Caspase-9
The correlation between caspase-9 and caspase-3 on sepsis case: an experimental study on the Balb/C Mice induced by lipopolysaccharide
... activating caspase 9 (cas-9). These two pathways will produce caspase cascades which in turns results in ...the caspase 3 (cas-3) causing the apoptotic apparatus taking part in DNA ...
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The Expression and Prognosis of Caspase-9 in Hepatocellular Carcinoma
... Immunohistochemical assessment was performed by two investigators respectively without any knowledge of the clinicopathological details of the patients. For each slide, we chose five fields at X400 magnification ...
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Biomolecular Aspect of Apoptosis Pathway: Caspase 8 and Caspase 9 on Polifenol Exposure of Phaleria macrocarpa (Scheff ) Boerl on Mice Balb/c
... Statistical Analysis: Caspase-8 and caspase-9 data are ratio scales. The data were analyzed descriptive analysis in the form of mean, median, mode and standard deviation, then assessed to have normal ...
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Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection
... of caspase-9 activity in memory loss pathogenesis, we specifically inhibited ...of caspase-8 ...active caspase-9, caspase-3, and cas- ...active caspase-9, and the ...
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The expression of caspase 3, caspase 7, caspase 9 and cytokeratin AE1/AE3 in goats with enzootic nasal adenocarcinoma: an immunohistochemical study
... addition, caspase-3 activity indicative of apoptosis has been reported in tumour cells of enzootic na- sal adenocarcinoma (Ozmen et ...However, caspase expression is not fully characterised in animal ...
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Investigation of the Effects of Zebularine on Caspase 3 and Caspase 9 Involved in Anticancer and Apoptotic Mechanisms in SKBR3 Breast Cancer Cell Line
... DOI: 10.4236/jct.2019.103019 240 Journal of Cancer Therapy groups including initiators, effectors and inflammatory caspases. Caspases are present in the cell as zymogen in inactive form. The initiator caspases cause di- ...
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The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells
... that caspase-9 is the initiator caspase responsible for the mitochondrial apoptosis, we analyzed several other features of this pathway in order to define the mechanism of hydralazine-induced ...
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Endothelial and myocyte apoptosis in the heart exposed to ischaemia/reperfusion injury
... of Caspase-9 Inhibition by lAPs - Caspase-9 inhibition by the BIR3 domain of XIAP requires the initial processing of the pro enzyme to expose the lAP binding motif at the N terminus of the ...
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Mediation of exogenous hydrogen sulfide in recovery of ischemic post-conditioning-induced cardioprotection via down-regulating oxidative stress and up-regulating PI3K/Akt/GSK-3β pathway in isolated aging rat hearts
... (reverse). Caspase- 3 primers were 5′-CAGACAGTGGAACTGACGATGA-3′ (forward) and 5′-AACAGAAACATGCCCCTACCCC-3′ ...(reverse). Caspase-9 primers were 5′-CCCGTGAAGCA AGGATTT-3′ (forward) and ...
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Rudy, Anita (2007): Unusual apoptotic signaling pathways in cancer cells induced by cephalostatin. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Inhibitor of apoptosis proteins (IAPs) are shown to be expressed to a higher extent in cancer than in normal tissue and are connected to chemoresistance. Smac/DIABLO binds to various IAPs thus neutralizing their ...
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<p>Gross saponin of <em>Tribulus terrestris</em> improves erectile dysfunction in type 2 diabetic rats by repairing the endothelial function of the penile corpus cavernosum</p>
... Methods: The T2DMED model was constructed by high-fat and high-sugar feeding and streptozotocin injection. After 4 weeks of GSTT intervention. Intracavernous pressure (ICP) and mean arterial pressure (MAP) were measured ...
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Müller, Irina (2004): Characterisation of apoptosis signal transduction induced by the marine compound cephalostatin 1 in leukemic cells. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... in caspase-9 ...Thus, caspase-9 is activated by a cytochrome c-independent ...precedes caspase-9 activation and is not abrogated by the pan- caspase inhibitor ...
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Effect of novel nanocomposite (NSACC) against Benzo[a]pyrene induced lung cancer in mice on p53, caspase 3, 9 genes and histopathological examination
... of caspase 3 and concomitant PARP cleavage, which is the hallmark of caspase-dependent apoptosis ...not caspase-9, supporting the rationale that apoptosis occur via a membrane-mediated ...a ...
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Efficacy of hesperidin (HDN), on apoptotic markers in tissue of normal and myocardial ischemic rats
... The present study shows that the antiapoptotic effect of hesperidin might be by downregulated expressions of TNF- α, Fas, caspase-3, caspase-9, Bax and upregulated expressions of Bcl-2, Bcl-xL in ...
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Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction
... Materials and methods: In this study, AMI model was established by ligating the anterior descending coronary artery in Wistar rats. After 4 weeks gavage of PF, the apparent signs and the left ventricle weight index of ...
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Maternally preset program of apoptosis and caspases involved in execution of the apoptosis at midblastula transition (MBT) but not before in Xenopus laevis embryogenesis
... SAMDC, caspase-8, p53, beta-galactosidase, caspase-9, and alpha-globin into Xenopus fertilized eggs and examined the development of the injected ...and caspase-9, cell dissociation took ...
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Original Article Hydroxycamptothecin-induced apoptotic gene expression profiling by PCR array in human Tenon’s capsule fibroblasts
... were promoted by 2.63, 2.23, 7.43, 2.05 and 7.86 fold, respectably. We speculate that HCPT may firstly activate P53 and Bax, and then release cytochrome c to initiate caspase-9, leading to a caspase ...
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The potential functions of FAM46C in oral squamous cell carcinoma
... Notes: HSC4 cells transduced with FAM46C shRNAs (siFAM46C) lentivirus or control shRNA (siNC) lentivirus and at same time treated with U0126 or vehicle (DMSO). (A) Cell apoptosis was evaluated by flow cytometry after 48 ...
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Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani
... pan- caspase inhibitor (Z-VAD-FMK), caspase-3 inhibitor (Z- DEVD-FMK), caspase-2 inhibitor (Z-VDVAD-FMK), caspase-9 inhibitor (Z-LEHD-FMK) or caspase-10 in- hibitor (Z-AEVD-FMK) ...
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<p>LncRNA MALAT1 Promotes the Proliferation, Migration, and Invasion of Melanoma Cells by Downregulating miR-23a</p>
... up-regulated Caspase 3 and Caspase 9, but also resulted in cell proliferation and S-phase cell decrease, G1-phase cell increase, and cell migration and invasion ability ...
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