caspase-11
Protective role for caspase 11 during acute experimental murine colitis
... of caspase-11, rather than its acti- vation, that is dependent on TRIF and type I IFN signaling (5, ...of caspase-11 in the colitis ...in caspase-11 upregulation in colons from ...
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Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture
... lacking caspase-1 (12). These caspase-1-deficient mice also lack caspase-11 and are referred to here as Caspase-1/11 ⫺/⫺ mice ...(25). Caspase-1 is the critical effector ...
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TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis
... for caspase-11- dependent immune responses in endotoxemia, wild-type (WT), TRIF KO and Caspase-11 KO mice were ...of Caspase-11 blocked the release of IL-1α and IL-1β in ...
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Caspase 11 regulates the tumour suppressor function of STAT1 in a murine model of colitis associated carcinogenesis
... To determine whether the increased intestinal in fl ammation in Casp11 − / − mice led to increased colitis-associated col- orectal tumourigenesis, Casp11 − / − mice and their wild-type (WT) littermates were treated with ...
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Caspase 11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod Induced Psoriasis
... both caspase-1 and -11 (casp1/11) (Aira et ...of caspase-1 during psoriasis (Cho et ...of caspase-11 during IMQ-induced skin ...
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Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis
... of caspase-11 through TLR or other ...mature caspase-11 by signal transduction of a cell surface receptor? Recent studies have discovered that the host is capable of TLR4-independent ...
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Caspase 11–mediated endothelial pyroptosis underlies endotoxemia induced lung injury
... of caspase-4 and caspase-5 in human ECs and caspase-11 in mouse ECs, thereby augmenting the subsequent pyroptotic response induced by intracellular LPS binding to these inflam- matory ...
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Caspases determine the vulnerability of oligodendrocytes in the ischemic brain
... broad-spectrum caspase inhibitor, in ...of caspase-11 and substantial activation of caspase-3, which led to cell ...of caspase-11 suppressed the caspase-3 activation and ...
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Investigating Inflammasome Activation in Response to Legionella Pneumophila and its Application to Other Bacterial Pathogens
... to caspase-11 activation (Meunier et ...activating caspase-11 independently of vacuolar disruption as well (Pilla et ...enhance caspase-11 activation requires further ...
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Ablation of caspase-1 protects against TBI-induced pyroptosis in vitro and in vivo
... triggered. Caspase is a protease involved in cell apoptosis, with more than ten ...subtypes. Caspase-1 regulates cell apoptosis by shearing Bcl-XL and the inflammatory response of related cytokines which ...
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PubMedCentral-PMC5663346.pdf
... ortholog caspase-11 in mice activated macrophage pyroptosis, a form of programmed cell death resulting in rapid cell lysis ...(10–13). Caspase-11 cleavage of gasdermin D (Gsdmd) induces ...
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Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
... of caspase cascade as an exec- utors of apoptosis, the possible involvement of caspase 3 and caspase 8 in sodium butyrate-induced apoptosis in breast cancer and normal cells were ...of caspase ...
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Original Article Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production
... Abstract: Apoptosis of osteoblasts caused by glucocorticoids has been identified as an important contributor to the development of osteoporosis. Tanshinone IIA (Tan), an active ingredient extracted from the rhizome of ...
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Ropivacaine promotes apoptosis of hepatocellular carcinoma cells through damaging mitochondria and activating caspase-3 activity
... Ropivacaine is widely used for interventional spinal procedures and is generally accepted as safe. Recently, several studies have focused on the potential cytotoxic effects of ropivacaine on HCC cells [14, 15]. The ...
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Original Article MiR-423-5p inhibits human cardiomyoblast proliferation and induces cell apoptosis by targeting Gab 1
... We recruited 12 DCM patients (47 ± 12 years, 33% males) with New York Heart Association (NYHA) function classes IeIV (1/Class I, 5/Class II, 4/Class III, 2/Class IV), and a control group of 12 healthy volunteers (47 ± ...
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R-roscovitine Reduces Lung Inflammation Induced by Lipoteichoic Acid and Streptococcus pneumoniae
... cleaved caspase-3 compared with vehicle after 6 h (Figures 1C, D; P < ...the caspase inhibitor zVAD-fmk reversed the amount of cleaved caspase-3 to near vehicle levels (P < ...induced ...
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Conditional deletion of caspase 8 in macrophages alters macrophage activation in a RIPK dependent manner
... that caspase-8–deficient macrophages are prone to a caspase-independent death in response to DR ligation; yet, caspase-8–deficient myeloid populations are not predisposed to unchecked survival, as ...
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CASPASE DEPENDENT APOPTOSIS INDUCED BY CLADRIBINE IN THE ESTROGEN RECEPTOR NEGATIVE BREAST CANCER CELL LINE, MDA-MB468
... particular, caspase- mediated cleavages destabilize structural components of the cytoskeleton, inactivate key components of DNA repair pathways, and interrupt signal transduction pathways involved in cell survival ...
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Activation of Caspase-2 in Apoptosis
... of Caspase-2 Occurs Later than the Activation of Caspase-3-like Proteases when Cells Undergo Apoptosis—To determine possible interactions between caspase-2 and other family members, we compared the ...
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Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells
... Nuclear Factor kappa-B (NF-κB) is a transcription fac- tor implicated in inflammation. NF-κB is formed by members of Rel/NF-κB family such as p50, p52, p65 (RelA), RelB or c-Rel in homo or heterodimeric com- plexes. The ...
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