Cardiac Fibrosis
Cardiac fibrosis in the elderly, normotensive athlete: case report and review of the literature
... The molecular activity of angiotensin II and adrenergic stimulation involve the extracellular-signal-related kinases (ERK1/2), p38 and Jun N-terminal kinase (JNK) [13,14], leading to fibroblast activation. Inflammation ...
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Crucial Role of miR-433 in Regulating Cardiac Fibrosis
... promote fibrosis [21, ...of cardiac fibroblasts into myofibroblasts accompanied with an activation of TGF-β/Smad3 signaling ...of cardiac fibrosis needs to be further clarified through the ...
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Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice
... and degradation of the extracellular matrix (ECM) in the normal heart [4]. As the main matrix-producing cells, CFs are critically involved in all cardiac fibrotic conditions. In response to various stimuli, CFs ...
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Original Article Ets-1 upregulation mediates angiotensin II-related cardiac fibrosis
... II-induced cardiac fibrosis in ...in cardiac PAI-1 [1] and CTGF ...tissue fibrosis, the induction of these two parameters may contribute the increase in collagen content and the ratio of left ...
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Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid
... that cardiac fibrosis in diabetic car- diomyopathy is associated with a decrease in MMP-2 ex- pression/activity ...ameliorated cardiac dysfunction, decreased LV Type I and III collagen deposition, ...
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Review Article Endothelial mesenchymal transition in cardiac fibrosis
... affects cardiac function through accelerated atherosclerosis and hyper- ...of cardiac cells, inde- pendently of hypertension and ...reduce cardiac fibrosis through preventing EndMT in diabetic ...
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Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway
... these lines, we used TGF- β to induce EndMT in HUVECs. The results of this paper showed that RLX decreased the expression of vimentin but increased that of CD31, showing endothelial cells, as compared with TGF- β alone. ...
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Overexpression of Interleukin-18 Aggravates Cardiac Fibrosis and Diastolic Dysfunction in Fructose-Fed Rats
... human cardiac fibroblasts via phos- phatidylinositol 3-kinase–Akt-dependent NF-κB activation, suggesting that IL-18 in vivo may activate signaling pathways leading to cardiac ...
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Effect of dietary fat and sucrose consumption on cardiac fibrosis in mice and rhesus monkeys
... and cardiac fibrosis in ...decrease cardiac fibrosis induced by high-fat and “Western” diets ...NHPs, fibrosis was quantified in both NIA and UW LV tissue samples using Masson’s ...
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Mineralocorticoids, hypertension, and cardiac fibrosis
... only. Cardiac hydroxyproline concentration was increased considerably by Aldo and DOC, to a lesser degree by RU486, and not by ...perivascular fibrosis was noted; DOC elevated perivascular collagen ...
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LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d
... a cardiac-specific lncRNA, inhibits cardiac hypertrophy and failure by sequestering Brg1 and then preventing chromatin ...of cardiac hypertrophy through interacting with PRC2 and then inhibiting ...
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Alpha-lipoic acid attenuates cardiac fibrosis in Otsuka Long-Evans Tokushima Fatty rats
... in cardiac cell death, fibrosis, and endothelial dysfunction ...concentric cardiac hypertrophy in adiponectin-deficient mice ...rates cardiac diastolic dysfunction and fibrosis in OLETF ...
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Cardiac fibrosis: new insights into the pathogenesis
... induced cardiac fibrosis, eventually resulting in dilated cardiomyopathy ...reduced cardiac dysfunction, but exacerbated cardiac fibrosis ...in cardiac fibrosis. IL-6 ...
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Translational control of cardiac fibrosis
... We generated nucleotide-resolution translatome data during the TGFβ1-driven cellular transition of human cardiac fibroblasts to myofibroblasts. This identified dynamic changes of RNA transcription and translation ...
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Pathophysiology and therapeutic potential of cardiac fibrosis
... and fibrosis induced by TGF-β signaling are adaptive responses to acute stress [3], the inhibition of TGF-β signaling may be useful for treating cardiac fibro- ...and cardiac fibrosis but also ...
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Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells
... Drug-induced fibrosis in CM-MSC cardiac microtissues To further explore the applicability of CM-MSC cardiac microtissues to drug-induced cardiac fibrosis models, we examined reference ...
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Fibroblast specific TGF β–Smad2/3 signaling underlies cardiac fibrosis
... ing cardiac fibrosis with longstanding chronic disease ...reduce fibrosis itself without altering other growth- dependent effects of ...on cardiac fibrosis, but could also be ...
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Antifibrotic therapies to control cardiac fibrosis
... decrease cardiac fibrosis ...diac fibrosis. The mechanism is that bFGF attenuates cardiac fibroblasts to differentiate into myofibroblasts in the presence of TGFβ ...
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Ramipril attenuates lipid peroxidation and cardiac fibrosis in an experimental model of rheumatoid arthritis
... Augmented fibrosis in the heart is linked with ventricu- lar remodeling and subsequent cardiac dysfunction and is therefore a common pathological feature of many types of HF ...Traditionally, cardiac ...
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The role of the renin angiotensin system in regulating collagen deposition in the development of cardiac fibrosis
... thought that, in old age the lack of ability of the heart to hypertrophy in response to pressure overload may be due to its inability to induce c-fos expression (Isoyama et al, 1994). The other group is that of late ...
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