Cartilage destruction
Deficiency of fibroblast activation protein alpha ameliorates cartilage destruction in inflammatory destructive arthritis
... localized on invadopodia [5,6], we first investigated the ex- pression of FAP in RA. A higher expression of FAP in the rheumatoid synovium as well as an increased expression by rheumatoid arthritis synovial fibroblasts ...
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Traditional Chinese medicine formula Bi Qi capsule alleviates rheumatoid arthritis induced inflammation, synovial hyperplasia, and cartilage destruction in rats
... and cartilage destruction [12, ...The cartilage oligomeric matrix protein (COMP) is an extracellular matrix protein mainly localized to tendon, cartilage, and pericartilage tissues ...
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FcγR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune complex mediated arthritis (ICA)
... and cartilage damage during immune-complex-mediated arthritis ...subsequent cartilage damage in mice lacking functional Fc γ RI and RIII (FcR γ -chain –/– ...
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Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitrostudy
... RA-related destruction of cartilage have already been obtained from sev- eral animal models of arthritis, including destructive arthritis induced by various antigens, transgenic and mutation models and ...
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Current and emerging therapeutic strategies for preventing inflammation and aggrecanase mediated cartilage destruction in arthritis
... and cartilage deterioration and inflammation are key ...(ADAMTS) cartilage-degrading aggrecanases, provide promising additions to current arthritis treatment ...inhibit cartilage destruction ...
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Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification
... Osteoblasts and chondrocytes are derived from a common precursor pool, and although it was originally thought that they are separate lineages, more recent studies indicate plasticity and transdifferentiation between ...
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... Histology of joints of arthritic control rats showed greater score for synovial proliferation, cellular infiltration in the sub synovial region, cartilage erosion and pannus formation compared to treatment groups. ...
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promotes cell migration and has been implicated in arterial tissue-repair processes. Furthermore, high CTHRC1 expression is observed in many types of cancer and this is
... Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease, causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and ...
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Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10 Q ncf1*/* mice with collagen induced chronic arthritis
... This is the first study to evaluate the impact of endo- genous ovarian hormones, as well as exogenous estradiol and raloxifene, in the chronic arthritis model of B10.Q- ncf1 */* mice. This model may more accurately relay ...
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A Rac1 inhibitory peptide suppresses antibody production and paw swelling in the murine collagen induced arthritis model of rheumatoid arthritis
... Figure 4 Effect of Rac1 carboxy-terminal peptide treatment of mice with chronic arthritis. (a) Delta hind paw ankle joint swelling of mice that started treatment at day 29 with 4 mg of Ctrl or Rac1 peptide (three times ...
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BATF regulates collagen induced arthritis by regulating T helper cell differentiation
... hyperplasia, angiogenesis in inflamed synovium, pannus formation, bone erosion, and cartilage destruction. Immune features in RA were analyzed by examining immune cell populations and cytokine production. ...
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Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis
... influence cartilage sur- vival by exerting immunoregulatory ...to cartilage destruction in RA (1, 2, 6, 9), we investigated the survival effect of PRL on chondrocytes treated in vitro or in vivo with ...
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Original Article Effects of nicotine on a rat model of early stage osteoarthritis
... articular cartilage degeneration and inflammation in a rat model of early stage osteoarthritis (OA), using T2 ...articular cartilage from the medial femoral condylar region of the knee were evaluated by ...
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Protection against cartilage and bone destruction by systemic interleukin 4 treatment in established murine type II collagen induced arthritis
... of cartilage destruction found after IL-4 treatment may well be due to a lower produc- tion of MMPs and/or inhibition of their ...late destruction is linked to stromelysin. Control of bone ...
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Rheumatoid Arthritis: Hyaluronic Acid and Cartilage Oligomeric Matrix Protein as Predictors of the Disease Progression
... specific cartilage and bone biomarkers reflecting tissue turnover, particularly hyaluronic acid and cartilage oligomeric matrix protein, to investigate disease ...acid, cartilage oligomeric matrix ...
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Mitochondrial respiratory chain dysfunction modulates metalloproteases 1, 3 and 13 in human normal chondrocytes in culture
... like cartilage, bone and synovial tissue is one of the most common events in the rheumatic pathologies ...tissue destruction, the family of metal- loproteases (MMPs) plays an important ...the ...
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HIF 2α induced chemokines stimulate motility of fibroblast like synoviocytes and chondrocytes into the cartilage pannus interface in experimental rheumatoid arthritis mouse models
... to cartilage and bone was visualized via hematoxylin/safranin-O staining, and pannus formation scored (grades 0–4) as described pre- viously ...[7]. Cartilage destruction was visualized and scored ...
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High-frequency near-infrared diode laser irradiation attenuates IL- 1β -induced expression of inflammatory cytokines and matrix metalloproteinases in human primary chondrocytes
... causing cartilage proteolysis ...degrades cartilage proteoglycans; collagen types III, IV, V, VII, and IX; laminin; and ...joint destruction in rheumatoid ...articular cartilage and ...
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Intra articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen induced arthritis
... Early cartilage destruction in AIA is characterised by loss of aggrecan and the ADAMTS family members are thought to be involved in mediating this loss ...prevents cartilage damage in a mouse model ...
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MMP-2 (-29%), MMP-3 (-15%), MMP-9 (-29%), and MMP-13
... MMPs are the main mediators of cartilage destruction. They can degrade all components of the extracellular matrix. Damaged chondro- cytes in OA produce pro-inflammatory cytokin- es, such as IL-1β and TNF-α, ...
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