Cartilage oligomeric matrix protein
Serum Cartilage Oligomeric Matrix Protein (COMP) a Biomarker of Rheumatoid Arthritis, Disease Activity and Knee Cartilage Thickness
... Serum cartilage oligomeric matrix protein (COMP) is a non-collagen glycoprotein produced by the cartilage, synovium, tendon, and ...articular cartilage damage based on ...
11
The early diagnostic value of serum neopterin and cartilage oligomeric matrix protein for osteoarticular changes among brucellosis patients at an early period
... Cartilage oligomeric matrix protein (COMP), a non- collagen biomarker for cartilage degradation, is a 524 kD glycoprotein found in articular cartilage, ligament, menis- cus, ...
5
Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis
... Cartilage oligomeric matrix protein (COMP), a 524-kd pentameric glycoprotein related to the thrombospondin family, is one of the cartilage markers ...in cartilage, and recent ...
8
Meta analysis of serum C reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis
... [8–10]. Cartilage oligomeric matrix protein (COMP) is a 535-kDa non-collagen protein which has strong relation with the incidence of ...
6
Rheumatoid Arthritis: Hyaluronic Acid and Cartilage Oligomeric Matrix Protein as Predictors of the Disease Progression
... of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease ...serum cartilage oligomeric matrix protein determines the ...
9
Cartilage oligomeric matrix protein induced complement activation in systemic sclerosis
... extracellular matrix components, such as collagen type I, III [2] and V [3] in the affected ...of cartilage oligomeric matrix protein (COMP) in both lesional and non-lesional skin ...
8
High Level of Serum Cartilage Oligomeric Matrix Protein and Plasma Interleukin-6 Increase the Risk of Ultrasound-detected Synovial Inflammation in Knee Osteoarthritis
... survival protein, such as baculoviral IAP repeat-containing protein-4 (BIRC4) and x-linked inhibitor of apop- tosis protein ...(XIAP). Cartilage oligomeric matrix protein ...
8
Analysis of Electropherogram Profile of Crude Cartilage Oligomeric Matrix Protein for Rheumatoid Arthritis Diagnosis
... Cartilage oligomeric matrix protein (COMP) is a potential biomarker to monitor the development of cartilage damage and injury in rheumatoid arthritis ...
5
Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen induced arthritis
... chromatography. Protein content was determined by measuring absorbance at 280 nm, using a calculated extinction coefficient of 71,390/M per ...against cartilage oligomeric matrix ...
8
Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept
... (cartilage oligomeric matrix protein, also called thrombospondin-5), originally iso- lated and characterized in cartilage ...primarily cartilage-derived marker during ...
5
Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis
... morphogenetic protein-2 in vitro ...the matrix breakdown and thereby increasing the mechanical load of the diseased tissue, this mechanical load could counteract the LRF/FBI-1 effect and upregulate only the ...
10
Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein)
... Proteomic analyses were also performed on tissue extracts from macroscopically normal, sub-acute (3-6 weeks post injury) and chronic injured (>3 months post injury) SDFTs to investigate the effect of injury on ...
25
Original Article The relationship between the serum and synovial fluid osteopontin (OPN), cartilage oligomeric matrix protein (COMP), and the severity of knee osteoarthritis (KOA) assessed by radiology
... the disease has developed to a very serious stage when obvious lesions are observed under X-rays. But this indicates that the value of X- rays in the early diagnosis of patients is not high [4, 5]. Therefore, one study ...
8
Serum levels of Cartilage Oligomeric Matrix Protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis
... tissue matrix processes in OA is by monitoring tissue proteins or their fragments released into serum ...is cartilage oli- gomeric matrix protein ...non-collagenous protein primarily ...
8
Cartilage oligomeric matrix protein specific antibodies are pathogenic
... (TSP) protein family, which includes TSP-1, TSP-2, TSP- 3, TSP-4 and ...in cartilage and synovium, as evidenced by the binding of biotinylated mAbs in ...
14
Serum cathepsin K levels of patients with longstanding rheumatoid arthritis: correlation with radiological destruction
... Skoumal M, Kolarz G, Klingler A: Serum levels of cartilage oligomeric matrix protein COMP: a predicting factor and a valuable parameter for disease management in rheumatoid arthritis.. S[r] ...
6
Developments in the scientific understanding of osteoarthritis
... cellular matrix of the articular cartilage have been associated with early-onset OA ...in cartilage, including those encoding types IV, V, and VI collagens, as well as cartilage ...
9
A putative Chondroprotective role for IL 1β and MPO in herbal treatment of experimental osteoarthritis
... of cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), malondialdehyde (MDA), myeloperoxidase (MPO), Interleukin-1 beta (IL-1 β ) and superoxide dismutase activity (SOD) were ...
9
Novel COL9A3 mutation in a family diagnosed with multiple epiphyseal dysplasia: a case report
... encoding cartilage oligomeric matrix protein (COMP), matrilin-3 (MATN3), and the alpha 1–3 chains of type IX collagen (COL9A1, COL9A2, COL9A3) result in autosomal dominant MED [1], and a ...
6
A Chinese Family with Pseudoachondroplasia Caused by COMP Gene Mutation
... in cartilage oligomeric matrix protein (COMP) while MED may be caused by mutations in the genes encoding COMP, type IX colla- gen (COL9A1, COL9A2, and COL9A3), matrilin-3 (MATN3), and solute ...
8