Cell-cycle arrest at G1 phase
Human Parvovirus B19 Nonstructural Protein (NS1) Induces Cell Cycle Arrest at G1 Phase
... (ataxia telangiectasia mutated) and ATR (ATM- and Rad3- related) members of the phosphoinositide kinase family (1). The activation of ATM and ATR induces activations of their downstream protein kinases, Chk1 and Chk2, ...
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Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells
... induces cell cycle arrest at G1 phase and induce ER-stress to promote cell apoptosis, thus revealing the molecular mechanism of psoralen in anti-hepatoma effect in ...
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Tissue specific G1 phase cell cycle arrest prior to terminal differentiation in Dictyostelium
... mtDNA were based on the differences between whole-cell and nuclear flow cytometry, or by direct measurements (Durston et al., 1984; Leach and Ashworth, 1972). Our experiments suggest that mtDNA constitutes ~30% of ...
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Lycorine induces cell-cycle arrest in the G0/G1 phase in K562 cells via HDAC inhibition
... CML cell line ...the cell cycle distribution after lycorine ...G0/G1 phase arrest, which is mediated by the regulation of G1-related pro- ...
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G1 Phase Arrest and Apoptosis Induction in Human Thyroid Cancer Cell Line Thr.C1.PI33 by 3-Hydrogenkwadaphnin Isolated from Dendrostellera lessertii
... within G1, S, and G2-M phases were determined by flow cytometric (FCM) analysis; electron microscopic pictures were taken after fixation with 2% ...apoptotic cell death was confirmed by the observation of ...
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Aquaporin 9 inhibits hepatocellular carcinoma through up- regulating FOXO1 expression
... tissues, which is consistent with a previous report [14]. What we extended further is that AQP9 overexpression in a human hepatoma cell line inhibited cell growth by causing cell cycle ...
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Influenza A Virus Replication Induces Cell Cycle Arrest in G0/G1 Phase
... respective cell cycle synchronization ...(A) Cell cycle profiles before infection were determined by FACS ...each phase of the cell ...
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Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest
... glioblastomas cell of different transformation degree, especially higher expressed in U251 cells that were derived from a high-grade glioblast- oma; therefore, these phenomenon represent a reason- able cell ...
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Praeruptorin A Inhibits Cervical Cancer HeLa Cell Growth and Invasion by Suppressing MMP-2 Expression and ERK1/2 Signaling
... PA induces cell cycle arrest at G0/G1 phase in human cervical cancer HeLa cells.. 107.[r] ...
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A computational model for the coordination of neural progenitor self renewal and differentiation through Hes1 dynamics
... coordinate cell division and differentiation in space and ...and cell cycle progression and directs cell fate decisions at various developmental stages in many cell types, is central to ...
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The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction
... promoting cell cycle arrest, apoptosis, differentiation and senescence along with altered angiogenesis[30, ...31]. Cell senescence is recognized as senescent morphology as well as loss of ...
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Ascorbyl palmitate/d-α-tocopheryl polyethylene glycol 1000 succinate monoester mixed micelles for prolonged circulation and targeted delivery of compound K for antilung cancer therapy in vitro and in vivo
... A549 cell model, CK AP/TPGS mixed micelles significantly inhibited cell growth, induced G0/G1 phase cell cycle arrest, induced cell apoptosis, and inhibited ...
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Original Article Dihydroartemisinin inhibits cell proliferation via AKT/GSK3β/cyclinD1 pathway and induces apoptosis in A549 lung cancer cells
... small cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC); non small cell lung carcinoma (NSCLC) includes squamous cell carcinoma (SCC), adenocarcinoma and large cell ...
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Multi-target mode of action of a Clerodane-type diterpenoid from Polyalthia longifolia targeting African trypanosomes
... Microscopical investigation of cellular morphology of T. brucei treated with HDK20. Fluorescence microscopy after DAPI staining showed that 70% of the cell population incubated with HDK-20 (0.4 µ g/ml) contained ...
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Original Article The antitumor effects and mechanisms of the novel compound Alocasia B against gastric cancer cells
... A cell line panel with 12 gastric cancer cells was screened to determine the cytotoxic properties of Alocasia B using an MTT ...the cell cycle and apoptosis by flow ...cancer cell lines ...
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Effect of TLR2 on the proliferation of inflammation-related colorectal cancer and sporadic colorectal cancer
... mantle cell lymphoma, TLR2 promotes the proliferation of tumor cells, and it can also inhibit the cell cycle progression of mantle cell lymphoma, leading to G1 phase ...
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<p>The Natural Product Fucoidan Inhibits Proliferation and Induces Apoptosis of Human Ovarian Cancer Cells: Focus on the PI3K/Akt Signaling Pathway</p>
... the cell cycle and apoptosis? In cancer cells, activated PI3K pro- duces PIP3 on the plasma membrane, as a second messen- ger, which binds to the signaling proteins, Akt and PDK1, containing a PH domain in ...
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<em>LEF1-AS1</em>, a long non-coding RNA, promotes malignancy in glioblastoma
... reduced cell proliferation, migration, and invasion, and induced cell- cycle G1 phase arrest and apoptosis in the U87 and U251 cell ...
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Human T-Cell Leukemia Virus Type 1 Infection Leads to Arrest in the G1 Phase of the Cell Cycle
... in cell cycle ...mammalian cell lines has been difficult to ...other cell cycle ...M phase (20) and contributes to a delay in cell cycle progression, DNA aneu- ...
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Influence of Carbon Monoxide on Growth and Apoptosis of Human Umbilical Artery Smooth Muscle Cells and Vein Endothelial Cells
... muscle cell (hUASMC) and human umbilical vein endothelial cell (HuVEC) and further evaluated the growth and apoptosis status of SMC and ...blocked cell cycle progress of SMC and HuVEC, more ...
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