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Cardiac myosin

Cardiac myosin-Th17 responses promote heart failure in human myocarditis

Cardiac myosin-Th17 responses promote heart failure in human myocarditis

... against cardiac myosin fragments in a response to damaged myocardium, which may promote the progression to heart failure and DCM in our human myocarditis ...

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Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice

Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice

... with cardiac myosin induces T cell–mediated myocarditis in genetically predisposed mice and serves as a model for autoimmune heart ...the myosin mole- ...between cardiac ( a -) myosin ...

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Distribution of cardiac myosin isozymes in human conduction system  Immunohistochemical study using monoclonal antibodies

Distribution of cardiac myosin isozymes in human conduction system Immunohistochemical study using monoclonal antibodies

... To determine the presence and distribution of cardiac myosin isozymes in the human conduction system, we performed an immunohistochemical study using monoclonal antibodies CMA19 and HMC1[r] ...

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Increase in cardiac myosin heavy chain (MyHC) alpha protein isoform in hibernating ground squirrels, with echocardiographic visualization of ventricular wall hypertrophy and prolonged contraction

Increase in cardiac myosin heavy chain (MyHC) alpha protein isoform in hibernating ground squirrels, with echocardiographic visualization of ventricular wall hypertrophy and prolonged contraction

... reduced cardiac output could lead to congestive ...the cardiac output was nearly 40% of the active state, suggesting an efficient pumping ...of cardiac myosin heavy-chain (MyHC) isoforms in a ...

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HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C

HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C

... A7811); cardiac myosin heavy chain [BA-G5], mouse monoclonal 1:1,000 (AbCam, ab50967); GAPDH, rabbit polyclonal 1:1,000 (Millipore, ABS16); IRDye 680RD goat anti- mouse IgG 1:5,000 (LI-COR, 926-68070); and ...

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Autoimmunity in Chagas' disease  Identification of cardiac myosin B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient

Autoimmunity in Chagas' disease Identification of cardiac myosin B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient

... recognize cardiac myosin and B13 ...human cardiac myosin HC and B13 recombinant ...against cardiac and skeletal myosin heavy chains and B13 ...of myosin recognition by T ...

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Cardiomyopathy mutations in the tail of beta cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes.

Cardiomyopathy mutations in the tail of beta cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes.

... β- cardiac myosin (MYH7) (6) cause the disease hypertrophic cardiomyopathy (HCM), a global disease that causes heart failure, first described over 50 years ago ...

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Research Progress of Cardiac Myosin Binding Protein C in Dilated Cardiomyopathy and  Other Cardiac Conditions

Research Progress of Cardiac Myosin Binding Protein C in Dilated Cardiomyopathy and Other Cardiac Conditions

... discovery, myosin-binding protein C (cMyBP-C) has become a pro- tein of interest ...of cardiac contraction during systole and complete relaxation during ...to cardiac conditions including ...

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Localization of cardiac myosin specific antibody in myocardial infarction

Localization of cardiac myosin specific antibody in myocardial infarction

... By utilizing Fab'2 fragments of antimyosin obtained by pepsin digestion of purified antibody, the ratio of uptake was increased in eight dogs to 6.1+/-0.6 in the endocardial and 3.3+/-0.[r] ...

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Novel splice donor site mutation in the cardiac myosin binding protein C gene in familial hypertrophic cardiomyopathy  Characterization Of cardiac transcript and protein

Novel splice donor site mutation in the cardiac myosin binding protein C gene in familial hypertrophic cardiomyopathy Characterization Of cardiac transcript and protein

... defined cardiac MyBP-C mutations as a possi- ble cause of ...truncated cardiac MyBP-C with disruption of the titin and myosin-binding COOH-terminal region ...the myosin- and titin-binding COOH ...

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A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart

A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart

... the cardiac-MLCK protein (Fig- ure ...of cardiac-MLCK, we gen- erated an adenovirus vector encoding ...of cardiac-MLCK in cultured neonatal rat cardiomyocytes aug- mented sarcomere organization under ...

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The protective effect of Er Xian decoction against myocardial injury in menopausal rat model

The protective effect of Er Xian decoction against myocardial injury in menopausal rat model

... (like myosin and actin), and cytoskeletal proteins (like myosin binding protein C and ...from myosin coupling its ATPase activity to its cyclic inter- action with ...actin. Myosin consists of ...

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Curcumin ameliorates experimental autoimmune acute myocarditis in rats as evidenced by decrease in thioredoxin immunoreactivity

Curcumin ameliorates experimental autoimmune acute myocarditis in rats as evidenced by decrease in thioredoxin immunoreactivity

... ameliorates cardiac myosin-induced autoimmune myocarditis in rats, as evidenced by a significant reduction of TRX immuno- reactivity, as well as, of the serum levels of both cardiac injury markers ...

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Cannabidiol Limits T Cell-Mediated Chronic Autoimmune Myocarditis: Implications to Autoimmune Disorders and Organ Transplantation

Cannabidiol Limits T Cell-Mediated Chronic Autoimmune Myocarditis: Implications to Autoimmune Disorders and Organ Transplantation

... Consistent with previous investi- gations (8,10,20,25), we found that immunization with the MyHCα 334–352 of mice resulted in severe inflamma- tory cell infiltration and necrosis on H&E-stained myocardial sections. ...

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Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease

... calcium-dependent cardiac muscle con- ...by myosin regulatory proteins (for example, myosin light chain-2 [MLC2]) in cardiac muscle remain poorly ...regulating cardiac muscle ...

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Functional analysis of the mutations in the human cardiac beta myosin that are responsible for familial hypertrophic cardiomyopathy  Implication for the clinical outcome

Functional analysis of the mutations in the human cardiac beta myosin that are responsible for familial hypertrophic cardiomyopathy Implication for the clinical outcome

... -cardiac myosin heavy chain (MHC) gene, which alter only a single amino acid residue, have been described ...-cardiac myosin heavy chain gene mutations carry greater risk of morbidity than ...

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Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function

Diabetes with heart failure increases methylglyoxal modifications in the sarcomere, which inhibit function

... mouse cardiac NTFs were observed moving over a surface of mouse cardiac myosin adhered to a glass coverslip within a 20-μl, nitrocellulose-coated flow cell at 22°C, has been described previously ...

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Incorporating development of a patient-reported outcome instrument in a clinical drug development program: examples from a heart failure program

Incorporating development of a patient-reported outcome instrument in a clinical drug development program: examples from a heart failure program

... We report the results of qualitative studies to develop new PRO measures for use in clinical trials of omecamtiv mecarbil (a selective, small molecule activator of cardiac myosin) for pa[r] ...

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Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations

Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations

... beta cardiac myosin heavy chain (MHC) gene account for approximately half of all cases of familial hypertrophic cardiomyopathy, the molecular causes of sporadic ...

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Cardiac beta myosin heavy chain diversity in normal and chronically hypertensive baboons

Cardiac beta myosin heavy chain diversity in normal and chronically hypertensive baboons

... Ca2+-activated myosin ATPase activity in hypertrophied left ventricles was decreased by 35% (P less than ...that cardiac MHCs of primates may exist in alternative molecular forms that are indistinguishable ...

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