Cd95 ligand
CD95 ligand (FasL) induced apoptosis is necessary for corneal allograft survival
... tissue-associated CD95 ligand (Fas ligand, FasL) is an important ...Fas ligand and immune privilege has been implicated in the success of these transplants, we examined the role of FasL in ...
8
Distinct intracellular signaling in Tumor Necrosis Factor-related Apoptosis-inducing Ligand- and CD95 Ligand-mediated apoptosis
... to CD95 ligand (CD95L), TRAIL signaling requires ligand-receptor in- teraction; the downstream signaling molecules, such as Fas-associated death domain and caspase-8, also seem ...
8
Regression of basal cell carcinoma by intralesional interferon alpha treatment is mediated by CD95 (Apo 1/Fas) CD95 ligand induced suicide
... express CD95 ligand, but not the recep- tor, which may allow tumor expansion by averting the at- tack of activated CD95 receptor–positive lymphoid effector ...The CD95 ligand of BCC ...
7
Vitamin E inhibits CD95 ligand expression and protects T cells from activation induced cell death
... However, CD95-deficient cells were found to die by TCR-induced apoptosis, which could be inhibited by TNF antagonists (46, ...of CD95, TNF, or TRAIL/APO-2L (TNF-related apoptosis-inducing lig- and) ...
11
CD95 induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen activated protein kinase
... of CD95 and CD95L by OA ...of CD95 expression in normal (bottom panels) and OA cartilage (top ...CD95L, CD95 ligand; DMSO, dimethyl sulfoxide; mAb, monoclonal antibody; OA, osteoarthritis; PI, ...
10
T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions.
... Fas ligand (CD95 and CD95L) interactions can mediate this process (1, 2, 4, 8, 11, 22, 23, 27, ...Although CD95 is weakly expressed on resting T cells, its level of expression increases 10-fold on ...
5
Drug induced apoptosis in hepatoma cells is mediated by the CD95 (APO 1/Fas) receptor/ligand system and involves activation of wild type p53
... 0.25% acetic anhydride in 0.1 M triethanolamine, pH 8.0 the cells were dehydrated through an ascending series of ethanol and air dried. Digoxygenin labeled anti-sense RNA corresponding to the se- quence coding for amino ...
12
Screening of Single Nucleotide Polymorphism in CD95 (APO 1/FAS) Promoter Region (G 1377A) in Children with Acute Leukemia
... The CD95 (Apo-1/Fas) receptor-ligand system is one of the key regulators of apoptosis and is particularly important for the maintenance of lymphocyte ho- ...The CD95 receptor (also termed Apo-1 or ...
7
Involvement of the CD95 (APO 1/Fas) receptor and ligand system in Helicobacter pylori induced gastric epithelial apoptosis
... of CD95-mediated apoptosis was investigated in a panel of gastric biopsies obtained from patients with H ...increased CD95 receptor expression in epithelial and lamina propria cells in chronic ...ization, ...
10
Pro- and anti-apoptotic CD95 signaling in T cells
... member CD95 (Fas, APO-1, TNFRSF6) is known as the prototypic death receptor in and outside the immune ...by CD95 ligation in activated T cells or other “CD95-sensitive” cell ...inducible CD95 ...
9
The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo 1) mutations
... receptor CD95 (Fas/Apo-1) are associated with defective lymphocyte apoptosis and a clinical disease characterized by lymphadenopathy, splenomegaly, and systemic autoim- ...defective CD95-mediated apoptosis. ...
10
Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95 and DNA damage–induced apoptosis
... Whether Cer plays a role in apoptosis signaling should be established by experiments in which the Cer response is selectively abrogated and effects on apoptosis-induc- tion are examined. Using aSMase-deficient ...
9
Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes A potential role for the acidic sphingomyelinase pathway in normal immunoregulation
... The expression and function of Fas (CD95 / APO-1), a cell surface receptor directly responsible for triggering cell death by apoptosis, was investigated on human T lympho- cytes resident within the intestinal ...
8
Synthesis and Characterization of Some Metal Complexes with their Sulfamethoxazoleand 4,4'-dimethyl-2,2'-bipyridyl and study Cytotoxic Effect on Hep-2 Cell Line Mahasin F. Alias|Maysoon M. AbdulHassan
... The ligand 4-amino-N-(5-methylisoxazole-3-yl)-benzene-sulfonamide(L1) (as a chelating ligand) was treated with Pd(II),Pt (IV) and Au(III) ions in alcoholic medium in order to prepare a series of new metal ...
13
TRAIL receptor–mediated JNK activation and Bim phosphorylation critically regulate Fas mediated liver damage and lethality
... TNF-related apoptosis–inducing ligand (TRAIL) is a member of the TNF family with potent apoptosis-inducing properties in tumor cells. In particular, TRAIL strongly synergizes with conventional chemotherapeutic ...
8
Natural killer type 2 bias in remission of multiple sclerosis
... Flow fluorocytometry. To evaluate the surface expres- sion of CD3, CD56, and CD95, PBMCs were stained with fluorescence- or biotin-labeled antibodies reactive to each molecule. To detect intracellular cytokines, ...
8
Looking beneath the Surface: The Cell Death Pathway of Fas/APO-1 (CD95)
... (1994a) Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor necrosis factor receptor. Darnay BG, Singh S, Chaturvedi MM, Ag-[r] ...
14
Mycoplasma alligatoris Infection Promotes CD95 (FasR) Expression and Apoptosis of Primary Cardiac Fibroblasts
... glycosylated CD95 with two different antibodies against synthetic peptides mapping at the N terminus and at the C terminus of mammalian CD95 was strong evidence of the specificity of the ...putative ...
8
A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia
... of Fas signalling, since the mutation is leaky. 12 13 We also compared results in these mice with the effect of FasL neutral- isation with DcR3-a. DcR3-a is an analogue of DcR3 (TNFRSF6B) which neutralises FasL but also ...
8
unsym fac (exo OH) [Co(dien)(dapo)(N3)][ZnCl4]
... and at longer times (1–2 h, pH 9), significant production of unsym( fac ) isomers occurs. The title complex, (I), was obtained by anation with azide ion and was isolated using a combination of ion-exchange chromatography ...
8