Cell Motility and Metastasis
Enhancing DPYSL3 gene expression via a promoter-targeted small activating RNA approach suppresses cancer cell motility and metastasis
... for metastasis-associated proteins using proteomics approach, we previously identified CRMP4 protein as a tumor metastasis suppressor in prostate cancers ...suppressed cell motility or ...
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Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling
... regulates cell migration and invasion via activation of Rac and matrix metalloproteinases ...regulating cell motility, invasion, and metastasis through activation of both ERK and PI3K ...
15
Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1
... HCC cell motility and metastasis in vitro and in vivo, we propose that aberrantly reduced PFN1 in advanced HCC plays a causal role in contributing to regional and distant ...
14
Lipopolysaccharide increases the release of VEGF-C that enhances cell motility and promotes lymphangiogenesis and lymphatic metastasis through the TLR4- NF-κB/JNK pathways in colorectal cancer
... and metastasis as well as the underlying ...node metastasis. LPS significantly enhanced cancer cell motility and promoted human dermal lymphatic endothelial cells’ (HDLECs’) capacity of tube- ...
14
Regulation of breast cancer cell motility by T cell lymphoma invasion and metastasis inducing protein
... in cell-based assays ...more-motile cell lines is associated with increased levels of activated Rac1, GST-based affinity precipitation assays were used to determine the relative levels of ...the cell ...
15
miR-17 regulates melanoma cell motility by inhibiting the translation of ETV1
... enhances cell motility, evident in both wound healing and transwell migration ...melanoma cell lines ETV1 knockdown by selective siRNA successfully pheno-copies the facilitated cell migration, ...
11
S100P enhances the motility and invasion of human trophoblast cell lines
... with metastasis and a poor patient ...corresponding cell lines in ...both cell motility and cellular invasion in different trophoblastic and first trimester EVT cell ...Interestingly, ...
18
Merkel Cell Polyomavirus Small T Antigen Mediates Microtubule Destabilization To Promote Cell Motility and Migration
... and cell motility and migration, essential factors for tumor cell ...Indeed metastasis to distant sites corre- lates with poor MCC survival rates ...of metastasis by virus oncoproteins ...
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The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
... cancer cell motility, tissue invasion, transendothelial migration and metastasis ...of cell adhesions, contact guidance, cytoskeletal reorganization, cell shape changes, secretion of ...
8
Screening by changes in stereotypical behavior during cell motility
... the cell lacks these landmark features, and finding constraints on cell shape is a non-trivial ...of cell behavior during ...in cell shape over timescales of ...
12
Rac and Rho GTPases in cancer cell motility control
... and metastasis or why its effects differ from ...cancer cell extravasation ...thereby metastasis dissemi- nation ...growth, cell migration and invasion and have proapoptotic functions in cells ...
14
Targets of miR 200c mediate suppression of cell motility and anoikis resistance
... squamous cell carcinoma [24] and basal breast cancer [23], a subtype with high risk of metastasis and recur- ...in cell migration through integrin binding [39] and can activate focal adhesion kinase ...
15
Virus-Induced Cell Motility
... and metastasis (16). The process of cell migration can be divided into three phases (16), each of which is mediated by a specific member of the rho subfamily of ras-related GTPases (2, ...the cell ...
9
Biology and Mechanism of Trypanosome Cell Motility
... Interestingly, loss of PFRA also causes mislocalization of PFRC, which is deposited in the distal tip of the mature fla- gellum (6). Further analysis of PFRA-deficient and PFR1 PFR2 mutants has provided important ...
9
Shape oscillations of human neutrophil leukocytes: characterization and relationship to cell motility
... their cell body over the immobile contacts (Felder and Kam, ...to cell ruffling, and concluded that ruffling and locomotion are controlled differentially and have distinct ...
7
Oriented cell motility and division underlie early limb bud morphogenesis
... that cell movement is a feature of limb formation only in lower vertebrates, and not in mouse or chick (Rallis et ...individual cell behaviours during early limb outgrowth in the mouse or chick has not ...
8
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility
... USP17 expression was also essential for chemokinesis, the migration of Hut78 T cells, either transfected with scrambled or USP17 shRNA1 bicistronic EGFP-expressing vectors, was examined. The cells were plated into wells ...
7
The cytohesin paralog Sec7 of Dictyostelium discoideum is required for phagocytosis and cell motility
... D. discoideum strains used were AX2, a Sec7 deficient strain derived from AX2 ( sec7 - ), and sec7 - expressing GFP- Sec7. They were grown in shaking suspension (160 rpm) in axenic medium at 22ºC or on a lawn of ...
17
Stimulation of glioma cell motility by expression, proteolysis, and release of the L1 neural cell recognition molecule
... No cell surface staining was evident even when using a 60× oil immersion objective lens ...robust cell surface L1 in live mouse L1-transfected quail QT6 cells even at low power ...
17
Eph/ephrin interactions modulate muscle satellite cell motility and patterning
... satellite cell response to physiological levels of native ephrins, we capitalized on two ephrin-mediated cell migration events in the developing quail embryo: emigration of cranial neural crest cells from ...
11