CD8+ CTL
IL 12 in conjunction with dendritic cells enhances antiviral CD8+ CTL responses in vitro
... cell CTL function and IFN g produc- tion (18), but were not evaluated together because of the ob- served background activity of ...augment CTL responses including antiinfluenza CTL re- sponses (32), ...
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Human Memory Cytotoxic T-Lymphocyte (CTL) Responses to Hantaan Virus Infection: Identification of Virus-Specific and Cross-Reactive CD8+ CTL Epitopes on Nucleocapsid Protein
... The CTL lines that recognize the C-terminal nine amino acids of the nucleocapsid protein (421 to 429: ISNQEPLKL) are restricted by HLA A1 and are cross-reactive against several different hantavirus ...by ...
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Cytolytic T-lymphocyte responses to respiratory syncytial virus: effector cell phenotype and target proteins.
... The RS virus target protein specificity of CD8+ CTL derived after one or two stimulations in vitro was investigated in A20-1.11 cells infected with recombinant vaccinia viruses expressin[r] ...
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CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.
... In addition, we have shown that CD4+ T cells are not necessary for the induction of a primary LCMV-specific CD8+ CTL response in vivo and that CD4-depleted mice can effectively control a[r] ...
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An orally active immune adjuvant prepared from cones of Pinus sylvestris, enhances the proliferative phase of a primary T cell response
... antigen-specific CD8 + CTL activated during a secondary T cell response is very likely due to its ability to significantly enhance the expan- sion of these cells during the early phase of the primary T cell ...
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Ontogeny and Specificities of Mucosal and Blood Human Immunodeficiency Virus Type 1-Specific CD8+ Cytotoxic T Lymphocytes
... 1-specific CTL occurs and how effectors track back to the mucosal ...cosal CTL induced by HIV-1 infection are probably primed in the mucosa-associated lymphoid tissues (MALT) and regional nodes rather than ...
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Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes.
... Infection of CD8+ CTL with HVS led to the outgrowth of a population of cells that were maintained in medium containing IL-2 10 U/ml with viability of 85 to 95%, whereas CD8+ CTL not infe[r] ...
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Human cytomegalovirus-infected cells have unstable assembly of major histocompatibility complex class I complexes and are resistant to lysis by cytotoxic T lymphocytes.
... In order to determine whether low levels of surface MHC-I in cells infected with HCMV had consequences for the recognition of the infected cell by CD8+ CTL, we examined the ability of HL[r] ...
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Contrasting Roles of the PD-1 Signaling Pathway in Dendritic Cell-Mediated Induction and Regulation of HIV-1-Specific Effector T Cell Functions
... HIV-1-specific CD8 ⫹ T ...HIV-1-specific CD8 ⫹ T cells in vitro (18, 19) and in vivo in the nonhuman primate simian immunodeficiency virus model ...on CTL function when implemented during primary versus ...
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Loss of tapasin correlates with diminished CD8+ T cell immunity and prognosis in colorectal cancer
... The association of protein markers with clinicopathologi- cal features was analyzed by receiver operating charac- teristic (ROC) curve analysis and logistic regression. The p values, odds ratios (OR) and 95 % CI for each ...
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Identification of Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Specific Cytotoxic T-Lymphocyte Epitopes and Evaluation of Reconstitution of KSHV-Specific Responses in Human Immunodeficiency Virus Type 1-Infected Patients Receiving Highly Active Antiretroviral Therapy
... further with prolonged antiretroviral therapy. The increased number of IFN-␥-releasing cells and the wide variation in individual responses, as shown by wide SE bars for cohort A, may be a reflection of the amount of ...
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Cytotoxic and proliferative T cell responses in HIV 1 infected Macaca nemestrina
... Macaca nemestrina has been described as an animal model for acute HIV-1 infection. This animal, unlike most infected humans, appears to contain HIV-1 replication. Therefore analysis of HIV-1-specific proliferative and ...
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Highlights of the society for immunotherapy of cancer (SITC) 27th annual meeting
... Data from Pawel Kalinski, Hideho Okada and col- leagues (University of Pittsburgh, Pittsburgh, PA, USA) showed that DCs maturing in different conditions in- duce different forms of immune responses. Data from Kalinski ...
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Identification and manipulation of tumor associated macrophages in human cancers
... IFNg-producing CD8+ T cells and CD40-L+ CD4 T cells allows APC to produce IL-12 and to become strong promoters of Th1 responses ...human CD8+ T cells expresses CD40-L upon activation ...tumoral CD8 T ...
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Self adjuvanting nanoemulsion targeting dendritic cell receptor Clec9A enables antigen specific immunotherapy
... date vaccine approaches to enhance immunity toward tumor neo- epitopes — long polypeptides with adjuvant and stimulatory tumor RNA lipoplexes — demonstrated safety, feasibility, and immuno- genicity of neoepitope ...
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Cross priming of cyclin B1, MUC 1 and survivin specific CD8+T cells by dendritic cells loaded with killed allogeneic breast cancer cells
... B1 could be detected after priming and two rounds of boosting with DCs loaded with killed breast cancer cells. However, this strategy did not permit detection of MUC-1 spe- cific T cells, which required an additional ...
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Cognate CD4 T-Cell Licensing of Dendritic Cells Heralds Anti-Cytomegalovirus CD8 T-Cell Immunity after Human Allogeneic Umbilical Cord Blood Transplantation
... for CTL stimulation by intracellular cytokine staining after 4 hours of coculture in the presence of ...for CTL activation (Fig. 6C). We found increased CD8 ⫹ T-cell stim- ulation in an IFN- ␥ ...
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Pathophysiology of cutaneous lupus erythematosus
... Abbreviations ACLE: Acute cutaneous lupus erythematosus; CLE: Cutaneous lupus erythematosus; CTL: Cytotoxic CD8+ T cell; DEJ: Dermoepidermal junction; DLE: Discoid lupus erythematosus; E[r] ...
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Dengue virus protein recognition by virus-specific murine CD8+ cytotoxic T lymphocytes.
... We studied the recognition by murine dengue virus-specific major histocompatibility complex class I-restricted, CD8+ cytotoxic T lymphocytes CTL of dengue virus proteins using recombinan[r] ...
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The Level of Viral Antigen Presented by Hepatocytes Influences CD8 T-Cell Function
... tested CD8 T-cell responses to peptide-pulsed HepG2 cells exposed to IFN- ␥ for 24 h prior to peptide ...between CD8 T-cell degranulation and IFN- ␥ ...the CD8 T-cell response towards ...
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