Cell killing
The Cell Biology of Systemic Hyperinflammation Resulting from Failed Cytolytic Target Cell Killing
... Target cell killing in the verte- brate adaptive and innate immune responses to cancerous or infected cells is mediated by the action of cytolytic T lymphocytes (CTLs) and natural killer (NK) cells ...
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Inhibition of Amebic Lysosomal Acidification Blocks Amebic Trogocytosis and Cell Killing
... We have shown that interference with acidification does not impact the initiation of amebic trogocytosis, but rather impairs continued ingestion and cell killing. There was no difference in the abilities of ...
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Role for the Paramyxovirus Genomic Promoter in Limiting Host Cell Antiviral Responses and Cell Killing
... There are a number of cellular pattern recognition receptors other than RIG-I that recognize dsRNA to induce host cell responses, including mda-5 and protein kinase R (PKR). The Le-(U5C, A14G) mutant expresses a ...
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Apoptosis: a mechanism of cell killing by influenza A and B viruses.
... 68, 1994 MECHANISM OF CELL KILLING BY INFLUENZA A AND B VIRUSES Z 3 4 3669 5 ical marker of apoptosis 28, we first examined the abilities of Ty/Ont and PR8 to induce DNA fragmentation in[r] ...
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Photoactivated cell killing involving a low molecular weight, donor acceptor diphenylacetylene
... observable cell death ...initiate cell death upon photoactivation rather than an inherent biochemical or bio- logical signalling activity of a diphenylacetylene retinoid or retinoid-like ...activated ...
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Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene
... of Cell- Rox nor any observable cell death ...initiate cell death upon photoactivation rather than an inherent biochemical or biological signalling activity of a diphenylacety- lene retinoid or ...
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T cell killing by tolerogenic dendritic cells protects mice from allergy
... DCs comprise multiple subsets and exhibit crucial functions as activators and regulators of immune processes including tolerance induction (48, 49). Although the underlying mechanisms have not been fully elucidated, it ...
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A major mechanism of human immunodeficiency virus-induced cell killing does not involve cell fusion.
... As background information for studies on the cytopathic effects of HIV infections for T4+ lymphoid cells, we monitored HIV infections in a line of T4+ lymphoid cells which had been repor[r] ...
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Photodynamic and photothermal human cancer cell killing using gold nanoparticles
... in cell viability was ...later, cell viability was determined by counting the blue cells, missing cells and cells that had a dramatic morphological ...
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Bystander Host Cell Killing Effects of Clostridium perfringens Enterotoxin
... The cell pellets were suspended in lysis buffer {50 mM HEPES (pH ...each cell lysate (as prepared above), 10 l of caspase substrate solution, and assay buffer were com- bined in a total 100- l volume ...
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Cell killing by avian leukosis viruses.
... The cytopathic avian leukosis viruses cause characteristic changes in cells during acute infection; cells become granular, there is an increased number of rounded and floating cells, and[r] ...
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Cell killing by simian virus 40: impairment of membrane formation and function.
... Summary of time course of SV40 cytopathic effects Event Begins h Lysosomal enzyme release N-acetyl-f3-glucosaBefore 30 minidasea Mitochondrial enzyme release MDH Before 30 32-40 Cytoplas[r] ...
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Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity
... 20% cell death at the same lipid ...higher cell-killing efficacy was due to the combination of gold nanoparticle-mediated PDT and chemotherapy, we also separately assessed the ...
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Demonstration of anti-tumour bystander killing with prodrug-preloaded suicide gene-engineered tumour cells: a potential improvement for cancer therapeutics
... tumour cell killing” mecha- nisms are mediated by this method: (a) a local “direct” bystander effect, as a result of the transfer of ganciclovir triphosphate from HSV-TK-positive tumour cells into ...
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Developing Novel Oncolytic Adenoviruses through Bioselection
... tumor cell killing and virus ...cancer cell lines of diverse tissue origin tested ...mor cell selectivity of these oncolytic agents ...
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Host-Dependent Restriction of Mengovirus Replication
... Thus, the quantitative cell killing noted in all three cell lines, coupled with the comparable efficiency of infectious center formation in L-cells and MDBK, strongly suggests that all t[r] ...
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The role and clinical significance of DNA damage response and repair pathways in primary brain tumors
... in killing BRCA1-mutated (DSB-repair deficient) cells, and provide an overall survival and progression-free survival benefit with minimal toxicity in patients with BRCA1- deficient familial breast cancer ...
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Particle therapy and nanomedicine: state of art and research perspectives
... In the case of ion beam irradiation, an enhancement of radiation effects was observed in the presence of nanoparticles either at the molecular (DNA damage), in vitro (cell killing) and in vivo (mouse tumour ...
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Apoptosis Induction by the Binding of the Carboxyl Terminus of Human Immunodeficiency Virus Type 1 gp160 to Calmodulin
... T-cell killing by this ...Env-mediated cell killing of HIV infection, and they also indicate that the binding of CaM to the carboxyl terminus and subsequent apoptosis induction therefore ...
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Nanomedicine: towards development of patient-friendly drug-delivery systems for oncological applications
... endothelial cell receptors (vascular cellular adhesion molecules, vascular endothelial growth factor, etc) such as angiogenesis antagonists and monoclonal antibodies against typical tumor signatures such as ...
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