cathepsin B/L
Gewies, Andreas (2004): Investigation of the ubiquitin-specific protease UBP41 and of the lysosomal cysteine proteases cathepsin-L and cathepsin-B as potential mediators of proapoptotic signalling. Dissertation, LMU München: Fakultät für Biologie
... mouse cathepsin-L. When murine or human cathepsin-L was overexpressed in 293T or HeLa cells, a minor fraction of cells displayed a small and round phenotype resembling ...of ...
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Thyroid functions of mouse cathepsins B, K, and L
... Cathepsins B, K, and L are expressed in the thy- roid of all species analyzed so far, including humans (2, ...the cathepsin K–deficient mouse has already proved to be a valuable animal model for the ...
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Specialized roles for cysteine cathepsins in health and disease
... human cathepsin proenzymes. Mouse cathepsin L, human cathepsin V, and human cathepsin L are compared with each other and with human and mouse cathepsin B in order ...
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Mutant Cells Selected during Persistent Reovirus Infection Do Not Express Mature Cathepsin L and Do Not Support Reovirus Disassembly
... in cathepsin L maturation exhibited by mutant cells selected during persistent reovirus infection likely results from an alteration of a protein specifically required for cathep- sin L activation or ...
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ION EXCHANGERS: A USEFUL TOOL FOR SEPARATION AND SIMULTANEOUS PURIFICATION OF LYSOSOMAL CYSTEINE PROTEINASES, CATHEPSINS B, H AND L
... of Cathepsin B, H and L using different steps as detailed ...above. Cathepsin B, H and L activities were assayed using BANA, Leu-2- NNap, Z-Phe-Arg-NNapOMe at pH ...respectively. ...
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Cathepsin B: a potential prognostic marker for inflammatory breast cancer
... Tissue sections were prepared from paraffin blocks and stained with hematoxylin and eosin to select tissue sec- tions for immunostaining and scoring. IHC staining for each marker was performed in duplicate on 5 μm thick ...
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Differential sialotranscriptomes of unfed and fed Rhipicephalus haemaphysaloides, with particular regard to differentially expressed genes of cysteine proteases
... Subsequently, cathepsin B (CATB) and cathepsin L (CATL) participate in the secondary digestion, to generate smaller ...and cathepsin C (CATC), small fragments are degraded into ...
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Extracellular cathepsin L stimulates axonal growth in neurons
... while cathepsin B-null mice did not have an obvious phenotype ...of cathepsin L and cathepsin B clearly demonstrated a brain-specific phenotype, such as neuronal death in the ...
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Evolutionary History of Cathepsin L (L-like) Family Genes in Vertebrates
... cathepsin B family even earlier than the differentia- tion between plants and fungus ...the L, S, and K members of cathepsin L family evolved from a common ancestral gene prior to ...
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Cathepsin L increases invasion and migration of B16 melanoma
... extracellular cathepsin L since extracellular matrix degradation by cathepsin L is known to ...to cathepsin involvement in tumor cell migration comes from a study of cathepsin ...
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The mRNA expression and enzymatic activity of three enzymes during embryonic development of the hard tick Haemaphysalis longicornis
... epsins B [9] and L [32], serine proteases [10], aspar- tic proteases [15] and acid phosphatases ...them, cathepsin B, cathepsin D and acid phosphatase have been frequently ...of ...
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Virtual screening and molecular docking of Anti-Antileishmanial for selected pharmacophore for visceral Leishmaniasis
... Leishmaniasis, Cathepsin like cysteine protease is an important target protein for the identification of novel lead compound of ...Leishmaniasis. Cathepsin like cysteine protease representing a major ...
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Exploring Leishmania infantum cathepsin as a new molecular marker for phylogenetic relationships and visceral leishmaniasis diagnosis
... The diagnostic marker based on the cathepsin L-like CPA gene has shown high sensitivity and was specific for L. infantum, which enables direct use in clinical samples both in non-endemic areas with ...
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Optical tomographic imaging of near infrared imaging agents quantifies disease severity and immunomodulation of experimental autoimmune encephalomyelitis in vivo
... detect cathepsin and matrix metalloprotease (MMP) activity asso- ciated with inflammation (Cat B 680 FAST TM , ProSense® 750EX and MMPSense® 750 FAST), enzymatic renin activity associated with abnormal ...
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Regulation of Cathepsin D Metabolism in Rabbit Heart: EVIDENCE FOR A ROLE FOR PRECURSOR PROCESSING IN THE CONTROL OF ENZYME ACTIVITY
... both cathepsin D and total cardiac protein synthesis are similar in control and fasted rabbits, suggesting that decreased enzyme degradation rather than increased synthesis is responsible for the elevated levels ...
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Loss of the nuclear pool of ubiquitin ligase CHIP/STUB1 in breast cancer unleashes the MZF1 cathepsin pro oncogenic program
... Figure 5. CHIP levels control the expression of MZF1 target genes cathepsins B and L. (A) EMSA analysis with the CTSB promoter sequence in CHIP-hi vs. CHIP-lo BT474 cells was done as in Figure 4B. ...
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Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
... Cat L is present, its activity could not be detected in ex vivo isolated dendritic cells ...Cat L–deficient NOD ...Cat L–deficient NOD mice retained their ability to infiltrate the endocrine pan- ...
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Elucidating the role of cathepsin B in the lifecycle of influenza A virus
... Influenza virus type A (IVA) is the etiologic agent responsible for the febrile respiratory illness referred to as the flu. Seasonal and occasionally pandemic IVA-associated illness is a significant cause of morbidity ...
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Cathepsin W Is Required for Escape of Influenza A Virus from Late Endosomes
... Notably, we detected two easily separable bands for CtsW on Western blots; the top band could sometimes be observed as a doublet. In contrast, only a single band could be detected for the catalytically inactive mutant. ...
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Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus 2 Release from Cells
... Human HPSE is an endoglycosidase with the distinction of being the only enzyme capable of degrading heparan sulfate (HS) (9–11), an evolutionarily conserved glycos- aminoglycan that is present ubiquitously at the cell ...
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