Caspase-3 activation
Excitotoxin-induced caspase-3 activation and microtubule disintegration in axons is inhibited by taxol
... their activation. Both precaspase-3 and biochemically ac- tive caspase-3 have been shown to be present in healthy axons of cultured neurons [38] although the epitope of active ...
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Caspases determine the vulnerability of oligodendrocytes in the ischemic brain
... otal role in the execution of ischemia-induced OLG death. Permanent focal cerebral ischemia produced by MCAO, a commonly used ischemia model, resulted in a time-dependent loss of OLGs in infarct areas. This finding is ...
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Non apoptotic function of Drosophila caspase activation in epithelial thorax closure and wound healing
... sub-lethal caspase 3 activation in Drosophila pupal epithelia during thorax ...of caspase activation, using the pan-caspase inhibitor p35, enhanced the speed of pupal thorax ...
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Caspase 3-Dependent Cell Death of Neurons Contributes to the Pathogenesis of West Nile Virus Encephalitis
... induces caspase 3 acti- vation. To directly examine the role of caspase 3 activation in WNV-mediated neuronal injury, we isolated primary cortical neurons from wild-type C57BL/6 ...day ...
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Co-involvement of the mitochondria and endoplasmic reticulum in cell death induced by the novel ertargeted protein HAP
... 1. Caspase-3 activation occurred in the process of HAP-induced ...the caspase-3 specific synthetic fluorogenic ...the activation of ...native caspase-3 substrate ...
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Activation of Caspase-2 in Apoptosis
... of Caspase-2 Occurs Later than the Activation of Caspase-3-like Proteases when Cells Undergo Apoptosis—To determine possible interactions between caspase-2 and other family members, we ...
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Involvement of caspase 8, 9 and 3 in p phenylenediamine induced apoptosis in murine myeloma p3 cells: regulation by reactive oxygen species
... of caspase-8, -3 and -9 was assessed by spectrophotometry using colorimetric ...Furthermore, caspase-8, -9 and -3 activities in PPD treated cells were higher than those of untreated ...by ...
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Caspase 3 mediated cleavage of p65/RelA results in a carboxy terminal fragment that inhibits IκBα and enhances HIV 1 replication in human T lymphocytes
... after activation in apoptotic cells ...of caspase-3 after treatment with PMA or PHA, these cells were viable and caspase-3 activation did not affect T cell ...vates ...
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Mechanisms of ATF4-mediated neuronal apoptosis
... reduced caspase-3 activation and tissue loss in response to TBI and hypoxic-ischemic brain injury, relative to wild type (Gibson et ...of caspase activity has proven effective, a notion that ...
163
Involvement of Reactive Oxygen Species in Sonodynamically Induced Apoptosis Using a Novel Porphyrin Derivative
... and caspase-3 ...cells, caspase-3 activation, and nitroxide generation suggests that ultrasonically generated sin- glet oxygen is an important mediator of sonodynam- ically induced ...
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Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells
... Artemisinin is an effective novel anti-malarial drug with low toxicity. No toxicity has been reported with oral administration [31]. Although it has been reported that artemisinin inhibits cell proliferation in many ...
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Pleiocarpa pycnantha leaves and its triterpenes induce apoptotic cell death in Caco 2 cells in vitro
... which culminated in caspase-3 activation. Triterpenoids such as ursolic acid, corosolic acid and maslinic acid have been reported to induce apoptosis by a similar mechanism [28, 29, 34]. However, ...
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IQGAP1 Is Important for Activation of Caspase 1 in Macrophages and Is Targeted by Yersinia pestis Type III Effector YopM
... inflammasome activation in Yersinia-infected macrophages and mechanisms of caspase-1 inhibition by ...injectisome activation and translocon insertion into the plasma ...to activation of NLRP3 ...
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Scoping review of biological treatment of deficiency of interleukin-36 receptor antagonist (DITRA) in children and adolescents
... Results: Our literature research revealed 12 pediatric patients with DITRA who have received treatment with biologicals and we add a further not yet reported patient. Out of these 13 patients 10 were homozygous including ...
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Dipyrithione induces cell-cycle arrest and apoptosis in four cancer cell lines in vitro and inhibits tumor growth in a mouse model
... Cells were seeded into 96-well plates at 5 × 10 3 cells per well 24 h before treatment. After treatment with different drugs, cell proliferation was determined using MTT (3-(4,5 ...
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Autophagy contributes to apoptosis in A20 and EL4 lymphoma cells treated with fluvastatin
... Previous study has demonstrated the present of autophagy in apoptotic cells [17,18]. In the present study, to further explore whether autophagy occurs during apoptotic process of lymphoma cells treated by fluvastatin, ...
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Rudy, Anita (2007): Unusual apoptotic signaling pathways in cancer cells induced by cephalostatin. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Inhibitor of apoptosis proteins (IAPs) are shown to be expressed to a higher extent in cancer than in normal tissue and are connected to chemoresistance. Smac/DIABLO binds to various IAPs thus neutralizing their ...
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INDUCTION OF APOPTOSIS BY CASPASES IN THE LEAVES OF SANSEVIERIA ROXBURGHIANA SCHULT AND SCHULT F
... by activation of extrinsic and intrinsic pathways, which results from activation of ...of caspase-3, caspase-8, and caspase-9 were studied in HepG2 cancer cell line using ...
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CASPASE DEPENDENT APOPTOSIS INDUCED BY CLADRIBINE IN THE ESTROGEN RECEPTOR NEGATIVE BREAST CANCER CELL LINE, MDA-MB468
... intracellular activation of this adenosine analog in MDA-MB468 breast cancer cells, may be responsible for the differential effect exerted by ...[25]. Activation of extracellular adenosine receptors did not ...
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Activation of caspase 3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions
... for caspase-mediated cleavage of ...and activation of caspase-3, we examined whether the amount of the proapoptotic Bax protein in the conformational state that results in activation of ...
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