cell depletion
B cell depletion in autoimmune diabetes:insights from murine models
... B cell depletion in T1D in terms of promoting C peptide levels ...B cell numbers (as assessed by CD19 staining) remained effectively suppressed at 6 months post treatment (below 20% of the number in ...
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B cell depletion: a novel therapy for autoimmune diabetes?
... B cell depletion in mice, a clinical trial using the B cell–depleting anti-CD20 monoclonal antibody rituximab (Rituxan) is underway in type 1 diabetes ...B cell depletion in these mice ...
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Apoptosis and T-cell depletion during feline infectious peritonitis.
... T-cell depletion. T-cell suppression may enhance viral replication during ...that cell-mediated immunity plays a decisive role in the protection against ...suppress cell-mediated ...
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B cell depletion in autoimmune disease
... B lymphocytes arising from haematopoietic stem cells pass through a series of intermediate stages (pro-B, pre-B, immature B and mature B cells); this gives rise to plasma cells, which produce immunoglobulins. Although ...
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Induction of long term B cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity
... B-cell depletion was more pronounced than that of total IgG and, on the contrary, that serum concentrations of pro- tective antibodies against measles, mumps and rubella remained ...
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The mechanism of anti CD20–mediated B cell depletion revealed by intravital imaging
... B cell depletion through Ab-dependent cellular ...the depletion mechanism or whether KCs were simply scavenging dead cells previously killed by other effec- tors could not be directly ...B ...
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Anti-CD20 B-cell depletion enhances monocyte reactivity in neuroimmunological disorders
... whether depletion of CD20 + AQP4-specific plasma cell precursors provides the sole and entire basis for therapeutic benefit of anti- CD20 in NMO ...B-cell depletion diminished pro- liferation ...
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Mechanisms of HIV-1-mediated CD4+ T cell depletion in lymphoid tissue
... CD4+ cell depletion in lymphoid organs, full-length HIV-1 viruses were generated that expressed chimera HR-2 Envs to compare against NL4-R3A and ...CD4 depletion activity was observed with all HIV-1 ...
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Germ cell depletion from mammalian ovary: possible involvement of apoptosis and autophagy
... include cell shrinkage, nuclear condensation, membrane blebbing and cytoplasmic fragmentation by both mitochondria- as well as death receptor-mediated pathways in encircling granulosa cells and ...germ cell ...
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Satellite cell depletion prevents fiber hypertrophy in skeletal muscle
... McCarthy et al. (2011) did not report CSA averages, but from their CSA histogram we calculated that the average overload hypertrophy was ≈ 11% in SC+ muscles, and similarly so also in a more recent paper (Kirby et al., ...
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Medullary thymic epithelial cell depletion leads to autoimmune hepatitis
... T cell development and establishment of tolerance to self-antigens occurs in the thymus and depends on cross-talk between thymo- cytes and the thymic epithelium ...T cell repertoire, mTECs ectopically ...
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Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors
... Treg cell depletion, which may underlie the lack of anti-tumor activity previously observed in pre-clinical ...effective depletion of tumor-infiltrating Treg cells, increased effector to Treg ...
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PD L1 serves as a double agent in separating GVL from GVHD
... T cell depletion on GVL versus GVHD and revealed that depletion of CD4 + T cells leads to the upregulation of PD-L1 by recipient tissues and donor CD8 + T ...T cell exhaustion and apoptosis, ...
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NK cell count as predictor of clinical response in patients with rheumatoid arthritis treated with rituximab
... B cell depletion, rheumatoid factor titer in RA, or lowering titers of anti-double-stranded DNA antibodies for lupus patients and, thus, research in rituximab therapy in autoimmune diseases includes seeking ...
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The regulation of STIM1 translocation to the plasma membrane
... expression, cell growth and ...the depletion of Ca 2+ from internal Ca 2+ stores, the main store being the endoplasmic reticulum (ER), are the major route for Ca 2+ influx in non-excitable cell ...
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The regulatory roles of neutrophils in adaptive immunity
... B cell maturation and survival ...plasma cell and antibody generation associated with production of BAFF ...B cell activation, while over- expression of APRIL could induce B-cell ...B ...
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B cells do not have a major pathophysiologic role in acute ischemic stroke in mice
... To exclude that the CD20 antibody influences outcome measures independent of its B cell-depleting effect, we additionally analyzed JHD −/− mice that lack B cells (Additional file 1: Figure S1) [10]. Again, there ...
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<p>SSBP1 Upregulation In Colorectal Cancer Regulates Mitochondrial Mass</p>
... Since our dataset is limited to providing protein informa- tion on changes in CRC, we next sought to evaluate if these changes were also reproducible on a transcriptional level. We fi rst turned to the TCGA CRC dataset ...
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Convergence and extension at gastrulation require a myosin IIB dependent cortical actin network
... per cell (33 foci total) were followed for 5 minutes; for pre-involution axial mesoderm [pre-notochord (PN)] and animal cap (AC), five cells with at least 20 foci were ...each cell, except for AC cells, for ...
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Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells
... significantly elevated the percentage of cells in early apop- totic and late apoptotic stages. Western blot further sug- gested knockdown of TMPO increased the cleavage of caspase-3 and PARP expression. Caspase ...
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