CBL-B
conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells
... of CBL and CBL-B in T-cells (Figure 2A, 2B) was expected, the alteration of DN thymocyte populations, a more aggressive phenotype of CD4-Cre mediated DKO mice compared to that of previously described ...
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Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers
... of Cbl-b from the nucleus to the cytoplasm prevented the localization of P-gp to caveolae resulting in the reversal of MDR through the ubiquitination and degradation of ...between Cbl-b ...
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Abrogating Cbl b in effector CD8+ T cells improves the efficacy of adoptive therapy of leukemia in mice
... target Cbl-b. Reducing Cbl-b expression in the relatively low-avidity MelanA-specific clones restored IL-2 production and autocrine proliferation in the absence of exogenous IL-2, functions ...
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MicroRNA-891b is an independent prognostic factor of pancreatic cancer by targeting Cbl-b to suppress the growth of pancreatic cancer cells
... system, Cbl-b can inhibit the activation of T CD8+ cells and the immune killing ability of natural killer (NK) cells to inhibit the inherent anti- tumor immune function of the human body and accelerate the ...
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The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis
... activated B cells (NF-κB), mitogen activated protein kinase (MAPK), phospho- inositide 3 kinase (PI3K)/Akt, and nuclear factor of activated T-cells (NFAT), and ...Casitas B-lineage lymphoma ...
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The ubiquitin ligase Cbl b limits Pseudomonas aeruginosa exotoxin T–mediated virulence
... ligase Cbl-b interacts with the type III–secreted effector exotoxin T (ExoT) and plays a key role in vivo in limiting bacterial dis- semination mediated by ...ligase Cbl-b and Crk, the ...
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Control of Virus-Specific CD8+ T-Cell Exhaustion and Immune-Mediated Pathology by E3 Ubiquitin Ligase Cbl-b during Chronic Viral Infection
... including Cbl-b, Itch, GRAIL, and Tsg101, which participate in causing sub- stantial decreases of activity levels of PLC- ␥ 1 and PKC- , two key factors in the TCR signaling ...of Cbl-b are ...
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<p>Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-ι/FAK Ubiquitination Through the Cbl-b Pathway</p>
... via Cbl-b resulted in cell detachment in gastric cancer MGC803 ...the Cbl-b pathway with PKC- ι involvement in ...with Cbl-b (Figure 7B and ...
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An essential role of CBL and CBL B ubiquitin ligases in mammary stem cell maintenance
... of Cbl and Cbl-b mRNA in organoids generated from DKO basal and luminal cells, excluding the possibility of organoids/acini having arisen from precursors in which floxed Cbl was not deleted ...
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Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy
... of Cbl and Cbl-b promotes HSC ...that Cbl/Cbl-b DKO HSCs, which were competent for engraftment, were impaired in maintaining hematopoiesis over time and during serial ...
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VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease
... in CBL or one of a small set of other genes (such as NF1, N-Ras, PTPN11) that regulate RAS signaling, constituting one form of RASopathies [5, 11], with the disease progression invariably associated with a somatic ...
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Ablation of Cbl b provides protection against transplanted and spontaneous tumors
... demonstrated that Cblb –/– mice, but not WT controls, efficiently rejected inoculated E.G7 and EL4 lymphomas that did not express B7 ligands and that introduction of the Cblb –/– mutation into tumor-prone ataxia ...
9
H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b
... and Cbl-b are well known to be involved in the degradation of tyrosine kinase receptors after their activation by growth factors ...and Cbl-b may contribute to impair the degradation of ...
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The Cbl family of ubiquitin ligases regulates FcεRI expression and mast cell activation
... engagement, Cbl proteins can also ubiquitinate Lyn and Fyn in RBL-2H3 cells ...and Cbl-b act as Ub ligases targeting the ac- tive forms of Lyn, further supporting our previous find- ing that ...
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Mutations of c-Cbl in myeloid malignancies
... of Cbl ubiquitin E3 ligases consists of the ubiquitously expressed proteins c-Cbl and Cbl-b as well as Cbl-c, which occur primarily in epithelial ...All Cbl proteins share an ...
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Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders
... when Cbl and Cbl-b were concurrently deleted in the T cell compartment ...that Cbl proteins associate with a variety of growth factor receptors, their negative regulatory roles towards PTKs ...
6
c-CBL regulates melanoma proliferation, migration, invasion and the FAK-SRC-GRB2 nexus
... Melanoma is one of the most aggressive and lethal forms of skin cancer. Despite recent improvements in targeted therapies, many patients with advanced disease fail to achieve lasting tumor regression. Therefore, it is ...
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Design and Implementation of Area Delay Efficient Booth Multiplier Based on CBL G Narender & Sudhir Dakey
... One of the most advanced types of MAC for general- purpose digital signal processing. It is an architecture in which accumulation has been combined with the common Boolean logic (CBL) tree that compresses partial ...
7
Induction of c-Cbl contributes to anti-cancer effects of HDAC inhibitor in lung cancer
... The great success of EGFR tyrosine kinase inhibitor (TKI) in NSCLC with EGFR activation mutation implies the critical role of EGFR in EGFR mutant NSCLC [22, 23]. The efficacy of EGFR TKI is modest in NSCLC without EGFR ...
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Area Efficient Carry Skip Adder Using Ladner Fischer and CBL Architecture for Fastest Addition
... The Modified high speed efficient carry skip adder allow the accurate and high speed addition with minimum delay. The most important advantage of this paper is its ability to add bits with minimum delay this can be done ...
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