Cartilage Regeneration
Dual functional construct containing kartogenin releasing microtissues and curcumin for cartilage regeneration
... efficient cartilage regeneration in the joint in a skeletally mature rabbit model 12 weeks after implant- ...of cartilage or other similar tissue ...
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Should we use cells, biomaterials, or tissue engineering for cartilage regeneration?
... time, cartilage has been a major focus of the whole field of tissue engineering, both because of the constantly growing need for more effective options for joint repair and the expectation that this apparently ...
9
Chondrogenic Differentiation Capacity of Human Umbilical Cord Mesenchymal Stem Cells with Platelet Rich Fibrin Scaffold in Cartilage Regeneration (In Vitro Study)
... various reconstruction techniques applied in ortho- pedics and oral and oral maxillofacial surgery such as subchondral drilling, abrasion, micro fracture, mosaic plasty with osteochondral graft, and autol- ogous ...
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A novel construct with biomechanical flexibility for articular cartilage regeneration
... induce cartilage regener- ation both in vitro and in vivo, but they are still far from obtaining regenerated cartilage that has properties simi- lar to those of native cartilage, as well as ...
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Mathematical Modeling of Cartilage Regeneration in Cell-Seeded Scaffolds.
... modeling cartilage regeneration in cell-seeded scaffold materials were ...tissue regeneration in the local environment of a single chondrocyte seeded in a nutrient-rich hydrogel scaffold ...
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Development of a salmon derived crosslinked atelocollagen sponge disc containing osteogenic protein 1 for articular cartilage regeneration: in vivo evaluations with rabbits
... comparison with the no treatment control. We can speculate possible reasons to explain this phenomenon. First, in the patellofemoral joint, immediate motion and loading results in high shear forces, preventing the for- ...
10
Increased recruitment of endogenous stem cells and chondrogenic differentiation by a composite scaffold containing bone marrow homing peptide for cartilage regeneration
... for cartilage regeneration by stem cells homing have focused on the application of chemokines and growth factors, such as transforming growth factor-β3 and -β1 [50, 51], stromal cell-derived factor-1 [52, ...
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Arthroscopic cartilage regeneration facilitating procedure for osteoarthritic knee
... hyaline cartilage was classically considered having no or low potential for regeneration [41-46], some still thought that it does have the capacity to grow and remodel extensively during pre- and post- ...
11
Over-production of therapeutic growth factors for articular cartilage regeneration by protein production platforms and protein packaging cell lines
... formulation. As mentioned earlier, GP2-293 is a HEK 293-based retroviral packaging cell line used for large-scale protein production and packaging. It is a cellular platform for over-production of therapeutically ...
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Fibrin hydrogels functionalized with cartilage extracellular matrix and incorporating freshly isolated stromal cells as an injectable for cartilage regeneration
... Articular cartilage is an avascular tissue with a complex structure that has a limited capacity for self repair ...articular cartilage still is a challenge in the field of tissue engineering [1, ...to ...
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Mathematical and Computational Mixture Models for Cartilage Regeneration in Cell-Seeded Scaffolds.
... for cartilage tissue engineering has seen only limited development and is ripe for further ...to cartilage tissue engineering, this model accounted for cell division, and osmotic effects arising due to ...
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Enrichment of CD146+ Adipose-Derived Stem Cells in Combination with Articular Cartilage Extracellular Matrix Scaffold Promotes Cartilage Regeneration
... Articular cartilage, lacking blood vessels, lymphatic vessels, and nerves, is not subjected to systemic regulation ...[1]. Cartilage is susceptible to damage, and acute lesions without proper treatment may ...
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Control of articular synovitis for bone and cartilage regeneration in rheumatoid arthritis
... articular cartilage loss showed cartilage regeneration and relief of symptoms ...the regeneration potential of the joint should be paid with full attention even in RA patients in the current ...
11
Kartogenin hydrolysis product 4-aminobiphenyl distributes to cartilage and mediates cartilage regeneration
... tobacco smoke [56]. However, it is further proved that 4-ABP toxicity is induced by its metabolic activation to form a reactive electrophile by N-hydroxylation and N-esterification reaction; this electrophile covalently ...
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Tracking mesenchymal stem cell contributions to regeneration in an immunocompetent cartilage regeneration model
... most likely due to fluid flow–induced shearing forces caused by joint movement, which may remove cells not firmly attached to the cartilage matrix. The latter finding underscores that more efficient site-specific ...
13
Effects of osteochondral defect size on cartilage regeneration using a double network hydrogel
... created with a 2-mm deep vacant space above implanted DN gel was feasible in defect sizes between 2.5 and 5.8 mm diameter in the rabbit model here. The 2.5-mm and 4.3- mm DN gel implanted defects maintained relatively ...
9
Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration
... Introduction: Transplantation of mesenchymal stem cells (MSCs) derived from synovium is a promising therapy for cartilage regeneration. For clinical application, improvement of handling operation, ...
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Use of Mesenchymal Adult Stem Cell for Cartilage Regeneration by Hydrogel
... obtained from bone marrow [6]. It is understood that there is a need for three dimensional culture conditions in order to guide the differentiation of ADSCs into cartilage [7]. Therefore, these cells are cultured ...
12
Instruments for reproducible setting of defects in cartilage and harvesting of osteochondral plugs for standardisation of preclinical tests for articular cartilage regeneration
... experiment after a healing time of up to 1 year or even less. In preliminary tests, we experienced that the preparation with hammer and chisel or punches could result in speci- men with uneven geometry regarding the ...
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Stem cells in articular cartilage regeneration
... articular cartilage, in particular as far as high-level studies are concerned: in fact, most of the available papers are case series, while only few papers re- ported ...
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