CDKN2A/B
Carotid Artery Atherosclerosis: A Review on Heritability and Genetics
... CDKN2A/B polymorphism was strongly associated with carotid plaque score (Pott et al., 2017 ), but not with CIMT in a large-scale, multi-ethnic candidate gene association study conducted [r] ...
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Mapping of deletion breakpoints at the CDKN2A locus in melanoma: detection of MTAP-ANRIL fusion transcripts
... the CDKN2A gene , a feature common to many cancer types involves point mutations, promoter methylation or deletions at the locus [ 13 – 21 ...targeting CDKN2A/B genes constitute the predominant ...
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Original Article Association between RTEL1 polymorphisms and glioma susceptibility
... RTEL1 polymorphisms and glioma susceptibility TERT, CCDC26, CDKN2A/B, PHLDB1 and RTEL1 and the other one proved that three polymorphisms located in CDKN2B and RTEL1, two of which rs14282[r] ...
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Germline CDKN2A/P16INK4A mutations contribute to genetic determinism of sarcoma
... discussions: Sebastien Forget, Nabila Bouatia-Naji, Soto Romuald Kiando, Corine Bertolotto, Alicia Goldstein, Peter Kanetsky and Céline Lefebvre. The authors are grateful to Dr Stéphanie Baert- Desurmont, Dr Aurore ...
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Taspase1 dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription
... was hypoplasia of the prosencephalon starting at E9.5 (Figure 2, A and B). The prosencephalon serves as a signaling center and a structural support that is critical for the development of craniofa cial tissues. ...
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Global DNA methylation changes and differential gene expression in Anaplasma phagocytophilum-infected human neutrophils
... of CDKN2A, a cyclin-dependent kinase inhibitor and tumor suppressor gene, leading to increased proliferation of the urothelium ...zone B-cell lymphoma (EMZL) tumors from patients with Chlamy- dophila ...
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TALE mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts
... DNA methylation of the p16 (CDKN2A) locus results in increased replication in primary human cells. Our goal in decreasing p16 expression was to more readily permit entry into the cell cycle. Therefore, we next ...
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Risk of multiple pancreatic cancers in CDKN2A-p16-Leiden mutation carriers
... FIGURE 3 | ALK1Fc increases hypoxia and apoptosis and decreases cell proliferation in vivo. (A) Left panels: Representative images of hypoxia immunofluorescence staining (red) in primary prostate tumor samples after 5 ...
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<p>Is there a CDKN2A-centric network in pancreatic ductal adenocarcinoma?</p>
... of CDKN2A and an inhibitor of the cyclin-dependent kinase family (CDK), whose amount increases during the aging process of many tissues including ...of CDKN2A isolates CDK4/6 and prevents its binding to ...
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Collecting duct carcinoma of the kidney is associated with CDKN2A deletion and SLC family gene up-regulation
... significant role in the tumor microenvironment [29] and limiting of intracellular proline inhibits proliferation of renal cancer cells [47] . In accordance, our RNA sequence data showed the up-regulation of SLC7A11 ...
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Comparison of the inhibitory effects of three transcriptional variants of CDKN2A in human lung cancer cell line A549
... Figure 3 Cell growth inhibition and cell cycle redistribution analyses of stably transfected A549 cells. a. Cell growth curve analysis in one rep- resentative experiment. Data shown are the mean ± standard deviation of ...
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Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing
... series, CDKN2A methylation positivity corre- lated with more frequent right-sided disease, mucinous histology, tumor grade as well as with MSI, BRAF muta- tion and with KRAS mutation in the MSI setting ...with ...
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Genetic Aberrations In Childhood Acute Lymphoblastic Leukaemia (All): Application Of High-Density Single Nucleotide Polymorphism Array (SNPA)
... both CDKN2A and CDKN2B as functional candidates ...gene CDKN2A in childhood ALL (67). They discovered that CDKN2A deletion is a significant secondary abnormality in childhood ALL, which strongly ...
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The association between methylated <em>CDKN2A</em> and cervical carcinogenesis, and its diagnostic value in cervical cancer: a meta-analysis
... model was applied to calculate the association of methylated CDKN2A with cervical cancer. Our results indicated that the frequency of methylated CDKN2A in cervical cancers was significantly higher than in ...
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Constitutional mutation in CDKN2A is associated with long term survivorship in multiple myeloma: a case report.
... The case we report is striking in that after only mel- phalan therapy the patient has had a remission from MM of over 30 years and in essence is cured. Although speculative the observation is consistent with the ...
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CDKN2A CDK4 and MDM2 genes, and no significant mutations in TP53 RB1 , and CDKN2A genes in 1 case of NF
... of CDKN2A gene and an inhibitor of cyclin-dependent kinase 4 (CDK4) as well as one of the hallmarks of cellular ...of CDKN2A, CDK4 and MDM2 genes, and no significant mutations in TP53, RB1, and ...
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High Growth Rate of Pancreatic Ductal Adenocarcinoma in CDKN2A-p16-Leiden Mutation Carriers
... The current study has several strengths. Firstly, two particularly robust aspects of the study were the prospective design and the long duration of follow-up. Secondly, the study group is the largest homogeneous group of ...
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Different prognostic effect of CpG island methylation according to sex in colorectal cancer patients treated with adjuvant FOLFOX
... and CDKN2A (p16) has dele- terious effect in terms of OS and ...and CDKN2A was different among sex; it was a negative prognostic factor in men but not in women (interaction p value of ...
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CDKN2B methylation is associated with carotid artery calcification in ischemic stroke patients
... inhibitors, CDKN2A and CDKN2B, both of which involve in cell cycle regulation ...and CDKN2A/2B may suggest their functional associa- tions, which have been evidenced by results from recent studies [10, ...
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Oncogenes and tumor suppressor genes in squamous cell carcinoma of the tongue in young patients
... for Oncogenes and Tumor Suppressor (CDK4, CDKN2A, TP53, MDM2, AKT1, PIK3CA, NRAS, HRAS, KRAS, HGF, MET, EGF, ATM, BRCA1, E2F1, FHIT, RUNX3, STK11, BCL2, and CTNNB1) (Qiagen). Gene-specific PCR products were ...
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