Caspase-independent
Endonuclease G takes part in AIF-mediated caspase-independent apoptosis in Mycobacterium bovis-infected bovine macrophages
... blocks caspase-independent apoptosis induced by ...of caspase activation and suggested that AIF might be involved ...that caspase activity is not required to decrease Myco- bacterial ...
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A caspase independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection
... both caspase-dependent and caspase-independent apoptosis or to necrosis, depending on the type of cell and the stimulus involved ...of caspase-8 or caspase-10, death receptor ligation ...
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Hepatitis C virus core protein induces apoptosis like caspase independent cell death
... the caspase inhibitor zVAD-fmk in contrast to that observed for mito- mycin C or ...of caspase activation since the internucleo- somal cleavage of DNA is mainly due to the activity of CAD ...
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Mitochondrial p53 phosphorylation induces Bak-mediated and caspase-independent cell death
... in caspase-3 cleavage and cell death (Supplementary Figure 2A). Caspase-3 activation and cell death, however, were impeded in the presence of zVAD (Supplementary Figure 2A and 2B), as previously reported ...
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Gentian extract induces caspase independent and mitochondria modulated cell death
... tochondrial membrane; it inhibits proton transport from intermembrane space into matrix and ATP synthesis, re- sulting in increased (Figure 2(c), right). As shown in Figure 2(c) (left), increased in Y3-Ag1.2.3 cells ...
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Reovirus Activates a Caspase Independent Cell Death Pathway
... In a variety of cell lines, prototype type T3 reovirus strains, T3D and T3A, induce significantly more apoptosis than the type T1 reovirus strain T1L (30–34). In this study, we investigated how T3 and T1 reovirus strains ...
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Original Article 3-aminobenzamide, one of poly(ADP-ribose) polymerase-1 inhibitors, rescuesapoptosisin rat models of spinal cord injury
... Interestingly, caspase-3 was not significantly altered with or without ...in caspase-independent way, which could provide a better therapeutic target for the treatment of ...
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Rudy, Anita (2007): Unusual apoptotic signaling pathways in cancer cells induced by cephalostatin. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Although caspase-mediated apoptosis is the underlying cell death program in many settings, it is unlikely that this mechanism is the only protection of an organism against unwanted and potentially harmful ...
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Role of Apoptosis Inducing Factor (AIF) as Risk Factors of Premature Rupture of Membranes
... through caspase independent pathway, if the cell is triggered by the apoptosis, then AIF and endonuclease G will translocated from mitochondria to nucleus and causing fragmentation of nuclear ...apoptosis ...
6
Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagy
... and II LC3 (LC3-II). LC3-II increased obviously within 12 hours after reversine treatment both in OC2 and OCSL cells (Figure 5B). Interestingly, the pattern of LC3 in OC2 and OCSL cells under normal condition was dif- ...
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The Human Cytomegalovirus UL36 Gene Controls Caspase-Dependent and -Independent Cell Death Programs Activated by Infection of Monocytes Differentiating to Macrophages
... of caspase-indepen- dent cell ...prevents caspase-independent cell death and promotes infected-cell survival in monocytes at late stages of macrophage ...
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Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase
... induce caspase-independent apoptosis, we speculate that the decrease in PARG levels enhances the auto-PARylation-mediated inhibition of PARP, thereby avoiding premature death of the infected ...
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Anticancer properties and enhancement of therapeutic potential of cisplatin by leaf extract of Zanthoxylum armatum DC.
... a caspase independent ...enhanced caspase activation that plays a significant role in the synergistic interaction among chemotherapeutic drugs and ...
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A Novel Cell Death Gene Acts to Repair Patterning Defects in Drosophila melanogaster
... of caspase-independent cell death, Mabiki (Mabi), that is involved in the repair of the head patterning defects caused by extra copies of bicoid in Drosophila ...with caspase-dependent cell death ...
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Drug-induced amino acid deprivation as strategy for cancer therapy
... Induced caspase-independent apoptosis and autophagy in bladder cancer cell lines in vitro and reduced tumor growth and in vivo (s.c4. ASS1-ve due to methylation may be related poor progn[r] ...
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Conditional deletion of caspase 8 in macrophages alters macrophage activation in a RIPK dependent manner
... that caspase-8–deficient macrophages are prone to a caspase-independent death in response to DR ligation; yet, caspase-8–deficient myeloid populations are not predisposed to unchecked ...
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Caspase-3-Dependent and -Independent Apoptosis in Focal Brain Ischemia
... of caspase-3 activation 24 h after onset of ischemia (A, B) and in the areas with caspase-3-independent apoptosis 72 h after onset of ischemia (A’, ...in caspase-3 positive and ...
6
NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus
... stable caspase-2 BiFC reporter cell ...the caspase-2 BiFC components are expressed at equal levels as they are translated from a single mRNA ...of caspase-2 BiFC, identifying a novel class of ...
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Caspase 3 and caspase 8 expression in breast cancer: caspase 3 is associated with survival
... min. Caspase-3 and -8 staining were achieved using a Vectastain Universal Elite ABC Kit (Vector Labora- tories, USA) and a Novolink Polymer Detection System (Leica, Denmark) following the manufacturers’ protocols, ...
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Heliothis zea Nudivirus 1 Gene hhi1 Induces Apoptosis Which Is Blocked by the Hz-iap2 Gene and a Noncoding Gene, pag1
... siently transfected Sf-21 cells. It has been reported that some virus-encoded transcription factors, such as baculovirus IE1 and human immunodeficiency virus Tat, are proapoptotic, whereas some DNA viruses trigger ...
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