Cation transporter
calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues
... Genetic studies have revealed a key role for InR signalling in coordinating growth and other nutrition-regulated functions in flies. Although the distinct elements of this pathway have been well described, the downstream ...
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Original Article Organic cation transporter 2 and tumor budding as independent prognostic factors in metastatic colorectal cancer patients treated with oxaliplatin-based chemotherapy
... We evaluated the correlation of OCT2 and TB levels with clinicopathological findings (Table 1). High OCT2 levels were significantly associ- ated with depth of invasion (more frequently in tumors with serosal invasion, ...
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Treatment of attention deficit hyperactivity disorder with monoamine amino acid precursors and organic cation transporter assay interpretation
... Background: This paper documents a retrospective pilot study of a novel approach for treating attention deficit hyperactivity disorder (ADHD) with amino acid precursors of serotonin and dopamine in conjunction with ...
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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
... Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of the drug, which involve activation of AMP-activated protein kinase (AMPK), is ...
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Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury
... To investigate the change in expression of MATE1/ SLC47A1, human proximal tubular epithelial cells were incubated for 24 hours in serum-free renal epithelial cell [r] ...
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Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates
... In addition, when MATE1 and MATE2-K were trans- duced in HEK293 cells this resulted in a small significant uptake of PG by MATE1. When CG was used as poten- tial substrate, uptake by MATE1 and MATE2-K was clearly ...
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Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1
... Several population genetic analyses pointed to a pressure for maintaining OCT1 activity in East Asia and Oceania. First, and most important, the observed loss-of-function variability in East Asia and Oceania was ...
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DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
... radioembolization and oncolytic approaches. Currently, there are more than 150 ongoing clinical trials. But, in the main, these are not integrating information about the molecular pathogenesis of HCC [2]. For instance, ...
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Stress regulated members of the plant organic cation transporter family are localized to the vacuolar membrane
... The human solute carrier family 22, (SLC 22), is a gene family that contains organic cation transporters (OCTs), zwitterions/cation transporters (OCTNs) and organic anion transporters (OATs,) with 11–12 ...
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Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders
... Creatine transporter (CRT/solute carrier (SLC) 6A8) expressed at the BBB regulates creatine concentration in the brain, and represents a major pathway for supply of creatine from the circulating blood to the ...
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Pharmacogenetics of metformin response: a step in the path toward personalized medicine
... Type 2 diabetes mellitus affects 9.6% of the adults in the United States and more than 200 million people worldwide. Diabetes can be a devastat- ing disease, but it can now be treated with nine classes of approved drugs ...
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Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes mellitus: a systematic review protocol
... The precise molecular mechanisms underlying met- formin’s action are not well understood. It was initially suggested that one of the key actions of metformin is to activate AMP-activated protein kinase (AMPK) through a ...
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The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis
... In this “case” study, we report the functional characterization of the zebrafish PepT1a-type transporter, which completes the functional picture of the triad of PepT- type transporters, i.e., PepT1a (Slc15a1a), ...
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Dynamic interaction of genetic risk factors and cocaine abuse in the background of Parkinsonism – a case report
... of swallow tail sign was detected (Fig. 1), suggesting Parkinson’s disease. For further clarification DaTscan was performed by a double-headed SPECT system (GE Infinia II with Xeleris workstation) using a standard ac- ...
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Effects of galacto-oligosaccharides on growth and gut function of newborn suckling piglets
... studies, the lactase activity on d 21 was lower than that on d 8, and the sucrase and maltase activities on d 21 were higher than those on d 8. It is known that maltase and sucrase activities are important markers to ...
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<p>Role of OCT1 in hepatocellular carcinoma</p>
... Also, OCT1 expression in various tumor cells has been demonstrated, such as HCC cells, lung cancer cells, and lymphoma cells. 56–59 Signi fi cant down-regulation of OCT1 expression was detected in a variety of liver ...
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Association analysis of the SLC22A11 (organic anion transporter 4) and SLC22A12 (urate transporter 1) urate transporter locus with gout in New Zealand case control sample sets reveals multiple ancestral specific effects
... classifi- cation criteria for gout, a superior ascertainment method [30] (although the NZ cases were ascertained by clinical examination whereas the incident ones by a self-adminis- tered questionnaire ...
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Conserved tyrosine 147 plays a critical role in the ligand gated current of the epithelial cation/amino acid transporter/channel CAATCH1
... a holding potential of –60 mV. CAATCH1-associated net ionic currents (∆I) were obtained by subtracting control current values measured in the absence of amino acids from currents measured in their presence. It should be ...
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Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood–brain barrier model
... this transporter actively transports oxycodone and diphen- hydramine into the brain, and their unbound concentration in brain interstitial fluid (ISF) is 3- to 5-fold higher than that in blood ...this ...
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Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd Ameliorates hyperuricemia and acute gouty arthritis in animal model
... URAT1, GLUT9 and OAT1. URAT1, which is located in the brush border membrane of the renal tubular epithelial cell is responsible for reabsorption of urate transporter. This protein is encoded by the SLC22A12 gene, ...
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