CD22 expression on the CLL cells
Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells
... D0, CLL B-cells were stimulated with PMA and CD40L, in combination with the cytokines IL2, IL10 and ...D4, cells were harvested and incubated with IL2, IL6, IL10 and IL15 for 3 ...D7, ...
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Regulation of protein kinase CbetaII (PKCbetaII) gene expression in chronic lymphocytic leukaemia (CLL) cells
... 45 be removed. Sterile scissors and forceps were used to carefully cut the circle of filter paper in which the DNA was blotted. DNA was then eluted from the filter paper with 100 – 500 µl nuclease-free water depending on ...
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High Membrane Cholesterol in CLL B-Cells and Differential Expression of Cholesterol Synthesis Genes in IG GENE- Unmutated vs Mutated Cells
... CD5 expression, membrane cholesterol and anergy in CLL ...M- CLL is meaningful and may correlate with the “lesser anergic state” of the aggressive- subset in comparison to the indolent ...
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Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo
... chemoresistant CLL cells, as shown in fludarabine and bendamustine-treated primary CLL cells, and that was accompanied by the induction of the expression of the anti-apoptotic proteins ...
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Original Article Role of high expression of IL-9 in prognosis of CLL
... high expression of IL-9 in prognosis of CLL Na Chen 1 , Xiao Lv 1 , Peipei Li 1 , Kang Lu 1 , Xin Wang 1,2 1 Department of Hematology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, ...
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The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL)
... of CLL cells in the peripheral blood (PB), with a significantly higher level of expression on M-CLL, rather than U-CLL samples (Porakishvili et ...heterogeneous expression of ...
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CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia
... restricted expression are used as target ...target expression by normal HSCs. CAR-T cells targeting these same antigens provided a more effective approach to eliminate cancer cells expressing ...
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Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL
... promotes CLL survival and growth, 33 and hence its reduction to unmeasurable levels in spontaneously regressing cases suggests a quiescent, possibly anergic state that may lead irreversibly to cell ...sIgD ...
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Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL
... Mcl-1 expression in CLL cells is also supported by the evidence that the combined Notch1/2 downregulation induces a higher reduction of Mcl-1 levels than that induced by downregulating each single ...
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Clinical relevance of Flt1 and Tie1 angiogenesis receptors expression in B-cell chronic lymphocytic leukemia (CLL)
... The expression and production of VEGF and bFGF have been documented in numerous solid tumors and hematopoietic ...increased expression of cellular VEGF in the leukemic cells of patients with chronic ...
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CLL Exosomes Modulate the Transcriptome and Behaviour of Recipient Stromal Cells and Are Selectively Enriched in miR-202-3p
... of CLL-derived exosomes on human stromal cell behaviour showed that these EVs perturb gene expression within, and enhance proliferation of, target recipient stromal ...that CLL-derived exosomes have ...
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A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment
... dyskerin expression correlates with poor OS following chemotherapy (Figure ...DKC1 expression leads to an imbalance in ribosomal proteins and when entering lymph nodes, these changes are likely to influence ...
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Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival
... these cells do not lose their ability to move toward a protective ...on CLL B cells [33, ...B cells co-cultured with MSCs, Bafetinib significantly decreased CCR7 expression, involved in ...
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Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells
... the expression and transcriptional activity of HIF-1α are regulated by growth factors and cytokines through the activation of kinase pathways, such as the Ras/ERK1–2 and the PI3k/Akt pathways ...counterparts, ...
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AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival
... leukemia-initiating cells in myeloid leukemias (AML and CML), and in promotion of breast tumor invasion (44-46), FOXOs were originally considered to behave as tumor suppressors as conditional triple deletion of ...
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Epratuzumab targeting of CD22 affects adhesion molecule expression and migration of B cells in systemic lupus erythematosus
... integrin expression on CD27 negative B-cells after incuba- tion with epratuzumab, and the known interdependence between b 1 and b 7 integrin expression on human T-cells which share the a 4 ...
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CD22 Antigen Is Broadly Expressed on Lung Cancer Cells and Is a Target for Antibody-Based Therapy
... CD22 Antigen Is Broadly Expressed on Lung Cancer Cells and Is a Target for Antibody-Based Therapy.. Joseph M.[r] ...
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Ectopic expression of a novel CD22 splice-variant regulates survival and proliferation in malignant T cells from cutaneous T cell lymphoma (CTCL) patients
... siRNA-mediated CD22 silencing results in a profound inhibition of the survival and proliferation in malignant T cell lines further supports the notion, that CD22 exerts a functional role in the pathogenesis ...
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A novel anti-CD22 scFv–apoptin fusion protein induces apoptosis in malignant B-cells
... Abstract CD22 marker is a highly internalizing antigen which is located on the surface of B-cells and is being used as a promis- ing target for treatment of B cell ...targeting CD22 have been ...
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2 Year ( ) CLL/SLL Research Initiative CLL/SLL Collaborative Grant
... ELIGIBILITY: All principal investigators holding an academic faculty appointment, at non‐profit organizations, or public or private institutions such as universities, colleges, hospitals, and laboratories, may apply for ...
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