cardiac myocyte
Interferon Regulatory Factor 3 Is Required for Viral Induction of Beta Interferon in Primary Cardiac Myocyte Cultures
... We previously demonstrated that nonmyocarditic reoviruses induce more IFN- than do myocarditic reoviruses in primary cardiac myocyte cultures (44). This raises the intriguing possi- bility that myocarditic ...
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Portraying the effect of source influx on interdependent calcium and inositol 1,4,5−trisphosphate dynamics in cardiac myocyte
... the cardiac tissues, information processing in the brain, release of digestive enzymes by the liver ...in cardiac myocyte to understand its ...in cardiac myocyte without paying ...
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Interleukin 1 beta induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture
... Interleukin-1 (IL-1), initially called "endogenous pyrogen," is primarily known as a mediator of inflammation. However, it also plays many other diverse physiologic roles including the stimulation and inhibition ...
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Cardiac myocyte–secreted cAMP exerts paracrine action via adenosine receptor activation
... exacerbated cardiac myocyte (CM) hypertrophy and cardiac fibrosis induced by pressure overload (Supplemental Fig- ure 3, ...impaired cardiac function or cardioprotective mechanisms, ...
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Analysis of Cripto expression during mouse cardiac myocyte differentiation
... Vertebrate cardiac progenitor cells are initially allocated in two distinct domains, the first and second heart ...with cardiac myocyte ...the cardiac crescent region, known as the first heart ...
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Local InsP3 dependent perinuclear Ca2+ signaling in cardiac myocyte excitation transcription coupling
... ular myocytes are mainly in the nuclear envelope, where they associate with CaMKII, and that class II histone deacetylases (e.g., HDAC5) suppress hypertrophic gene transcription. Furthermore, HDAC phosphorylation in ...
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Reovirus Induction of and Sensitivity to Beta Interferon in Cardiac Myocyte Cultures Correlate with Induction of Myocarditis and Are Determined by Viral Core Proteins
... in cardiac myocyte cultures correlates with viral myocarditic po- tential could reflect differential induction of IFN and/or dif- ferential activation of the IFN-induced antiviral proteins ...
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A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy
... in cardiac myocyte ...neonatal cardiac myocytes results in sarcomeric reorganiza- tion and an increase in cell size that is indistinguishable from ligand-stimulated ...to cardiac ...
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A mechanistic role for cardiac myocyte apoptosis in heart failure
... massive cardiac myocyte apoptosis and rapid organismal ...of cardiac myocyte ...of cardiac myocyte apoptosis by long-term caspase inhibition prevented the develop- ment of ...
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Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy
... inhibit cardiac myocyte hypertrophy in response to other agonists such as endothelin-1 and phenylephrine, and to pressure overload, suggests that the predomi- nant mechanism of action includes mechanisms ...
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A unique pathway of cardiac myocyte death caused by hypoxia–acidosis
... of cardiac myocytes is a central feature of heart disease of both ischemic and non-ischemic origin (reviewed in Anversa and Kajstura, 1998; Kajstura et ...allow myocyte drop-out under conditions of severe ...
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Reovirus-induced acute myocarditis in mice correlates with viral RNA synthesis rather than generation of infectious virus in cardiac myocytes.
... RNA synthesis at 10 h postinfection was not a strong deter- minant of viral yield (Fig. 7), suggesting that other rate-limiting parameters of viral replication not relevant to myocarditis de- termine assembly of ...
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Dominant negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice
... in cardiac myocytes or cultured myotubes is associated with an impaired cell shortening followed by sar- comere disarray ...(18–20). Cardiac myocyte disarray also has been induced through expression ...
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Tumor necrosis factor alpha gene and protein expression in adult feline myocardium after endotoxin administration
... and cardiac myocytes in the endotoxin-treated hearts, whereas TNF alpha immunostaining was absent in the diluent- treated ...the cardiac myocyte was a source for TNF alpha production, two studies ...
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An ITAM in a Nonenveloped Virus Regulates Activation of NF-κB, Induction of Beta Interferon, and Viral Spread
... in cardiac myocytes ...primary cardiac myocyte cultures were infected at a low MOI with WT T3D, 2-YYFF, or 2-YYFF viruses and then in- cubated for 5 to 7 days to allow multiple cycles of viral ...
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A master stability function approach to cardiac alternans
... a cardiac Ca 2+ network is associated with the emergence of cardiac Ca 2+ ...earliest cardiac arrhythmias and act as precursors to more severe cardiac abnor- malities including sudden ...
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Original Article Tetramethylpyrazine confers cardioprotection against I/R injury by the Hsp70/NF-κB dependent pathway
... enhanced cardiac myocyte apoptosis following ...the cardiac myocyte in vivo and in vitro, followed by inactivation of myocardial induced I/R NF-κB and PUMA as well as reduction of IL-6, IL-1β, ...
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Dilated cardiomyopathy in transgenic mice expressing a dominant negative CREB transcription factor in the heart
... failure, cardiac dilatation, and premature ...the cardiac myocyte- specific alpha-MHC promoter develop dilated cardiomyopathy that closely resembles many of the anatomical, physiological, and ...
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A transgenic rabbit model for human hypertrophic cardiomyopathy
... comeric proteins (12–19). The phenotypes have been premature death, cardiac myocyte disarray, interstitial fibrosis, and systolic and diastolic dysfunction. How- ever, left ventricular hypertrophy, the ...
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Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II B–depleted mice
... In summary, we have demonstrated that by lowering the amount of NMHC-B mRNA and protein, we pro- duced mice that permit the study of the gradual devel- opment of defects that can serve as valuable models for human ...
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