart, it is necessary to mention the importance of the dynamic contractile forces that are present. Th e ECM plays a critical role in the heart cell niche during ...
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Wnt/β catenin signaling directs the regional expansion of first and second heart field derived ventricular cardiomyocytes
... each analog, we found a four- to eightfold increase in cTnT+ and a 15- to 20-fold increase in cTnT+/Ki67+ cell number (Fig. 1B,C). To further determine whether canonical Wnt signaling and β-catenin activation can promote ...
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Hsa-miR-335 regulates cardiac mesoderm and progenitor cell differentiation
... successful cardiac differentiation ...the differentiation stage which has been most affected by miR-335 expression alteration, the expression level of stage-specific markers was measured by ...as ...
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Mesenchymal stem cells from umbilical cord tissue as potential therapeutics for cardiomyodegenerative diseases – a review
... broad differentiation potential of MSC could also lead to undesirable ...osteogenic differentiation of BM-MSC within ischemic myocardium in a murine model ...certain cardiac differentiation of ...
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Long noncoding RNA Braveheart promotes cardiogenic differentiation of mesenchymal stem cells in vitro
... regulates cardiac differentiation of ESCs and PSCs [17, ...and cardiac re- ...the cardiac lineage differenti- ation of ...genic differentiation of ...
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Differentiation of human adipose-derived stem cells into cardiomyocyte-like cells in fibrin scaffold by a histone deacetylase inhibitor
... the cardiac-specific proteins can be expressed with mesenchymal stem cells (MSC) treated with 5-Aza, it seems that 5-Aza cannot be directly involved in stem cell ...diac differentiation may not be specific ...
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Myocardin is sufficient and necessary for cardiac gene expression in Xenopus
... both cardiac and smooth muscle ...and cardiac differentiation markers may be activated (Chen et ...both cardiac and smooth muscle markers ...the cardiac and smooth muscle regulatory ...
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Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells
... the cardiac differentiation potential of MSCs within the necrotic scar and whether those cells that do integrate and express markers of a myo- genic lineage contribute to functional repair ...
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Fluorescent gene reporters in human pluripotent stem cells : as model for studying human heart development and cardiomyocyte differentiation
... and/or differentiation[8, ...in cardiac conduction lineage differentiation from ...in cardiac conduction lineage differentiation, as it was previously shown that inhibition of this ...
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Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells
... the cardiac developmental process in vitro, and cardiomyocytes derived from iPSCs are a putative cell source for personalized ...and cardiac mesoderm commitment of iPSCs remain ...for cardiac ...
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Applications of Raman micro spectroscopy to stem cell technology: label free molecular discrimination and monitoring cell differentiation
... Stem cell therapy is widely acknowledged as a key medical technology of the 21st century which may provide treatments for many currently incurable diseases. These cells have an enormous potential for cell replacement ...
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Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling
... severe cardiac defects, most apparent by a strong reduction in cardiomyocyte ...of cardiac progenitor cells and their differentiation into ...cardiomyocyte differentiation defect observed in ...
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The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis
... material). Cardiac defects emerged in MZfrv mutants at an earlier stage than in zygotic frv ...Whereas cardiac fusion proceeded normally in Mfrv mutants, the medial migration of MZfrv cardiomyocytes was ...
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FoxF is essential for FGF induced migration of heart progenitor cells in the ascidian Ciona intestinalis
... An epistasis experiment was conducted in order to establish a more definitive link between FoxF gene activity and heart cell migration. As shown previously, targeted expression of the constitutively active form of Ets1/2 ...
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Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart field
... (J,K,N,O) Confocal z-stacks of pharyngeal regions in the same embryos at 72 hpf shown as merged (J,L,N,P) or single-channel (K,O) images. All five animals with PA1 photoconversion demonstrated tracing to the ipsilateral ...
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Exon skipping and gene transfer restore dystrophin expression in human induced pluripotent stem cells cardiomyocytes harboring DMD mutations
... The skeletal muscle clinical trials have benefitted from nu- merous background studies in which therapeutics have been tested in cultured muscle cells derived from DMD patients [11]. Such in vitro work has allowed the ...
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Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest
... In the present study, blood GDF-15 increased rapidly to high levels after circulation was restored; this increase was followed by a decline during the first 24 h (Additional file 5: Figure S2). Neuronal damage can be a ...
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