Cell Anergy
Original Article DGKα DNA vaccine relieves airway allergic inflammation in asthma model possibly via induction of T cell anergy
... Both diacylglycerol (DAG) and phosphatidic acid (PA) are important second messengers involved in signaling transduction from many immune cell receptors and can be generated and metabolized through multiple ...
8
Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft versus host disease
... the cell culture (Figure 5d). Although IL-2 appears to reverse T cell anergy in var- ious T cell culture systems, its effect in the regulation of T cell anergy in vivo is yet to ...
10
Glycolipid antigen induces long term natural killer T cell anergy in mice
... NKT cell population in response to glycolipid activation remain poorly ...NKT cell unresponsiveness in ...NKT cell anergy was induced in a thymus-independent manner and maintained in an NKT ...
13
Cytokine therapy reverses NK cell anergy in MHC deficient tumors
... NK cell tolerance to MHC class I–deficient ...NK cell–activating ligands, but also on the inflammatory context accompanying the ...NK cell response, whereas the rel- atively noninflammatory ...
15
Epstein-Barr Virus LMP2A Alters In Vivo and In Vitro Models of B-Cell Anergy, but Not Deletion, in Response to Autoantigen
... resuspended in lysis buffer (Active Motif, Carlsbad, CA) and incubated on ice on a shaking platform. The mixture was centrifuged for 10 min at 13,000 ⫻ g at 4°C, and the supernatant containing the nuclear cell ...
8
The PPARα pathway in Vγ9Vδ2 T cell anergy
... T cell lineage in humans and non-human primates [7, 8, ...T cell response to BrHPP [7, ...T cell transcriptomes from the four macaques at the same time points are referred below to as resting, I1, I2 ...
10
Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL 4 dependent mechanism
... Th2 cell lineage and exacerbates the dis- ...Th2 cell responses in an autoimmune environment (32, ...T cell clonal expansion in vivo, presumably by activating CD28 signaling and augmenting IL-2 and ...
12
T cells presenting viral antigens or autoantigens induce cytotoxic T cell anergy
... the cell presenting CDR2 has a profound effect on effector CTL responses; the threshold for breaking tolerance to CDR2 is higher when it is expressed in T cells than in the ...
13
Signaling through CD28 and CTLA 4 controls two distinct forms of T cell anergy
... and cell sorting. Cell-surface marker staining and flow cytometric analysis were performed on a FACSCalibur flow cytometer using CellQuest soft- ware (both, Becton Dickinson and ...
10
CD8<sup>+</sup> memory T-cell inflation renders compromised CD4<sup>+</sup> T-cell-dependent CD8<sup>+</sup> T-cell immunity via naïve T-cell anergy
... To examine survival of transferred Ova-specific ConA-T cells in irradiated B6 mice, mouse peripheral blood samples were stained with PE-Ova tetramer and FITC-CD8 Ab at days 7, 14, 30, 90 after T-cell transfer. For ...
11
Intrinsic mechanisms of regulation of anti-Sm B cell anergy
... T cell tolerance mechanisms leading to autoantibody production 35, 36, 37, 38, 39 ...B cell activation in ...from cell death and to activate the PC transcriptional program, thereby preventing ...
163
Dysregulation of Circular Antigen Specific T Cells Anergy in Autoimmune Vitiligo
... T cell anergy status regarding melanocyte-specific antigen by focusing on the impaired equivalence of peripheral melano- cyte-specific cytotoxic T cells and functional Tregs in patients with progressive ...
7
Clonal anergy of CD117+chB6+ B cell progenitors induced by avian leukosis virus subgroup J is associated with immunological tolerance
... B cell anergy ...B cell anergy induced by hepatitis B virus (HBV) and human immunodeficiency virus (HIV) can cause immunological tolerance, especially in the context of congenital infection ...
13
T-Cell Receptor-Mediated Anergy of a Human Immunodeficiency Virus (HIV) gp120-Specific CD4+ Cytotoxic T-Cell Clone, Induced by a Natural HIV Type 1 Variant Peptide
... T-cell anergy, with heteroclitic peptides reverted the anergic phenotype of the T cells ...T-cell anergy may not be irreversible and that superinduction of the TCR ex- pressed by anergic ...
10
Genomics of rare genetic diseases—experiences from India
... B cell expansion with NF- κ B and T cell anergy; CFC: Clotting factor concentrates; CME: Continuing medical education; COL17A1: Collagen type XVII α 1; CSIR: Council of Scientific and Industrial ...
18
Epitope specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL 2 and IL 15 in vitro
... T cell epitopes, which are recognized by both allergic and non-allergic bee venom sensitized ...T cell and cytokine re- sponses in PBMC of bee sting allergic patients were investi- gated before and after 2 ...
9
Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen induced anergy
... of anergy-related genes in RA and ReA synovial ...of anergy, but peptide- induced anergy provides two significant ...other anergy models, calcium-signaling path- ways may be defective in ...
11
Immune function of successfully treated lymphoma patients
... dinitrochlorobenzene or keyhole limpet hemocyanin. Four other patients developed reactivity to only one of these neoantigens for a total of 14 of 16 (88%) of the patients demonstrating some impairment in neoantigen ...
11
Energy = Exergy + Anergy
... The Second Law of Thermodynamics is related to useful and useless energy .So ,there are two components for energy. The component of energy that can be harnessed to do some work is called exergy(foreground pixels in ...
5
Activation and inhibition of lymphocytes by costimulation
... of cell surface molecules on the responder lymphocyte and an “accessory” cell — an antigen-presenting cell (APC) in the case of T cell activation, or a helper T cell for B cell ...
6