CB1/2
The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats
... We first tested whether acute administration of the CB1 cannabinoid receptor agonist WIN-55,212-2 alters L-DOPA- induced motor fluctuation. At day 1, 7, 14, 21, and 22, L- DOPA-induced motor responses were ...
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Orchestrated activation of mGluR5 and CB1 promotes neuroprotection
... Following drug stimulation, neurons were lysed in RIPA buffer (0.15 M NaCl, 0.05 M Tris-HCl, pH 7.2, 0.05 M EDTA, 1 % nonidet P40, 1 % Triton X-100, 0.5 % so- dium deoxycholate, 0.1 % SDS) containing protease in- ...
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Cannabinoid CB1 Transmission in the Mesolimbic Reward Pathway
... are CB1 and CB2 cannabinoid receptor (CB1R and CB2R ...of CB1 or CB2 receptors generally blocks adenyl cyclase, and hence prevents signaling through cyclic ...are 2-arachidonoylglycerol (2- ...
157
Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis
... tissue, and low expression of iNOS is associated with reduced risk of death (13). Furthermore, iNOS inhibi- tors have antifibrotic activity in animal models of PF (14, 15), making iNOS a viable therapeutic target for PF. ...
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Interaction Between L-Type Calcium Channels and Antagonist of Cannabinoid System on Anxiety in Male Rat
... cannabinoid CB1 receptors are particularly well-represented in the cortex (entorhinal and cingulate), hippocampus, lateral septum, nucleus accumbens, amygdala, and peri-aqueductal gray area (PAG) ...Furthermore, ...
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Interaction of CB1 receptor agonist arachidonylcyclopropylamide with behavioural sensitisation to morphine in mice
... 2012; Herrera et al. 2013; Hutchinson et al. 2014; Jing et al. 2014), cannabinoids (Rubino et al. 2001; Rubino et al. 2003; Cadoni et al. 2008), opioids (Vanderschuren and Kalivas 2000; Farahmandfar et al. 2011a; Hofford ...
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Pharmacodynamics of cannabinoids
... called CB1 receptors [7]. The cannabinoid CB1 receptor was originally discovered in the central nervous system (in the cortex, basal ganglia, hippocampus, hypothalamus, cerebellum, spinal cord, spinal cord ...
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Jacob, Wolfgang (2007): Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality. Dissertation, LMU München: Fakultät für Biologie
... The object recognition test was performed in the dark phase of the animals’ light/dark cycle. Experimental subjects were habituated to the test arena (a Makrolon Type I cage, 36 x 22 x 14 cm, with sawdust bedding ...
156
Synthesis and Development of Potential CB1 Receptor Neutral Antagonists
... and 2-AG (7), are produced from the metabolism of membrane phospholipids and are released immediately into extracellular ...for 2-AG (7). 13 AEA and 2-AG can be re-synthesized as ...
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Design and Synthesis of CB1 Receptor Ligands and Synthesis of Amphibian Alkaloids
... 30 was refluxed in concentrated hydrochloric acid for 12 hours. Hydrolysis of two ester groups, one amide, and dehydrogenation all proceeded concomitantly giving the α,β-unsaturated carboxylic acid 31. The acid 31 ...
131
CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice
... Women’s hsa-miRNAs and quantification. Women’s blood samples were obtained from volunteers who intended to take a health exam- ination in Healthcare Management Center, Xijing Hospital, Fourth Military Medical University. ...
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The Endocannabinoidome
... using CB1, CB2, and TRPV1 antagonists, along with receptor knockout models to see if there are any effects on the ability of the molecule to mitigate TBI damage (Mann et ...
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Cannabinoid based drugs targeting CB1 and TRPV1, the sympathetic nervous system, and arthritis
... Rheumatoid arthritis (RA) is a debilitating disease that affects around 1.3 million people in the US alone [1]. Important characteristics of RA are inflammation of the joint with subsequent destruction of cartilage, ...
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Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages
... of CB1 in adipocytes or whether it is merely an effect of the lack of obesity, we character- ized SD-fed Ati-CB1–KO mice at 2 weeks after tamoxifen-induced genetic deletion of CB1 in ...
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The role of CB1 in intestinal permeability and inflammation
... of 2-AG in human colonic tissue has not yet been ...and 2-AG concentrations in human colonic tissue. AEA and 2-AG therefore are likely to have dual roles as anti-inflammatory and pro- permeability ...
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Feeding induced by cannabinoids is mediated independently of the melanocortin system
... (a CB1-R agonist) increased food intake and central a-MSH decreased food intake, but that THC-induced feeding was not inhibited by a- MSH ...a CB1- R antagonist (SR 141716) reduced food intake induced by a ...
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The endogenous cannabinoid system protects against colonic inflammation
... thetic cannabinoids have been shown to possess antinociceptive and anti-inflammatory activities (6–8). For millennia, Cannabis preparations have been used in folk medicine for the treatment of a wide variety of ...
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Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet induced obesity
... RT-PCR analyses. Total RNA was isolated from liver and adipose tissue using TRIZOL and reverse-transcribed using the SuperScript First-Strand Synthesis System, in accordance with the manufacturer’s instructions ...
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Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats
... Western blotting was performed to compare the expres- sion levels of CB and CB2 receptors in the urothelium and detrusor muscle layer in rats from each group. Fro- zen tissue samples were pulverized and then homoge- ...
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The Endocannabinoid, 2 Arachidonoyl Glycerol, Induces Growth Cone Collapse and Neurite Retraction in Growing Peripheral Sensory Neurons
... CB1 receptors (CB1Rs) are widely distributed within the brain including cerebral cortex, hippocampus, basal ganglia, and amygdala, as major targets of exogenous cannabinoids such as THC. Moreover, the most ...
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