Cathepsin K
IMMUNOHISTOCHEMICAL EXPRESSION OF CATHEPSIN K IN EPIDERMAL TUMORS.
... tumors, Cathepsin K expression was statistically significantly lower in the benign group (SK and AK) compared to the invasive group (BCC and SCC) (p ...<0.001). Cathepsin K expression was ...
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The selective cathepsin K inhibitor MIV 711 attenuates joint pathology in experimental animal models of osteoarthritis
... Unlike the ACLT model in rabbits and dogs, the par- tial medial meniscectomy model has limited effects on subchondral bone and is more reflective of a model of cartilage degeneration [32, 40]. In the current dog study, ...
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Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage
... stimulate cathepsin K expression in chondrocytes remains to be ...and cathepsin K-generated cleavage of Col ...hand, cathepsin K positive cells have been identified in all zones ...
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Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis
... strategies. Cathepsin K (Cath K) is a member of the lysosomal cysteine and aspartic proteinase family, and has been shown to possess unique collagenolytic activities ...[5]. Cathepsin K ...
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Review Article Safety of the cathepsin K inhibitor odanacatib in postmenopausal women with osteopenia or osteoporosis: a meta-analysis
... Abstract: Cathepsin K, a cysteine protease expressed in osteoclasts, degrades type 1 ...inhibited cathepsin K and rapidly decreased bone resorption in preclinical and clinical ...
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Clinical and animal research findings in pycnodysostosis and gene mutations of cathepsin K from 1996 to 2011
... The candidate gene for pycnodysostosis was mapped to human chromosome 1q21 by genetic linkage analysis, and was subsequently identified as coding for cathepsin K (CTSK, MIM# 601105) by a positional cloning ...
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Cathepsin K in lymphangioleiomyomatosis: LAM cell fibroblast Interactions enhance protease activity by extracellular acidification
... Inhibition of membrane transporters affects 621-101 cell extra-cellular pH and cathepsin K activity.. We then used pharmacological inhibitors of these membrane transporters to determine [r] ...
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Original Article MiRNA-7 targets cathepsin K to inhibit invasion and metastasis of neuroblastoma cells
... Abstract: Background: We aimed to investigate the function of miR-7 in the invasion and metastasis of neuroblas- toma cells and to explore its mechanism. Methods: QRT-PCR or western blot was used to validate the ...
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Cathepsin K–deficient osteocytes prevent lactation induced bone loss and parathyroid hormone suppression
... Cathepsin K (Ctsk) is highly expressed in osteoclasts and is secret- ed in the bone-resorbing compartment, where it degrades the organic bone matrix after dissolution of the mineral phase at low pH during ...
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Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV 711
... epsin K is known to generate these telopeptide crosslinks directly from type I collagen via enzymatic cleavage [29, ...other cathepsin K inhibi- tors that have been investigated in clinical studies ...
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Original Article Cathepsin K inhibitor, icariin, increases the healing potential and biomechanical properties of femoral neck in a mice fractured model
... Bone structure is dynamically maintained by bone remodeling, which is a process balanced by osteoblast-mediated bone formation and osteoclast-mediated bone resorption [1]. Dis- equilibrium of bone remodeling and calcium ...
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Morning vs evening dosing of the cathepsin K inhibitor ONO-5334: effects on bone resorption in postmenopausal women in a randomized, phase 1 trial
... Reductions from baseline in derived total 24-h serum CTX- I AUE were consistent with previous reports on cathepsin K inhibitors, balicatib and odanacatib. In postmenopausal wom- en, serum CTX was reduced by ...
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Antiresorptive effect of a cathepsin K inhibitor ONO 5334 and its relationship to BMD increase in a phase II trial for postmenopausal osteoporosis
... In contrast, ONO-5334 SR formulations most likely maximize the potency of ONO-5334 by reducing Cmax and increasing exposure around the trough [28]. In addition, the flat PK profile of ONO-5334 SR may minimize the ...
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Manuscript Title- Potential Role of Cathepsin K in Regulation of Micro Tumor Environment, Onset and Progression of Cancers in Human- A Review.
... and cathepsin K within the ...of cathepsin K that is functional within the gastric cancerous cells, that their invasiveness and tumor progression is ...of cathepsin K in the ...
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Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA
... Please cite this article as: Nwosu LN, Allen M, Wyatt L, Huebner JL, Chapman V, Walsh DA, Kraus VB, Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of ...
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Original Article Cathepsin K in the immunohistochemical diagnosis of melanocytic lesions
... osteoclastic cathepsin K ...of cathepsin K [25]. In addition, cathepsin K inhib- itors are being developed for cancer therapy in bone metastases, for rendering the bone a less ...
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The effect of cathepsin K deficiency on airway development and TGF-β1 degradation
... Sections were incubated with 1% bovine serum albumin for 30 min at room temperature and subsequently incu- bated at 4°C overnight with mouse anti cathepsin K (1H6: 1:100 dilution, produced by Dr. E. Weber), ...
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Cathepsin K analysis in a pycnodysostosis cohort: demographic, genotypic and phenotypic features
... Pycnodysostosis is a rare autosomal recessive disorder char- acterized by short stature, acroosteolysis of the distal pha- langes, clavicular dysplasia, osteosclerosis with increased bone fragility, and delayed closure ...
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Expression of the Proteinase Specialized in Bone Resorption, Cathepsin K, in Granulomatous Inflammation
... In this work we present evidence for the as- sociation of cathepsin K with a granulomatous reaction. Granulomas are tissue reactions typi- cally elicited by persistent, indigestible patho- gens, pathogen ...
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Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor κB ligand
... Cathepsin K is a recognized component of osteoclasts, where it plays a central role in bone resorption ...inducing cathepsin K pro- duction. This aspect of the biology of cathepsin ...
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