cell fate specification
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin producing cell fate specification at the expense of the α and β cell lineages in the mouse endocrine pancreas
... -cell fate specification at the expense of δ -cell ...endocrine cell subtypes, as compared ...subtype specification during pancreatic ...precursor cell initially expresses ...
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Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development
... and cell fate specification during limb ...allows cell cycle withdrawal and expression of Sox9, leading to establishment of the chondrogenic core (indicated in blue, marked by ...
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Notch regulates numb: integration of conditional and autonomous cell fate specification
... Notch cell-cell signaling pathway is used extensively in cell fate specification during metazoan ...many cell lineages, the conditional role of Notch signaling is integrated with ...
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NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo
... embryonic cell fate specification in vivo, we constitutively activated the NOTCH pathway in the pre- and peri- implantation mouse embryo by using genetic ...of cell types from all three germ ...
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The HMX homeodomain protein MLS 2 regulates cleavage orientation, cell proliferation and cell fate specification in the C elegans postembryonic mesoderm
... including cell proliferation, cell fate specification and ...single cell resolution. The M lineage is derived from a single progenitor cell, the M mesoblast, which is born during ...
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p120RasGAP mediates ephrin/Eph dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos
... FGFs are secreted ligands that selectively bind to a class of receptor tyrosine kinases (RTKs), the FGF receptors (FGFRs). The prominent pathway downstream of FGFR is the Ras/MAPK cascade, whereby a GTP-bound form of Ras ...
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C elegans EVI1 proto oncogene, EGL 43, is necessary for Notch mediated cell fate specification and regulates cell invasion
... dependent cell fate specification, but also to understand how a cell fate decision is coupled to the later-stage differentiation ...of cell division (Kimble and Hirsh, 1979; ...
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The TGFβ intracellular effector Smad3 regulates neuronal differentiation and cell fate specification in the developing spinal cord
... (few cell diameters) dorsal expansion of ...V0 cell identities, were generated to occupy the MN domain ...MN specification and terminal differentiation, whereas Smad3 activity promotes the generation ...
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Differential Effects of Drosophila Mastermind on Asymmetric Cell Fate Specification and Neuroblast Formation
... unique fate by the time it is formed, and the shown that eliminating Notch activity in sensillum pre- NB that forms in a given position at a given time always cursors leads to hyperplasia of the sensory neurons at ...
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Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
... eight- cell stage (not shown), and Cdx2 protein was first clearly detected in the nucleus and cytoplasm of the outer cells of early morula (~16 cells, n=4; ...(~25 cell) ...
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Photoreceptor cell fate specification in vertebrates
... analogous to Nrl (Fig. 4D). The identity of such a factor(s) remains unknown. Third, it is possible that the combinatorial action of more widely expressed regulators (i.e. not lineage restricted to photoreceptor ...
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The Caenorhabditis elegans Excretory System: A Model for Tubulogenesis, Cell Fate Specification, and Plasticity
... pore cell (in blue) (B) forms a seamed tube by wrapping and forming an autocellular junction ...duct cell (in yellow) (C) initially forms a seamed tube and then converts to a seamless tube via autofusion to ...
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α6-Integrin alternative splicing: distinct cytoplasmic variants in stem cell fate specification and niche interaction
... stem cell marker in diverse ...stem cell stemness, regulation of stem cell differentiation, orientation of dividing stem cells, and migration and/or homing of hematopoietic stem/progenitor cells to ...
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Mammary gland development: cell fate specification, stem cells and the microenvironment
... An overview of embryonic mammary gland development In mice, embryonic mammary gland development occurs between embryonic day (E) 10.5 and E18.5 (Hens and Wysolmerski, 2005; Sakakura, 1987; Veltmaat et al., 2003). It ...
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Divergence of zebrafish and mouse lymphatic cell fate specification pathways
... lymphatic specification in zebrafish must be achieved in a different way, possibly through the broadened activity of another functionally related transcription ...
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Building a plant: cell fate specification in the early Arabidopsis embryo
... the specification of the uppermost suspensor cell, the ...This cell further divides asymmetrically to form a smaller lens-shaped cell and a larger basal cell ...the specification ...
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Sox proteins: regulators of cell fate specification and differentiation
... inner cell mass; iPSCs, induced pluripotent stem cells; Jag1, jagged 1; KO, knockout; Lefty1, left right determination factor 1; Maf1, MAF1 homologue; Mef2c, myocyte enhancer factor 2C; Mitf, ...
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PubMedCentral-PMC4915122.pdf
... Fig. 2. A systematic RNA selection mechanism. (A) Transcriptional activation by GLP-1/Notch signaling. DTCs function a GSC niche. LAG-2, a Notch ligand, is expressed on the DTC membrane. Notch receptor, GLP-1, is ...
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Maternal intake of high n 6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice
... stem cell maintenance, cell fate specification, dif- ferentiation, proliferation, motility, and survival during embryonic development and in cancers [41], our find- ings indicate that ...
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Regulation of ventral midbrain patterning by Hedgehog signaling
... for cell-fate specification within columns of midbrain cells, which are cytoplasmically connected and likely to be clonally related (Noctor et ...31 cell diameters) at Hamburger and Hamilton ...
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