Caspase-dependent apoptosis
Clausenidin induces caspase dependent apoptosis in colon cancer
... of caspase 9 in MCF-7 cells ...of caspase 9 increases in clausenidin-treated hepG2 cells (Unpublished ...induces apoptosis has not been fully ...on caspase-dependent apoptosis ...
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Functional disruption of macrophage migration inhibitory factor (MIF) suppresses proliferation of human H460 lung cancer cells by caspase-dependent apoptosis
... The ability of MIF to suppress anti-inflammatory path- ways is highly relevant to the growing appreciation of chronic inflammatory pathways promoting tumor growth and metastatic development. In host immune defense, in- ...
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Induction of caspase dependent apoptosis by α-Mangostin in breast cancer cells
... and apoptosis induction in highly invasive and metastatic human breast cancer MDA-MB-231 cell line was determined by performing cell proliferation and apoptosis ...
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Caspase-Dependent Apoptosis of Retinal Ganglion Cells During the Development of Diabetic Retinopathy
... the apoptosis of the neuronal structures of the ...to caspase- -dependent intracellular ...the caspase- -dependent mechanism of apoptosis of retinal ganglion cells in the early ...
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Activation of caspase-dependent apoptosis by intracellular delivery of cytochrome c-based nanoparticles
... protein payload from degradation and in addition enab- ling targeted and controlled delivery is of considerable interest. Herein, we presented a new method for the delivery of Cyt c, an apoptotic protein, to model cancer ...
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The New World arenavirus Tacaribe virus induces caspase dependent apoptosis in infected cells
... Induction of apoptosis in Vero cells by Newcastle disease virus requires viral replication, de-novo protein synthesis and caspase activation.. Caspase cleavage of viral proteins, another[r] ...
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Induction of Caspase-Dependent Apoptosis in Cultured Cells by the Avian Coronavirus Infectious Bronchitis Virus
... elicits apoptosis in IBV-infected ...induce apoptosis by interacting or interfering with the classical apoptotic ...of apoptosis in IBV- infected ...undergo apoptosis in response to this ...
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Inhibition of neddylation regulates dendritic cell functions via Deptor accumulation driven mTOR inactivation
... Neddylation, a newly identified post-translational modification, is significant for the activity and stability of target proteins. The exact role of neddylation in the pathogenesis of inflammatory bowel disease, ...
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Nickel chloride-induced apoptosis via mitochondria- and Fas- mediated caspase-dependent pathways in broiler chickens
... apaf-1, caspase-9, caspase-3, caspase-6, caspase-7 and PARP expression and decreased XIAP ...mitochondria-mediated caspase-dependent ...cyt-c, caspase-9, caspase-3 ...
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Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma
... PI103-induced apoptosis. GANT61 and PI103 also synergize to induce apoptosis in cultured primary RMS cells emphasizing the clinical relevance of this ...trigger caspase-dependent ...
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Effect of novel nanocomposite (NSACC) against Benzo[a]pyrene induced lung cancer in mice on p53, caspase 3, 9 genes and histopathological examination
... of caspase 3 and concomitant PARP cleavage, which is the hallmark of caspase-dependent apoptosis ...not caspase-9, supporting the rationale that apoptosis occur via a ...
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Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
... of apoptosis in human pancreatic cancer cell lines ...the caspase 3 and 8 activity, mitochondrial membrane potential esti- mation and induction of apoptosis was further ...
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Green Tea Polyphenols Mediated Apoptosis in Intestinal Epithelial Cells by a Fadd Dependent Pathway
... Intestinal cells were treated with different concentrations of GrTP (100-400 µg/ml) or EGCG and EGC (10-500 µM) for a period of 24 h. Cell viability and death were determined with trypan blue exclusion and confirmed with ...
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CXC receptor 2 knockout genotype increases X linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity
... that apoptosis is important in the APAP-induced liver injury in this model, additional experiments were performed with the pancaspase in- hibitor ...preventing apoptosis than other inhibitors, such as ...
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TAZ inhibition promotes IL-2-induced apoptosis of hepatocellular carcinoma cells by activating the JNK/F-actin/mitochondrial fission pathway
... Finally, we confirmed that IL-2/TAZ regulates mito- chondrial fission by activating the JNK/F-actin path- way. In our study, inhibition of the JNK/F-actin pathway abolished IL-2/TAZ-induced effects on mitochondrial ...
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Phosphatidylinositol 3-kinase inhibitor(LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo
... B(Akt) to the plasma membrane [2,3]. Akt is phosphory- lated at two sites, T308 in kinase domain and S473 in reg- ulatory tail. Phosphorylation at T308 and S473 is essential for maximal Akt activation [2,3]. Phosphory- ...
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Human Immunodeficiency Virus Type 1 Envelope gp120-Induced Partial T-Cell Receptor Signaling Creates an F-Actin-Depleted Zone in the Virological Synapse
... tripetally to form the cSMAC. As in the IS, the formation and centripetal transport of the gp120 MCs are actin dependent, as they are sensitive to inhibitors of actin polymerization. Unlike the TCR MCs (71), once ...
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Activation of Caspase-2 in Apoptosis
... during Apoptosis— Members of the caspase family are synthesized as precursors of approximately 45–50 ...whether caspase-2 is cleaved and activated when cells undergo apopto- sis, a rabbit polyclonal ...
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Apoptosis in Caspase-inhibited Neurons
... ferent caspase isoenzymes varies greatly ...systems caspase-2 in particular, appeared to be inactivated at a considerably slower rate than all other caspases ...Since caspase-2 may have a role in ...
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Overexpression of 7a, a Protein Specifically Encoded by the Severe Acute Respiratory Syndrome Coronavirus, Induces Apoptosis via a Caspase-Dependent Pathway
... induce apoptosis, which has been observed ...induces apoptosis. 7a induces apoptosis via a caspase-dependent pathway and in cell lines derived from different organs, including lung, ...
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