Cell-mediated cytotoxicity
In vitro cell mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis Dysfunction of spontaneous cell mediated cytotoxicity in primary biliary cirrhosis
... target cell specificity of peripheral blood lymphocytes from selected patients with primary biliary cirrhosis and hepatitis B surface antigen-negative chronic hepatitis were investigated using 51Cr-labeled human ...
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Antibody dependent cell mediated cytotoxicity in selected autoimmune diseases
... Antibody-dependent cell-mediated cytotoxicity mediated by peripheral blood lymphocytes was studied in patients with systemic lupus erythematosus, polyarteritis ...Antibody-dependent ...
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NK mediated antibody dependent cell mediated cytotoxicity in solid tumors: biological evidence and clinical perspectives
... antibody-dependent cell-mediated cytotoxicity (ADCC) and high epidermal growth factor receptor (EGFR) expression predict favourable outcome in patients with locally advanced head and neck cancer ...
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Enhancement of antibody-dependent cell mediated cytotoxicity: a new era in cancer treatment
... NK cell-mediated cytotoxicity. 62,63 Recently, Hamano et al 64 have demonstrated in a preclinical model that reovirus can augment trastuzumab-induced cytotoxicity in gastric cancer cells. ...
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Antibody-Dependent Cell-Mediated Cytotoxicity in Simian Immunodeficiency Virus-Infected Rhesus Monkeys
... antibody-dependent cell-mediated cytotoxicity (ADCC) response during acute and chronic SIVmac251 infection of rhesus ...NK cell expression of CD107a with NK cell expression of other ...
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RB mutation and RAS overexpression induce resistance to NK cell-mediated cytotoxicity in glioma cells
... a cell phenotype compatible with glioma cell evasion from NK cell-mediated ...two cell lines that survived the cytotoxic effect of mice NK cells were also analyzed and showed increased ...
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The Granzyme B ELISPOT assay: an alternative to the 51Cr release assay for monitoring cell mediated cytotoxicity
... Granzyme B is a potential candidate molecule for measur- ing tumor specific T-cell responses via the ELISPOT method. This molecule is present in CTL and NK cells and is constitutively expressed in memory but not ...
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Effector cell mediated cytotoxicity measured by intracellular Granzyme B release in HIV infected subjects
... T cell receptor will bind to the labeled tetramers and can be quantified by flow ...T cell responses, are thought to explain data correlating different HLA alleles with different rates of clinical ...
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Comparison of Antibody-Dependent Cell-Mediated Cytotoxicity and Virus Neutralization by HIV-1 Env-Specific Monoclonal Antibodies
... ABSTRACT Although antibodies to the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein have been studied extensively for their ability to block viral infectivity, little data are currently available on ...
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Identification of Dominant Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus
... Antibody-dependent cell-mediated cytotoxicity (ADCC) bridges innate and adaptive immunity, and it involves both humoral and cellular immune ...
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Interaction with Cellular CD4 Exposes HIV-1 Envelope Epitopes Targeted by Antibody-Dependent Cell-Mediated Cytotoxicity
... antibody-dependent cell- mediated cytotoxicity ...HIV-1-infected cell effectively exposes these ...Importantly, cell surface CD4 downregulation by Nef and Vpu accessory proteins and ...
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Type I IFN protects cancer cells from CD8+ T cell–mediated cytotoxicity after radiation
... was mediated by enhanced susceptibility to T cell–mediated ...T cell killing after ...T cell–mediated cytotoxicity through regulation of ...
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Comprehensive Cross-Clade Characterization of Antibody-Mediated Recognition, Complement-Mediated Lysis, and Cell-Mediated Cytotoxicity of HIV-1 Envelope-Specific Antibodies toward Eradication of the HIV-1 Reservoir
... ABSTRACT Immunotherapy with passive administration of broadly neutralizing HIV-1 envelope-specific antibodies (bnAbs) in the setting of established infection in vivo has yielded mixed results. The contribution of ...
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Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity
... correlation was also detected between Env levels and AUC values (Fig. 5E) by the Pearson correlation test (P ⫽ 0.0029). DISCUSSION Here, we show that disruption of the conserved membrane-prox- imal AP-2 binding site in ...
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Lysis of dengue virus-infected cells by natural cell-mediated cytotoxicity and antibody-dependent cell-mediated cytotoxicity.
... However, enhanced lysis of dengue-infected Raji cells by PBMC may not be due to the IFN produced, because neutralization of all IFN activity with anti-IFNa antibody did not decrease the [r] ...
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Inhibition of NK cell-mediated Cytotoxicity by Tubular Epithelial Cell Expression of Clr Proteins
... increased cytotoxicity against TEC lacking Clr-b/-f expression, highlighting that change in signalling from a single inhibitory Clr protein is not sufficient to affect NK cell activation against ...NK ...
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Human Monocyte Antibody Dependent Cell Mediated Cytotoxicity to Tumor Cells
... competing nonspecific monomeric immunoglobulin and by the ability of monocytes in “innocent bystander” experiments to lyse antibody-coated targets but not nonantibody- coated target cells. Evidence that monocytes were ...
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In vitro enhancement of human natural cell-mediated cytotoxicity by purified influenza virus glycoproteins.
... Natural killer cells are responsible for the interferon production induced in human lymphocytes by tumor cell contact. Antiviral activity induced by culturing lymphocytes with tumor- der[r] ...
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HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody- dependent cell-mediated cytotoxicity
... natural cytotoxicity were significantly lower than surface amounts of FcγRIIIa, which upon engagement by an antibody produced the strongest cytotoxic ...tumor cell binding and the low binding affinity to ...
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Cell-mediated cytotoxicity against targets bearing Sendai virus glycoproteins in the absence of viral infection.
... Ordinary P815 cells, P815 cells modified by the addition of glycoproteins, P815 cells infected with Sendai virus, and Yac-1 cells were used as targets.. After incubation at 37°C for 1 h,[r] ...
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