cell-based cartilage repair
Major biological obstacles for persistent cell based regeneration of articular cartilage
... [179,182-184]. Cell-based cartilage repair in OA knees has been attempted, with equal results compared to cartilage repair procedures in non- arthritic knees ...of ...
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A novel arthroscopic technique for intraoperative mobilisation of synovial mesenchymal stem cells
... One of the concerns of stem cell–based cartilage repair is cartilage hypertrophy, which leads to uneven articular sur- face. Synovium-derived MSCs exhibit superior chondrogenic capacity ...
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Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytes
... for cell-based cartilage repair ...for cartilage therapy development ...for cartilage tissue engineering applications [6, ...and cartilage extracellular matrix [35-37] by ...
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Autologous, allogeneic, induced pluripotent stem cell or a combination stem cell therapy? Where are we headed in cartilage repair and why: a concise review
... 1 Cell-based therapies for cartilage defects have evolved through a few generations with various cell ...one cell type can be used, but the cell expansion can take several ...
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Articular cartilage repair and the evolving role of regenerative medicine
... articular cartilage repair has now been used for 2 decades and forms a successful example of translational ...medicine. Cartilage is characterized by a limited intrinsic repair capacity ...
14
Optimization and Translation of MSC-Based Hyaluronic Acid Hydrogels for Cartilage Repair
... numerous cell types and supports chondrocyte- mediated ECM deposition (Kisiday et ...promote cell adhesion and neurite extension (Holmes et ...mesenchymal cell condensation, and is a primary ...
211
Pericellular collagen I coating for enhanced homing and chondrogenic differentiation of mesenchymal stem cells in direct intra-articular injection
... [2]. Based on this property, these cells may be trans- planted into a cartilage defect by a simple and mini-invasive ...in cartilage repair [3, ...Stem cell therapies rely on the ...
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Scaffold-free tissue engineering for injured joint surface restoration
... of cell-based technologies, many of the recent tissue engineering approaches have taken advantage of scaffolds made of either synthetic (Vunjak-Novakovic et ...into cartilage defects (Bright and ...
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Translational applications of photopolymerizable hydrogels for cartilage repair
... Stem cell-based therapy is an attractive approach to en- hance cartilage repair, especially when applying MSCs that exhibit a reliable potential for chondrogenic differ- ...knee ...
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Reprogramming of blood cells into induced pluripotent stem cells as a new cell source for cartilage repair
... to cell-based therapeutic applications, iPSC technology could also provide patient- specific cells and tissue models for tissue repair ...current cell harvest ...
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Ongoing studies of cell-based therapies for articular cartilage defects in Japan
... Recently, cell-based therapies have generated great interest in the repair of articu- lar cartilage defects and ...a cell scaffold and other devices. Meanwhile, advanced ...
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1. Study of chondrogenesis in murine mesenchymal stem cells as a cell therapy in cartilage repair by in silico approach
... Bio interpreter is a simple, user-friendly web-based biological interpretation tool for Microarray data analysis. It significantly reduces the biological analysis time from weeks to hours. Simple, quick and ...
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Engineered Fibrous Hyaluronic Acid Hydrogels for Cartilage Repair
... the cell suspension onto the fibrous sample and subsequent overnight ...of cell spreading, proliferation, and focal adhesion formation, hMSCs were seeded onto the scaffolds at a density of 15, 20, or 25 ...
190
Alginate-based hydrogels functionalised at the nanoscale using layer-by-layer assembly for potential cartilage repair
... for cartilage regeneration for their distinctive biocompatibility, ability to include chemical biocues, and intrinsic hydrated structure [4, ...for cell supporting. Natural-based polymers represent a ...
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Role of cartilage-forming cells in regenerative medicine for cartilage repair
... articular cartilage repair are successful in stimulating regrowth of damaged ...cases, repair may not be possible, and regeneration may be the only method for healing a defect and providing the ...
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Evaluation of a biopolymer matrix for cell based bone repair
... have the capacity to divide and form two equal daughter cells and differentiate into tissue-specific cells on stimulation by signaling molecules (Elisseeff J, 2005). These multipotent cells can proliferate and ...
85
Operative Treatment of Knee Cartilage Injuries: A Review of the Current Literature on Non-Cell-Based and Cell-Based Therapies
... articular cartilage damage in the knee has developed considerably over the past few decades but debate persists about the best form of ...in cartilage repair are testament to the challenging problem ...
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Mesenchymal stem cells for cartilage repair in osteoarthritis
... allogeneic cell-based therapies using BMSCs for cartilage repair have been shown to produce acceptable clinical ...articular cartilage in patients with OA is not clear, the ability of ...
9
Current perspectives in stem cell research for knee cartilage repair
... Strategies based on the application of stem cells that can be relatively easily acquired, expanded, and selectively committed towards a cartilaginous tissue may provide effective treatments for cartilage ...
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Treatment of focal degenerative cartilage defects with polymer based autologous chondrocyte grafts: four year clinical results
... full-thickness cartilage biopsy is taken from a less weight-bearing area of the healthy articular ...healthy cartilage rim, creating a res- ervoir for the injection of the autologous chondrocyte cell ...
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