CCR5-tropic
Infection of Specific Dendritic Cells by CCR5-Tropic Human Immunodeficiency Virus Type 1 Promotes Cell-Mediated Transmission of Virus Resistant to Broadly Neutralizing Antibodies
... cells, CCR5-tropic strains are transmitted more frequently in humans for reasons that are not ...by CCR5-tropic virus, in contrast to mature mDCs, which are not susceptible to infection but ...
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Blockade of CC chemokine receptor 5 (CCR5) tropic human immunodeficiency virus 1 replication in human lymphoid tissue by CC chemokines
... The CC chemokines MIP-1 a , MIP-1 b , and RANTES sup- press replication of certain HIV-1 strains in cultured PBMC and T cell lines by blocking interaction of gp120 with CC chemokine receptor 5 (CCR5). However, the ...
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Induction of CD8+ Cells Able To Suppress CCR5-Tropic Simian Immunodeficiency Virus SIVmac239 Replication by Controlled Infection of CXCR4-Tropic Simian-Human Immunodeficiency Virus in Vaccinated Rhesus Macaques
... pathogenic CCR5-tropic simian immunodeficiency virus (SIV) in rhesus ...on CCR5-tropic SIVmac239 replication in vitro revealed that CD8 ⴙ cells in the chronic phase after SHIV challenge ...
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Pathogenic infection of Macaca nemestrinawith a CCR5 tropic subtype C simian human immunodeficiency virus
... a CCR5- tropic subtype C SHIV-1157ipd3N4 (also referred to as SHIV-C for short), which has been shown to be highly replication-competent and mucosally transmissible in Indian- and Chinese-origin rhesus ...
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Pathogenic Consequences of Vaginal Infection with CCR5-Tropic Simian-Human Immunodeficiency Virus SHIVSF162P3N
... challenge in comparison to i.v. or i.r. infection with the same inoculum are in agreement with these earlier studies, further doc- umenting the restrictions on virus transmission and spread im- posed by the vaginal ...
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Estimating the Infectivity of CCR5-Tropic Simian Immunodeficiency Virus SIVmac251 in the Gut
... depleted is calculated by the equation (baseline CD4 ⫺ minimum CD4)/baseline CD4. Note that for illustration, the viral peak for each monkey is used to provide a single data value (diamonds), but all viral load values ...
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Variable Sensitivity of CCR5-Tropic Human Immunodeficiency Virus Type 1 Isolates to Inhibition by RANTES Analogs
... the CCR5 allele (approximately 1% of the Caucasian population) remain un- infected ...of CCR5, rendering peripheral blood mononuclear cells (PBMC) resistant to infection by NSI R5 isolates but still ...
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Monophylogenetic HIV 1C epidemic in Ethiopia is dominated by CCR5 tropic viruses–an analysis of a prospective country wide cohort
... Almost all reports from Ethiopia on co-receptor usage have been done on patients from Addis Ababa or Gon- dar. Our study clinics were distributed all over the coun- try and the highest prevalence of X4 tropic ...
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Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12
... containing CCR5-tropic (R5) primary HIV Envs cloned directly from brain and lymphoid tissues [9,10,14] to determine neutralization sensitivity to sCD4 and mAbs b12 and b6, which recognize neutralizing and ...
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Antigenic Properties of the HIV Envelope on Virions in Solution
... expressing CCR5-tropic envelopes and exhibited efficient virion binding in ...both CCR5-tropic and CXCR4-tropic viruses without exerting neutralizing ...
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Promiscuous use of CC and CXC chemokine receptors in cell-to-cell fusion mediated by a human immunodeficiency virus type 2 envelope protein.
... to CCR5 were isolated by RT-PCR essentially as described previously (43) and cloned into pcDNA1neo for expression in mammalian ...nontagged CCR5 was monitored by a cell-to-cell fusion assay (see below) with ...
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Enhancement of HIV 1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV 1 infection
... co-receptor CCR5 on LP CD4 T ...up-regulated CCR5 expression on LP CD4 T cells whereas gram-positive cell wall lipoteichoic acid did ...of CCR5 by gram- negative HAMB was largely abrogated in CD4 T ...
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HIV 1 cell to cell transmission and broadly neutralizing antibodies
... Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodies.. van M[r] ...
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Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization
... models: CCR5-tropic HIV-1 JR-CSF transcytosis through epithelial cells, HIV-1 JR-CSF attachment on immature monocyte-derived dendritic cells (iMDDC), and infectivity of iMDDC by CCR5-tropic ...
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Pace of Coreceptor Tropism Switch in HIV-1-Infected Individuals after Recent Infection
... defective CCR5 allele and infection with non-R5 variants is ...of CCR5 due to the Δ32 mutation favors infection by non-R5 variants ...were CCR5 heterozygous. One patient (1044) was infected with ...
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Coreceptor Tropism in Human Immunodeficiency Virus Type 1 Subtype D: High Prevalence of CXCR4 Tropism and Heterogeneous Composition of Viral Populations
... switching via mutations in the V3 region is high. In contrast, variants that acquire mutations outside of the V3 region that confer inefficient CXCR4 use without compromising CCR5 use may have an opportunity to ...
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Defining the fitness of HIV-1 isolates with dual/mixed co-receptor usage
... dual tropic HIV-1 outgrowth dur- ing propagations from patient samples typically depends on both the replicative fitness of x4 and r5 HIV-1 ...resistant CCR5 (r5)-using viruses with reduced susceptibility ...
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Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1
... little CCR5 and are resistant to infections by M-tropic HIV-1; upon activation in vitro, they synthesize CCR5 and become susceptible to infec- tion (7, 9, 69, ...Moreover, CCR5 is synthesized ...
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CXCR-4 Is Expressed by Primary Macrophages and Supports CCR5-Independent Infection by Dual-Tropic but Not T-Tropic Isolates of Human Immunodeficiency Virus Type 1
... The reason(s) that macrophage CXCR-4 supports entry of 89.6 but not T-tropic strains may offer important clues about the function of these molecules or their interaction with other components of the cell surface. ...
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Crispr/Cas9 System - A Revolution in Gene Editing
... (2018) Simultaneous Knockout of CXCR4 and CCR5 Genes in CD4+ T Cells via CRISPR/Cas9 Confers Resistance to Both X4- and R5-Tropic Human Immunodeficiency Virus Type 1 Infecti[r] ...
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