Cartilage Oligomeric Matrix Protein (COMP) release assay.75
Cartilage oligomeric matrix protein specific antibodies are pathogenic
... Generation and characterization of anti-COMP mAbs To obtain a broad set of COMP-specific mAbs, we gener- ated a panel of mAbs using COMP-deficient mice and COMP-wild type mice with Ncf1 mutation immunized with the native ...
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Cartilage oligomeric matrix protein induced complement activation in systemic sclerosis
... 27. Happonen KE, Saxne T, Geborek P, Andersson M, Bengtsson AA, Hesselstrand R, Heinegård D, Blom AM: Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-alpha treatment. Arthritis Res Ther 2012, ...
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Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis
... Conclusion In summary, our results demonstrate that COMP is present in the earliest stages of human bone and joint development. COMP is also a component of the adult healthy articular carti- lage matrix and is ...
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Serum Cartilage Oligomeric Matrix Protein (COMP) a Biomarker of Rheumatoid Arthritis, Disease Activity and Knee Cartilage Thickness
... Serum cartilage oligomeric matrix protein (COMP) is a non-collagen glycoprotein produced by the cartilage, synovium, tendon, and ...articular cartilage damage based on ...
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Analysis of Electropherogram Profile of Crude Cartilage Oligomeric Matrix Protein for Rheumatoid Arthritis Diagnosis
... Cartilage oligomeric matrix protein (COMP) is a potential biomarker to monitor the development of cartilage damage and injury in rheumatoid arthritis ...immunosorbent assay, but ...
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Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis
... Correlation between serum COMP levels and knee OA Pooled results of nine studies revealed a significant ele- vation of serum COMP in OA patients compared with healthy controls (SMD 0.81,[r] ...
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Rheumatoid Arthritis: Hyaluronic Acid and Cartilage Oligomeric Matrix Protein as Predictors of the Disease Progression
... and cartilage and is thought to contribute to the lubricating mechanisms of synovial ...specific cartilage and bone molecules reflecting tissue turnover, as HA and COMP to investigate disease ...
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Meta analysis of serum C reactive protein and cartilage oligomeric matrix protein levels as biomarkers for clinical knee osteoarthritis
... [8–10]. Cartilage oligomeric matrix protein (COMP) is a 535-kDa non-collagen protein which has strong relation with the incidence of ...
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Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen induced arthritis
... COMP-deficient mice developed the same high levels of anti- CII antibodies as wild-type mice during CIA. We have previ- ously reported that collagen IX-deficient mice are more sus- ceptible to CAIA, most likely due to ...
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Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept
... A drawback of this study is the lack of radiographs for comparison with the changes in serum COMP levels. When we started to include patients in the protocol, we did not include radiographic follow-up, because we did not ...
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Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein)
... the protein profile to return to normal suggests that injury permanently changes the composition of tendon ECM, which may compromise both the mechanical properties of the tissue and its influence on the responses ...
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Serum levels of Cartilage Oligomeric Matrix Protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis
... Conclusion The changes in serum levels of COMP, are small and do not compromise the utility of COMP as a biomarker, e.g. for monitoring treatment effects on the tissue. Thus, we suggest that samples of blood for analysis ...
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The early diagnostic value of serum neopterin and cartilage oligomeric matrix protein for osteoarticular changes among brucellosis patients at an early period
... and cartilage among the people diagnosed as bru- ...of cartilage by determining the serum COMP level, which provides a new method for early diagnosis of osteoarticular changes in this disease, in- dicating ...
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High Level of Serum Cartilage Oligomeric Matrix Protein and Plasma Interleukin-6 Increase the Risk of Ultrasound-detected Synovial Inflammation in Knee Osteoarthritis
... Body mass index also gave significant contri- bution in increasing the risk of synovial inflam- mation in knee OA 1.15-1.16 times higher than control (OR = 1.16 as a covariate of high level of serum COMP, p = 0.029; and ...
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Original Article The relationship between the serum and synovial fluid osteopontin (OPN), cartilage oligomeric matrix protein (COMP), and the severity of knee osteoarthritis (KOA) assessed by radiology
... articular cartilage injury ...non-collagen protein are the main macromo- lecular constitutive substances in human ar- ticular ...cell matrix. It is also the main component of the non-collagen ...
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Protein and transcriptome signatures of cartilage ageing and disease
... predominant protein in the samples. This may be due to uptake by the cartilage of serum albumin and release into the matrix during the experiment but also highlight the need for proficient ...
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Glycoprotein-Dependent Acidification of Vesicular Stomatitis Virus Enhances Release of Matrix Protein
... Fluorometric assay. To measure the fluorescence intensity of rVSV-MLG virions in vitro, we added 1 g of virus to HMN buffer (10 mM HEPES, 10 mM morpholineethanesulfonic acid, 150 mM NaCl, pH 7) in a cuvette with ...
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Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis
... OA cartilage in culture, and this effect was due to restora- tion of the lost LRP-1 function by blocking the LRP-1 sheddase activities of ADAM-17 and MMP-14 (Figure ...OA cartilage may be an effective way ...
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Curcumin reduces prostaglandin E2, matrix metalloproteinase 3 and proteoglycan release in the secretome of interleukin 1β treated articular cartilage
... reference protein in the western blots, as there are no proteins that can effectively be used as reference proteins in the ...a protein assay to ensure that equal quantities of protein were ...
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Tyrosine kinase-dependent release of an adenovirus preterminal protein complex from the nuclear matrix.
... pTP-NM protein complex is capable of binding Ad origin ...shift-supershift assay, originally devel- oped to study the interactions of pTP and Ad polymerase (56), is shown in ...no protein, HeLa ...
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