catalytic subunit
Autoantibodies to DNA dependent protein kinase Probes for the catalytic subunit
... of 302 patients without anti–DNA-PKcs antibodies had this specificity ( P , 0.01). We cannot exclude the possibility that both autoantibody specificities occur independently in the same disease subset. However, it seems ...
6
The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells
... The telomerase holoenzyme is composed of a number of proteins involved in the assembly, processing and stability of the complex in vivo [reviewed in 5, 6]. The two main subunits of this ribonucleoprotein, the reverse ...
18
Exploring the roles of the C terminal of Pol2, the catalytic subunit of DNA Polymerase ɛ, in replication and checkpoint response
... ε’s catalytic subunit, Pol2, is essential for its ...B subunit, Dpb2, physically linking it to the helicase component, GINS, and thereby being instrumental in the formation of the pre-LC during ...
236
Cdc55p-Mediated E4orf4 Growth Inhibition in Saccharomyces cerevisiae Is Mediated Only in Part via the Catalytic Subunit of Protein Phosphatase 2A
... B subunit-dependent pathway in E4orf4-induced growth inhibition comes from our results with DEY3 cells expressing the PP2A catalytic subunit mutant ...PP2A catalytic subunit con- ...
12
Homology modeling and structural analysis of human γ glutamylcysteine ligase catalytic subunit for antitumor drug development
... GCL catalytic subunit (GCLC) mRNA and GCL activity have been fre- quently observed in cells derived from human tumors re- sistant to chemotherapeutic agents ...
11
Pin1 Interacts with the Epstein-Barr Virus DNA Polymerase Catalytic Subunit and Regulates Viral DNA Replication
... polymerase catalytic subunit, BALF5, as a Pin1 substrate in glutathione S-transferase (GST) pulldown and immunoprecipitation ...BALF5 subunit interacts with Pin1 through BALF5 Thr178 in a ...
8
Genetic Interactions Between REG1/HEX2 and GLC7, the Gene Encoding the Protein Phosphatase Type 1 Catalytic Subunit in Saccharomyces cerevisiae
... Mutations in GLC7, the gene encoding the type 1 protein phosphatase catalytic subunit, cause a variety of abberrant phenotypes in yeast, such as impaired glycogen synthes[r] ...
9
The MyD116 African Swine Fever Virus Homologue Interacts with the Catalytic Subunit of Protein Phosphatase 1 and Activates Its Phosphatase Activity
... the catalytic subunit of protein phosphatase 1 (PP1) interacts specifically with the ASFV DP71L protein in a yeast two-hybrid ...␣ catalytic subunit expressed as a histidine fusion protein (6 ...
7
The archaeo eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain
... primase subunit is less clear but experiments suggest that this protein might have a role in determining (or limiting) the length of the RNA primer synthesised by the catalytic subunit ...PriS-PriL ...
6
The Epstein-Barr Virus Pol Catalytic Subunit Physically Interacts with the BBLF4-BSLF1-BBLF2/3 Complex
... Pol catalytic and the BMRF1 Pol accessory subunits, the putative helicase-primase complex, comprising the BBLF4, BSLF1, and BBLF2/3 proteins, and the BALF2 single-stranded DNA-binding ...accessory subunit ...
8
The AMP activated protein kinase α2 catalytic subunit controls whole body insulin sensitivity
... metabolism. To better understand the physiological role of AMPK, we generated a knockout mouse model in which the AMPKa2 catalytic subunit gene was inactivated. AMPK a 2 –/– mice presented high glucose ...
9
Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients
... Results: Seventy seven single nucleotide polymorphisms (SNPs) from 14 candidate genes were genotyped and assessed for association with SMX-induced hypersensitivity, in a cohort of 171 HIV/AIDS patients. SNP rs761142 T ...
9
Protein kinase CK2 catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma
... Protein kinase CK2 alpha (CK2α), one isoform of the catalytic subunit of serine/ threonine kinase CK2, has been indicated to participate in tumorigenesis of various malignancies. We conducted this study to ...
18
Molecular Identification of a Calcium-Inhibited Catalytic Subunit of Casein Kinase Type 2 from Paramecium tetraurelia
... the catalytic ␣ subunit of CK2, which suggests the existence of a multigene family for this ...two catalytic (␣ and ␣⬘) and two regulatory () subunits in various compositions (1, 9, ...ulatory ...
14
A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus
... Western blot analysis. For direct blotting of crude extracts, approximately 50 g of total protein was transferred onto a polyvinylidene difluoride (PVDF) membrane (Bio-Rad) following SDS-PAGE electro- phoresis and ...
16
Cellular role of the V ATPase in Neurospora crassa: analysis of mutants resistant to concanamycin or lacking the catalytic subunit A
... four uncharacterized genes can also confer resistance. Inactivation of the V-ATPase by disruption of vma-1, which encodes the catalytic subunit (A) of the enzyme, causes a much more severe phenotype than ...
10
Further characterization of the interaction between the Epstein-Barr virus DNA polymerase catalytic subunit and its accessory subunit with regard to the 3'-to-5' exonucleolytic activity and stability of initiation complex at primer terminus.
... 5 0022-538X/94/$04.00+0 Copyright ©D 1994, American Society for Microbiology Further Characterization of the Interaction between the Epstein-Barr Virus DNA Polymerase Catalytic Subunit a[r] ...
10
The Pre-NH2-Terminal Domain of the Herpes Simplex Virus 1 DNA Polymerase Catalytic Subunit Is Required for Efficient Viral Replication
... (catalytic subunit UL30 [Pol] and processivity factor UL42), sin- gle-stranded DNA binding protein (SSB; ICP8), and the helicase- primase complex (UL52, UL5, and UL8) (2, ...
9
IDENTIFICATION OF HUMAN cAMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT INHIBITORS
... kinase catalytic subunit caused tumorgenesis in ...kinase catalytic subunit, a high throughput virtual screening of zinc natural compounds database was ...
6
Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family
... PI3K catalytic subunit p110β contributes to increased S6 phosphorylation in lymphoblastoid cell lines from patients with FXS ...PI3K catalytic subunit. In contrast to FXS, the PI3K ...
12