Cell-cycle arrest
Original Article MiR-17-5p decreases cell viability by inducing cell cycle arrest in PC12 cells following oxygen and glucose deprivation
... in cell viability and the underlying mechanisms after acute oxygen and glucose deprivation ...induced cell cycle arrest at the G1-S phase. Decreased cell viability and Cyclin D1 ...
7
/M cell cycle arrest in the broiler’s kidney
... In order to define how dietary NiCl 2 induced G 2 /M cell cycle arrest in the kidney, we measured G 2 /M phase cell cycle regulatory molecules. The results showed that NiCl 2 increased ...
14
/M cell cycle arrest induced by AFB
... /M cell cycle arrest in jejunum through p53-dependent p21 .../M cell cycle arrest by down-regulating cdc2 and PCNA ...induced cell cycle G 2 /M arrest and ...
15
Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway
... underwent cell cycle arrest and senescence upon depletion of HMGB1 ...observed cell cycle arrest and senescence as these phenotypes were rescued upon depletion the expression of ...
17
Vpr-induced cell cycle arrest is conserved among primate lentiviruses.
... species-specific cell cycle arrest differences observed in this study, it seems unlikely that Vpr and Vpx affect the cell cycle through direct interaction with the CDC2 ...
9
Apoptosis induction, cell cycle arrest and in vitro anticancer activity of gonothalamin in a cancer cell lines
... of cell cycle is very important in the study of molecular mechanism of cell death and cell cycle progression (Tao et ...of cell cycle measures the apoptotic changes in ...
6
Original Article MicroRNA-25 regulates small cell lung cancer cell development and cell cycle through cyclin E2
... small cell lung cancer ...SCLC cell lines and 9 human SCLC tissues. In SCLC cell line H510A cells, endogenous miR-25 was downregulated by stable transfection of antisense oligonucleotide of miR-25 ...
9
CCAAT/Enhancer Binding Protein α Interacts with ZTA and Mediates ZTA-Induced p21CIP-1 Accumulation and G1 Cell Cycle Arrest during the Epstein-Barr Virus Lytic Cycle
... fluorescence-activated cell sorting (FACS) analysis, we compared the protein expression level of Ad-ZTA with the physiological ZTA level obtained in a lytically induced Akata cell culture with almost the ...
20
Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin
... between cell cycle regulation and cancer, and inhibition of the cell cycle has become an appreciated target for cancer management ...phase arrest in MDA-MB-231 cells. The tumor ...
11
Human Parvovirus B19 Nonstructural Protein (NS1) Induces Cell Cycle Arrest at G1 Phase
... and others have shown that NS1 expression induces cell death with apoptotic features in erythroid cells in vivo and in vitro, suggesting that NS1 is a viral apoptotic factor (7, 15, 19, 24). However, there was an ...
7
Original Article FOXO3a expression and its diagnostic value in pancreatic ductal adenocarcinoma
... inhibit cell proliferation, tumorigenesis, and cell cycle progression [30], which play an important role in tumor initiation and ...induces cell cycle arrest in pancreatic cancer ...
8
Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer
... tumor cell migration and invasion and inhibited apoptosis and cell cycle arrest in COLO205 ...tumor cell migration and invasion and induced apoptosis and cell cycle ...
13
Multi scale modelling of the dynamics of cell colonies : insights into cell adhesion forces and cancer invasion from in silico simulations
... a cell population with endocytosis rate 0.6 min 21 , cell cycle arrest occurs if the pressure in the cell is greater than 13 000 pN and a force equal to the repulsive force between ...
13
Original Article MiR-22 functions as a biomarker and regulates cell proliferation, cycle, apoptosis, migration and invasion in renal cell carcinoma
... Caki-1 cell proliferation, colony forma- tion, cell motility, migration and invasion, as well as induced cell cycle arrest and promoted apoptosis in RCC cells, while blockage of miR- 22 ...
13
Acanthamoeba induces cell cycle arrest in host cells
... HCEC were incubated alone under similar conditions. Following this incubation, cells were washed three times with PBS-Ca and RNA was isolated using an RNAqueous kit (Ambion) according to the manufac- turer’s ...
8
MERTK as a novel therapeutic target in head and neck cancer
... our cell lines UNC1062 treatment induced a cell cycle arrest in the G2 Phase due to unspecific off- target effects of this inhibitor since we observed this arrest independent of MERTK ...
17
Human Immunodeficiency Virus Type 1 Vpr Binds to the N Lobe of the Wee1 Kinase Domain and Enhances Kinase Activity for Cdc2
... induces cell cycle ...for cell cycle arrest by ...alleviates cell cycle arrest, supporting a common pathway for Vpr and Wee1 in the induction of cell ...
11
B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy
... analysis, cell lysates were prepared by incubation in RIPA buffer containing protease inhibitors cocktail (1 mM phenylmethanesulfonyl fluorideand and 1 μg/ml leupeptin) and phosphatase inhibitors cocktail (1 mM ...
18
Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations
... mutant cell lines with highest sensitivity to the combination there was evidence of a pERK decrease after exposure to ...these cell lines would be due to a more signifi- cant blockade of oncogenic MAPK ...
13
ROSMARINIC ACID ENHANCES CISPLATIN CYTOTOXICITY IN HEPG2 CELL LINE AND ATTENUATES ITS NEPHROTOXICITY IN MICE
... tumor cell line (HepG2) and human breast cancer cell line (MCF-7) were obtained frozen in liquid nitrogen from the American Type Culture Collection (ATCC, Manassas, VA, ...The cell lines were ...
13