CC-chemokine
Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2
... erent chemokine receptors. 1 Chemokine receptors mainly belong to the class A of G protein-coupled receptors (GPCRs) and can be divided into four di ff erent subtypes, namely C, CC, CXC, and CX3C, ...
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Expression of CC chemokine receptor 9 predicts poor prognosis in patients with lung adenocarcinoma
... the CC chemokine receptor family [13], CCR9 may function as an oncogene and play an im- portant role in the tumorigenesis and development of lung ...
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Pivotal role of TARC, a CC chemokine, in bacteria induced fulminant hepatic failure in mice
... identified CC chemokine, MDC, is also a ligand for CCR4 (10), and MDC mRNA was detected in the liver after elicitation by LPS with similar pat- terns as for TARC mRNA expression (data not ...
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Cytomegalovirus CC Chemokine Promotes Immune Cell Migration
... a chemokine fold, as well as a large C-terminal domain that in comparative analyses does not map to any other known protein motif ...tional CC chemokine and to characterize its functional domains, we ...
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Human Cytomegalovirus Inhibits Transcription of the CC Chemokine MCP-1 Gene
... Infection of primary human diploid fibroblasts with HCMV results in the induction of a secreted activity that can induce MCP-1 mRNA expression (Fig. 3). We have not yet identified the activity responsible for this ...
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Differential signaling mechanisms regulate expression of CC chemokine receptor-2 during monocyte maturation
... The chemokine superfamily includes at least 20 receptors and more than 50 ligands [1- ...The chemokine ligands can be separated into two major categories depending on whether they express a CC or CXC ...
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Abrogation of CC chemokine receptor 9 ameliorates collagen induced arthritis of mice
... CCL: chemokine (C-C motif) ligand; CCR: CC chemokine receptor; CIA: collagen-induced arthritis; CII: type II collagen; CMTMR: 5-(and-6)-(((4-chloromethyl)benzoyl)amino) tetramethylrhodamine; DC: ...
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Circulating thymus and activation-regulated chemokine/CC chemokine ligand 17 is a strong candidate diagnostic marker for interstitial lung disease in patients with malignant tumors: a result from a pilot study
... Abbreviations: Kl-6, Krebs von den lungen-6; TaRC/CCl17, thymus and activation-regulated chemokine/CC chemokine ligand 17; nsClC, non-small cell lung cancer; BLD, benign lung disease; I[r] ...
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Blockade of CC chemokine receptor 5 (CCR5) tropic human immunodeficiency virus 1 replication in human lymphoid tissue by CC chemokines
... The CC chemokines MIP-1 a , MIP-1 b , and RANTES sup- press replication of certain HIV-1 strains in cultured PBMC and T cell lines by blocking interaction of gp120 with CC chemokine receptor 5 ...CXC ...
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Lead identification of benzimidazolone and azabenzimidazolone arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists
... chemokine (MDC), and thymus activation-regulated chemokine (TARC) which can recruit Th2 cells from the circulation. The T cells can then migrate along this chemokine gradient to the dendritic cells. ...
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The Role of the CC ‐chemokine receptor 6, CCR6, in B cell differentiation during the humoral immune response
... CCR6 has been implicated in many areas of the immune system including the mucosa and in particular, the intestine. The first reports that described the generation of CCR6 deficient mice, to study the function of CCR6, ...
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CXC and CC Chemokine Receptors on Coronary and Brain Endothelia
... Materials and Methods: The expression of chemokine receptors in human brain microvascular endothelial cells (BMVEC) and coronary artery endothelial cells (CAEC).. in vitro and cryostat s[r] ...
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Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma
... IL-8 is another important inflammatory factor secreted by TAMs in HCC. Its expression is associated with tumor growth and survival, as well as increased tumor invasion, migration and angiogenesis. Studies in MHCC97H and ...
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Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells
... Osteoclasts (OCs) are multinucleated cells with the unique ability to resorb bone. They develop by fusion of hematopoietic precursors belonging to the monocyte/ macrophage lineage. OCs express receptors for two cru- cial ...
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CCR5 ANTAGONIST: A NEW ERA FOR TREATMENT OF AIDS
... a chemokine receptor in the CC chemokine ...natural chemokine ligands that bind to this receptor are RANTES (Regulated upon activation normal T cell expressed & secreted) MIP-1α and ...
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<p>Action of 1,25(OH)<sub>2</sub>D<sub>3</sub> on Human Asthmatic Bronchial Fibroblasts: Implications for Airway Remodeling in Asthma</p>
... described in animal models, 7 but there are no studies on its fibrogenic regulatory effect on HBFCs. In the present study, we show that airway fibroblasts isolated from patients with severe asthma stimulated with TGF-β1 ...
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Imprint of cytomegalovirus and varicella zoster virus infections on the immune system of healthy and diseased subjects
... Acquired Immune Deficiency Syndrome Allophycocyanin Antigen Presenting Cell Brefeldin-A Complete Blood Count CC-Chemokine Receptor 7 Cluster Of Differentiation Cytomegalovirus Cytotoxi[r] ...
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Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
... CCR2: CC-chemokine receptor 2; CCR5: CC- Chemokine receptor 5; CD11b: Cluster of differentiation 11B; CXCR3: CXC-chemokine receptor 3; CXCR4: CXC-chemokine receptor 4; HD: ...
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The Equine Herpesvirus 2 E1 Open Reading Frame Encodes a Functional Chemokine Receptor
... Several herpesviruses contain open reading frames (ORFs) that encode potential homologs of eucaryotic genes. Equine herpesvirus 2 (EHV-2) is a gammaherpesvirus related to other lymphotropic herpesviruses such as ...
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Complementary action of granulocyte macrophage colony stimulating factor and interleukin 17A induces interleukin 23, receptor activator of nuclear factor κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis
... Local production of cytokines and chemokines was mea- sured in joint washouts. The major cytokines produced by arthritic synoviocytes were IL-6, chemokine (C-X-C motif ) ligand 1 (CXCL1), CC ...
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