Cell-penetrating peptide
Enhancing siRNA-based cancer therapy using a new pH-responsive activatable cell-penetrating peptide-modified liposomal system
... activatable cell-penetrating peptide (ACPP) that is responsive to an acidic tumor microenvironment, which was then used to modify the surfaces of siRNA-loaded ...a cell-penetrating ...
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PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy
... modified cell penetrating peptide (CPP)-based gene ...(HS) cell targeting sequence fused to a CPP for improved membrane association and synergistically enhanced intracellular delivery of ...
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In vivo study of doxorubicin-loaded cell-penetrating peptide-modified pH-sensitive liposomes: biocompatibility, bio-distribution, and pharmacodynamics in BALB/c nude mice bearing human breast tumors
... novel cell-penetrating peptide (CPP)-modified pH-sensitive liposomes (CPPL) (referred to as CPPL(DOX)) with an opti- mal CPP density of ...more cell apoptosis as a result of DNA disruption as ...
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Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis
... synthesize peptide-drug conjugates in which the cell- penetrating peptide TAT (trans-activator of transcription) was conjugated to GA and evaluated the anti-cancer activity of this GA-CPP ...
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pH Responsive Triblock Copolymeric Micelles Decorated with a Cell Penetrating Peptide Provide Efficient Doxorubicin Delivery
... a cell-penetrating peptide, and proton sponge-triggered endosomal escape produced a robust pH-responsive drug delivery system with high efficacy, warranting further ...
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Enhancing cellular uptake of activable cell-penetrating peptide–doxorubicin conjugate by enzymatic cleavage
... activable cell-penetrating peptides (ACPPs) as molecular imaging probes is a promising new approach for the visualization of ...The cell-penetrating function of a polycationic ...
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A novel CAV derived cell-penetrating peptide efficiently delivers exogenous molecules through caveolae-mediated endocytosis
... Cell-penetrating peptide (CPP) is a promising cargo for delivering bioactive ...CVP1-FITC peptide could entry different types of cells tested with dose dependence, but without cytotoxic ...
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Intracellular delivery of cell-penetrating peptide-transcriptional factor fusion protein and its role in selective osteogenesis
... the cell-penetrating peptide-transcrip- tional cofactor fusion protein for clinical ...nontoxic cell-penetrating peptides and local release from such biomaterials as alginate ...
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The effect of dexamethasone/cell-penetrating peptide nanoparticles on gene delivery for inner ear therapy
... (Arg8) peptide shell for electrostatic complexation with nucleic acids (connexin 26 [Cx26] siRNA, green fluorescent protein [GFP] DNA or brain-derived neurotrophic factor [BDNF] ...a cell-penetrating ...
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Investigation of Cell-Penetrating Peptide Transformation in Two Regenerable Tissue Culture Systems
... With the availability of fully sequenced plant genomes there is more opportunity than ever to realize the potential of plant trait genetic modification. Traits important to agronomic growth, maturation, crop yield, and ...
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Synthesis, DNA-Binding and Antibacterial Activity of the Cell-Penetrating Peptide HIV-1 Tat (49-57)
... of cell-penetrating peptide human immunodeficiency virus transacting activator of transcription, peptide Tat (49-57), which is the minimal transduction domain of human immunodeficiency virus ...
7
Photodynamic therapy by conjugation of cell-penetrating peptide with fluorochrome
... photodynamic-induced cell death using SYTOX Blue and a fluorescence microscope (Figure 3C and ...the cell-implanted plate well, and images were taken on the boundary of the beam ...PDT-induced cell ...
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Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14
... hES cell pluri- potency and self-renewal [2, 8, 18, ...in cell morphology were clearly evident at 48 h and 72 h time points, when siOCT4-treated cells failed to form dense colonies characteristic to hES ...
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Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine
... result indicated that the NLCs clearly enhanced the absorp- tion of tripterine in the intestine, and this effect was especially improved when the particles were coated with the CPP. The low absorption of tripterine may ...
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A branched TAT cell-penetrating peptide as a novel delivery carrier for the efficient gene transfection
... the cell viability, while the PEI/pGFP complexes decreased the cell viability approximately 10 % at the N/P ratios of 15 and 20, indicating the high cell viability of the BTAT/pGFP complex was ...
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<p>Cell penetrating peptide-modified nanoparticles for tumor targeted imaging and synergistic effect of sonodynamic/HIFU therapy</p>
... F3 peptide is known for mediating dual-target- ing delivery to speci fi c tumor cells and tumor angiogenesis by selectively binding to nucleolin, which is expressed on the surface of tumor cells and tumor ...
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Identification of a cell-penetrating peptide domain from human beta-defensin 3 and characterization of its anti-inflammatory activity
... hBD3 peptide fragments to penetrate the outer membrane of cells, as well as mouse ...mismatch peptide of ...quantified peptide internalization via flow cytometry to more accurately evaluate ...
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A Cell Penetrating Peptide for Inhibiting MAPKAP Kinase 2 Mediated Inflammatory Cytokine Release Following Glial Cell Activation
... neuronal cell damage after microglial activation in ...cortical cell viability (Figure 3) coupled with the images of the neural population (Figure 6) suggest that there is a neu- ronal protective effect to ...
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<p>Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo</p>
... trials. Cell-penetrating peptides (CPPs), consisting of a class of highly effective short peptides, are able to penetrate cell membranes and transport different components into cells with high ...
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<p>Enhanced Efficacy of Photodynamic Therapy by Coupling a Cell-Penetrating Peptide with Methylene Blue</p>
... Cell viability was tested up to 3 days after PDT in HT- 29 cells using the MTT assay. The wavelength of the radiation source for PDT was 540/550 nm, selected by a single-band filter. The wavelength was selected ...
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