Castleman Disease
Update and new approaches in the treatment of Castleman disease
... ago, Castleman disease comprises a rare and heterogeneous cluster of disorders, characterized by lymphadenopathy with unique histological features and associated with cytokine-driven constitutional symptoms ...
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Castleman disease of the hyaline vascular variant transforming to POEMS syndrome as endpoint: a case report
... with Castleman dis- ease without any clinical evidence of POEMS ...ical Castleman disease variant of POEMS syndrome has no clonal PCD and typically little to no peripheral neur- opathy, therefore ...
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Case Report Castleman disease variant of POEMS syndrome complicated with multiple cerebral infarction: a rare case report and review of literature
... remarkable elevated pressure of the cerebro- spinal fluid (CSF), which exceeded 330 mm H 2 O. CSF analysis revealed slightly elevated protein of 0.86 g/L. Magnetic Resonance Imaging (MRI) of the brain revealed a medium- ...
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Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL 6 blockade–refractory idiopathic multicentric Castleman disease
... Multicentric Castleman disease (MCD) is characterized by poly- clonal lymphoproliferation, hypervascularized lymph nodes con- taining dysmorphic germinal centers, cytokine-driven systemic inflammation, ...
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Case Report Primary Castleman disease in peripancreatic tissue regarded as pancreatic malignance: a case report
... Castleman disease (CD), first described in 1954 [1], is a rare lymphoproliferative disorder which is commonly found in mediastinum [2, 3]. After then, more and more other locations of CD were found [4, 5]. ...
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HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease.
... In 1994, a previously unrecognized g-herpesvirus was discov- ered by Chang and Moore [1] with use of representational difference analysis to identify DNA fragments of this virus from Kaposi sarcoma (KS) tissue samples. ...
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Primary hyaline vascular Castleman disease of the kidney: case report and literature review
... Castleman disease is a rare nonneoplastic lymphoprolif- erative disorder that was first described more than 60 years ago by Castleman as a benign, localized lump or mass ...the disease has ...
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Iron-Deficiency Anemia in Castleman Disease: Implication of the Interleukin 6/Hepcidin Pathway
... Castleman disease (CD) is a rare lym- phoproliferative disorder with 3 histo- logic variants (hyaline vascular, plas- macytic, and mixed-cellularity type) and 2 clinical presentations (localized and ...
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Extranodal Castleman Disease of Lower Extremities: A Case Report of a Rare Presentation
... The Castleman disease (CD) is a rare condition defined as benign proliferation or hyperplasia of the angiofollicu- lar lymph ...this disease is reported more in patients with HIV in- ...
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Case Report Multicentric Castleman disease as a rare cause of nephrotic syndrome: a case report
... Abstract: Castleman disease (CD) is a benign lymphoproliferative disorder that is clinically divided into two types: multicentric Castleman disease (MCD) and unicentric Castleman ...
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Case Report Clinical and radiological features of parapancreatic hyaline-vascular Castleman disease: a case report and literature review
... Castleman disease (CD) is an uncommon lym- phoproliferative disorder of unknown origin that usually affects both lymph nodes and non-nod- al tissue, initially described as a pathological entity in 1954 and ...
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Multicentric Castleman Disease in an HHV8-Infected Child Born to Consanguineous Parents With Systematic Review
... Histologic features of axillary lymph node sections from our patient. Pathologic analyses showed lymph nodes with abnormal germinal centers of variable size and shape, and atretic follicles with prominent hyalinization ...
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Clinical spectrum of intrathoracic Castleman disease: a retrospective analysis of 48 cases in a single Chinese hospital
... Castleman disease (CD) is also known as angiofollicular hyperplasia or giant lymph node hyperplasia. It can be classified as unicentric (unifocal or localized) or multi- centric (multifocal or generalized) ...
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Hyaline vascular variant of unicentric Castleman disease of the tonsil: a case report
... vascular Castleman disease (HVCD) type accounts for 90% of cases and most commonly presents as a mediastinal nodal mass ...cell Castleman disease (PCCD) is observed in an older population, ...
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SpyGlass DS -Directed Radiofrequency Ablation with Double Biliary Metal Stent Placement for Managing Recurrent Obstructive Jaundice Secondary to Castleman Disease: A Case Report of a Rare Disease (with Videos)
... Castleman disease (CD) rarely presents with obstructive jaundice, which poses a diagnostic and therapeutic challenge to the management of the disease. A 40-year-old man was referred to our hospital ...
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Case Report Indolent T-lymphoblastic proliferation associated with Castleman disease and low grade follicular dendric cell sarcoma: report of a case and review of literature
... vascular Castleman disease (HV-CD) and low grade follicular dendric cell sarcoma ...indolent disease, requiring no treatment, often associated with other ...
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Possible roles of Epstein-Barr virus in Castleman disease
... tleman disease studied by IHC stain and in situ hybridiza- ...with Castleman dis- ...During disease progression, these EBV-infected lym- phocytes shifted from predominantly intra-follicular areas ...
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A phase 2, open-label, multicenter study of the long-term safety of siltuximab (an anti-interleukin-6 monoclonal antibody) in patients with multicentric Castleman disease
... with Castleman disease treated in a phase 1 clinical trial [5, ...inflammatory disease parameters in patients with MCD [7] and led to the recent approvals from the Unites States (US) Food and Drug ...
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ADA2 Deficiency Mimicking Idiopathic Multicentric Castleman Disease
... Multicentric Castleman disease (MCD) is a rare entity that, unlike unicentric Castleman disease, involves generalized polyclonal lymphoproliferation, systemic inflammation, and multiple-organ ...
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Emerging treatments in Castleman disease – a critical appraisal of siltuximab
... Abstract: Castleman disease (CD) is a rare, heterogeneous lymphoproliferative disorder for which no standard of care currently ...a disease lacking efficacious ...
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