CD95/APO-1/Fas
Screening of Single Nucleotide Polymorphism in CD95 (APO 1/FAS) Promoter Region (G 1377A) in Children with Acute Leukemia
... The CD95 (Apo-1/Fas) receptor-ligand system is one of the key regulators of apoptosis and is particularly important for the maintenance of lymphocyte ho- ...The CD95 receptor (also ...
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Expression of Fas (CD95/APO-1) Ligand by Human Breast Cancers: Significance for Tumor Immune Privilege
... prognosis. Fas ligand (FasL) induces apoptotic death of activated lymphocytes that express its cell surface receptor, FasR ...kill Fas-sensitive lymphoid cells in vitro and has been associated with ...
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The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo 1) mutations
... receptor CD95 (Fas/Apo-1) are associated with defective lymphocyte apoptosis and a clinical disease characterized by lymphadenopathy, splenomegaly, and systemic autoim- ...defective ...
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Involvement of the CD95 (APO 1/Fas) receptor and ligand system in Helicobacter pylori induced gastric epithelial apoptosis
... In situ hybridization of CD95L mRNA in gastric biopsies Paraformaldehyde-fixed cryosections were dehydrated through an ascending series of ethanol and air dried. Digoxigenin-labeled anti- sense RNA corresponding to the ...
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Drug induced apoptosis in hepatoma cells is mediated by the CD95 (APO 1/Fas) receptor/ligand system and involves activation of wild type p53
... the CD95 receptor after cytotoxic ...towards CD95 mediated apopto- ...induce CD95 expression. Stimulation of CD95 expression by p53 was shown to be de- pendent on transcriptional activity ...
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Regression of basal cell carcinoma by intralesional interferon alpha treatment is mediated by CD95 (Apo 1/Fas) CD95 ligand induced suicide
... CD4 1 and CD8 1 T cell subsets can express cytolytic ac- tivity against a variety of target cells, including tumor cells, by inducing apoptosis ...CD4 1 cytotoxic T cells are capable of induc- ing ...
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Amelioration of collagen induced arthritis by CD95 (Apo 1/Fas) ligand gene transfer
... factor Fas/Apo-1 and its ligand (FasL) play pivotal roles in maintaining self-tolerance and immune ...privilege. Fas is ex- pressed constitutively in most tissues, and is dramatically ...
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Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation.
... presence or absence of an agonistic anti-Fas IgM antibody. Apoptosis of B-CLL cells was quantified by morphologic criteria (Figure 4). Spontaneous apoptosis at 24 hours ranged from less than 0.5% to 39%. Different ...
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Looking beneath the Surface: The Cell Death Pathway of Fas/APO-1 (CD95)
... (1994a) Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor. Darnay BG, Singh S, Chaturvedi MM, Ag-[r] ...
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Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes A potential role for the acidic sphingomyelinase pathway in normal immunoregulation
... of Fas (CD95 / APO-1), a cell surface receptor directly responsible for triggering cell death by apoptosis, was investigated on human T lympho- cytes resident within the intestinal lamina ...
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TRAIL receptor–mediated JNK activation and Bim phosphorylation critically regulate Fas mediated liver damage and lethality
... in Fas-induced (CD95/Apo-1–induced) hepatocyte apoptosis and liver ...amplified Fas-induced cell ...anti- Fas–induced hepatocyte apoptosis through the activation of JNK and its ...
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Inhibition of Tumor Necrosis Factor Alpha by an Adenovirus-Encoded Soluble Fusion Protein Extends Transgene Expression in the Liver and Lung
... or Fas (APO-1, CD95) have prolonged expression of an Ad transgene expressing a foreign protein in the ...or Fas would have the same effect in normal mice, we created transgenes that ...
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An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis
... The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor ...Both Fas and Fas ligand (FasL) are ...
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VEINCTR-N, an Immunogenic Epitope of Fas (CD95/Apo-I), and Soluble Fas Enhance T-cell Apoptosis in vitro. II. Functional Analysis and Possible Implications in HIV-1 Disease
... of Fas during the chronic immune activation ob- served in both HIV-1 infection and other diseases, including some autoimmune disor- ...of Fas secreted by transfected COS cells (51), their inhibition ...
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Immunogenicity of an Eight Amino Acid Domain Shared by Fas (CD95/Apo-I) and HIV-1 gp120. I. Structural and Antigenic Analysis
... both Fas and gp120 to determine whether the linear epitopes were accessible to humoral aspects of the immune ...the Fas region investigated in the present study is not described in the recent ...
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Molecular Basis of Cytotoxicity of Epstein-Barr Virus (EBV) Latent Membrane Protein 1 (LMP1) in EBV Latency III B Cells: LMP1 Induces Type II Ligand-Independent Autoactivation of CD95/Fas with Caspase 8-Mediated Apoptosis
... to Fas overexpres- sion in LCLs (11, 37, ...that Fas ex- pression parallels LMP1 expression ...for Fas-PE and HeNe laser at 633 nm for LMP1-AlexaFluor 633) avoided emission spectrum overlap between ...
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Molecular Docking of 4 Tert buthyl bis (2,6 thiomorpholin 4 ylmethyl) 1 phenol (LQM319) on Fas Receptor (CD95)
... [22] V. Dzau, A. J. Folkes, K. Ahmadi, W. K. Alderton, S. Alix, S. J. Baker, G. Box, I. S. Chuckowree, P. A. Clarke, P. Depledge, S. A. Eccles, L. S. Friedman, A. Hayes, T. C. Hancox, A. Kugendradas, L. Lensun, P. Moore, ...
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Fas/CD95 Induced Chemokines Can Serve as "Find Me" Signals for Apoptotic Cells
... apoptosis, Fas receptor stimulation can also result in the concurrent production of diverse proinflammatory cyto- kines and ...observed Fas- dependent production of cytokines and chemokines during apoptosis ...
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Houttuynia cordata Thunb extract modulates G0/G1 arrest and Fas/CD95-mediated death receptor apoptotic cell death in human lung cancer A549 cells
... by cyclins leads to phosphorylation of the retinoblastoma protein (pRb) [49] and leads to diminished binding of pRb to the E2F transcription factor, which various genes neces- sary for cell cycle progression. The ...
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The high affinity IgE receptor (FcεRI) blocks apoptosis in normal human monocytes
... exhibit a similar function, whereas the Bcl-xS isoform has the opposite effect (26–28). In transgenic mice expressing human Bcl-2 in monocytes, these do not undergo apoptosis in the absence of serum and M-CSF (2). Thus, ...
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