cardiac remodeling
Identification of target genes in cardiomyopathy with fibrosis and cardiac remodeling
... reaction (PCR) prior to the immunosuppressive therapy [8]. Hamshere at el provided a therapy by administration of granulocyte colony-stimulating factor (G-CSF) with intracoronary autologous bone marrow-derived cells ...
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Reversal of Systemic Hypertension-Associated Cardiac Remodeling in Chronic Pressure Overload Myocardium by Ciglitazone
... and cardiac fibrosis in chronic pressure overload, in part, by increasing SOD, eNOS and elastin and decreasing NOX4, MMP and collagen synthesis and degradation, chronic pressure overload analogous to systemic ...
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Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice
... attenuate cardiac fibrosis in rats infused with Ang II (13, 14), although the attenuation by hydralazine is not a common finding ...II–induced cardiac fibrosis dictates that Ang II directly activates ...
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TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways
... Figure 2A depicts representative echocardiograms for each group of mice at 12 weeks of age, whereas Figure 2, B–E, summarizes the results of group data (4 wk, n = 6/group; 12 wk, n = 9/group). Consistent with our prior ...
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Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats
... cardiomyopathy. Cardiac hypertrophy is a typical type of cardiac remodeling [2], where not only the crucial cardiac cell myocyte, but also other components like fibroblasts, collagens, ...
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Apocynin influence on oxidative stress and cardiac remodeling of spontaneously hypertensive rats with diabetes mellitus
... change cardiac struc- tures or function in control ...attenuated cardiac hypertrophy, oxidative stress, cardiac fibrosis, and diastolic ...on cardiac remodeling in adult SHR, we cannot ...
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Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction
... in cardiac development, and lately, high-throughput RNA sequencing has been extensively utilized to profile and explore the transcriptome landscape of lncRNAs in failing hearts ...modulating cardiac ...
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Haptoglobin genotype is a determinant of survival and cardiac remodeling after myocardial infarction in diabetic mice
... and cardiac remode- ...underlie cardiac remodeling which are Hp genotype dependent and to search for interventions aimed to mod- ulate this process and attenuate the rapid progression of heart ...
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Stress dependent cardiac remodeling occurs in the absence of microRNA 21 in mice
... during cardiac stress would influence cardiac ...that cardiac hypertrophy was com- parable in untreated animals and animals treated with antimiR-21 (Figure 3, A and B, and Supple- mental Figure ...on ...
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The MEF2D transcription factor mediates stress dependent cardiac remodeling in mice
... of cardiac gene ...pathological cardiac remodeling, but the requirement for MEF2 factors in the progression of heart disease in vivo has not been ...pathological cardiac remodel- ing, we ...
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TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
... (d) Cardiac overexpression of TRPC6 in Tg mice caused exaggerated pathologic cardiac remodeling under basal and stressed conditions that depended on the Trpc6 transgene ...
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Original Article Qiliqiangxin improves cardiac function and attenuates cardiac remodeling in rats with experimental myocardial infarction
... restored cardiac function and reversed cardiac remodeling in myocardial infarction (MI) induced heart failure ...B. Cardiac systolic function indicated by LVEF and LVFS, as well as left ...
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Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity
... adverse cardiac remodeling remains ...of cardiac hypertrophy and in failing human ...mediates cardiac expression of STARS, which in turn activates SRF target ...in cardiac function in ...
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Lipid damage is the best marker of oxidative injury during the cardiac remodeling process induced by tobacco smoke
... Tobacco smoke can lead to cardiovascular diseases due to its effects on the vascular system and direct ef- fects on cardiac remodeling and function [2–7]. Several studies have shown that ETS induces ...
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Smooth muscle cell sheet transplantation preserve cardiac function and minimize cardiac remodeling in a rat myocardial infarction model
... Cell sheet technology has been developed using temperature-responsive culture dishes. Using this method, cells are harvested from dishes easily by a simple tem- perature reduction [6]. Recovered cells consist of intact ...
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Macrophage activation and polarization in post-infarction cardiac remodeling
... determine cardiac remodeling and healing after myocardial infarction through secretion of proteases, growth factors, influence cardiomyocyte apoptosis and ...
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Omega-3 intake is associated with attenuated inflammatory response and cardiac remodeling after myocardial infarction
... for cardiac repair, excessive inflammation favors myocardial apoptosis and cardiac remodeling, thus leading to in- creased cardiovascular mortality ...
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Effect of Ginkgo biloba extract on experimental cardiac remodeling
... ventricular remodeling can lead to ventricular dilatation, heart function disorders, chronic heart failure, and even sudden death in patients ...(ECM) remodeling after AMI, as well as the association of ...
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The adipokine fatty-acid binding protein 4 and cardiac remodeling
... While our results on LVMI might reflect a poten- tial beneficial association with cardiac remodeling, our results on NT-proBNP reflect a potential harmful asso- ciation. This is, in contrast to our ...
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Advanced Glycation Endproducts: Activators of Cardiac Remodeling in Primary Fibroblasts From Adult Rat Hearts
... Cardiac fibrosis is not only defined as an increase in the concentration of matrix components, but also in terms of changes of collagen organization and MMP expression patterns (30,31). Because similar changes were ...
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