Cell-penetrating peptide (CPP)
Enhancing siRNA-based cancer therapy using a new pH-responsive activatable cell-penetrating peptide-modified liposomal system
... activatable cell-penetrating peptide (ACPP) that is responsive to an acidic tumor microenvironment, which was then used to modify the surfaces of siRNA-loaded ...a cell-penetrating ...
21
PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy
... modified cell penetrating peptide (CPP)-based gene ...(HS) cell targeting sequence fused to a CPP for improved membrane association and synergistically enhanced intracellular delivery of ...
11
In vivo study of doxorubicin-loaded cell-penetrating peptide-modified pH-sensitive liposomes: biocompatibility, bio-distribution, and pharmacodynamics in BALB/c nude mice bearing human breast tumors
... novel cell-penetrating peptide (CPP)-modified pH-sensitive liposomes (CPPL) (referred to as CPPL(DOX)) with an opti- mal CPP density of ...more cell apoptosis as a result of DNA disruption as ...
13
Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis
... synthesize peptide-drug conjugates in which the cell- penetrating peptide TAT (trans-activator of transcription) was conjugated to GA and evaluated the anti-cancer activity of this GA-CPP ...
14
Enhancing cellular uptake of activable cell-penetrating peptide–doxorubicin conjugate by enzymatic cleavage
... activable cell-penetrating peptides (ACPPs) as molecular imaging probes is a promising new approach for the visualization of ...The cell-penetrating function of a polycationic ...
9
A novel CAV derived cell-penetrating peptide efficiently delivers exogenous molecules through caveolae-mediated endocytosis
... Cell-penetrating peptide (CPP) is a promising cargo for delivering bioactive ...CVP1-FITC peptide could entry different types of cells tested with dose dependence, but without cytotoxic ...
9
Investigation of Cell-Penetrating Peptide Transformation in Two Regenerable Tissue Culture Systems
... With the availability of fully sequenced plant genomes there is more opportunity than ever to realize the potential of plant trait genetic modification. Traits important to agronomic growth, maturation, crop yield, and ...
91
pH Responsive Triblock Copolymeric Micelles Decorated with a Cell Penetrating Peptide Provide Efficient Doxorubicin Delivery
... cationic peptide, poly- L -arginine (pArg), is a cell- penetrating peptide that translocates through cell mem- branes and facilitates cellular ...through cell membranes ...
13
Intracellular delivery of cell-penetrating peptide-transcriptional factor fusion protein and its role in selective osteogenesis
... arginine-rich cell-penetrating peptide, termed low-molecular-weight protamine (LMWP), and a transcriptional coactivator with a PDZ-binding motif (TAZ) protein was prepared and applied in combination ...
14
Synthesis, DNA-Binding and Antibacterial Activity of the Cell-Penetrating Peptide HIV-1 Tat (49-57)
... of cell-penetrating peptide human immunodeficiency virus transacting activator of transcription, peptide Tat (49-57), which is the minimal transduction domain of human immunodeficiency virus ...
7
The effect of dexamethasone/cell-penetrating peptide nanoparticles on gene delivery for inner ear therapy
... (Arg8) peptide shell for electrostatic complexation with nucleic acids (connexin 26 [Cx26] siRNA, green fluorescent protein [GFP] DNA or brain-derived neurotrophic factor [BDNF] ...a cell-penetrating ...
12
The Telomerase-Derived Anticancer Peptide Vaccine GV1001 as an Extracellular Heat Shock Protein-Mediated Cell-Penetrating Peptide
... Abstract: Cell-penetrating peptides (CPPs), a group of small peptides capable of promoting the transport of molecular cargo across the plasma membrane, have become important tools in promoting the cellular ...
7
Designing and enhancing the antifungal activity of corneal specific cell penetrating peptide using gelatin hydrogel delivery system
... We downloaded the entire protein dataset of Fusarium solani from the FTP site of NCBI database to design CPP which can penetrate both corneal epithelium and F. solani. This served as our dataset 6. Further comparisons of ...
18
<p>Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo</p>
... when the ratio was .4:1 and the effective binding ratio of siGFP to TP is 16:1. Here, we did not know the bind- ing mechanism of T9(dR) and siRNA. Nevertheless, we hypothesized that it might be related to the charge and ...
10
A Cell Penetrating Peptide for Inhibiting MAPKAP Kinase 2 Mediated Inflammatory Cytokine Release Following Glial Cell Activation
... The peptide sequence, KKKALNRQLGVAA, was identified as a substrate-based inhibitor of MK2 in vitro ...[28]. Cell-penetrating peptides (CPPs) have also been studied as a mechanism for delivering ...
16
A branched TAT cell-penetrating peptide as a novel delivery carrier for the efficient gene transfection
... Although natural CPPs can penetrate into the cells without toxicity, transfection efficiency is too low to achieve expected therapeutic effects due to their low- molecular-weight, unstable linear structure and weak gene ...
8
Effect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine
... result indicated that the NLCs clearly enhanced the absorp- tion of tripterine in the intestine, and this effect was especially improved when the particles were coated with the CPP. The low absorption of tripterine may ...
11
Antitumor activity of tripterine via cell-penetrating peptide-coated nanostructured lipid carriers in a prostate cancer model
... NLC, would be maintained at a constant concentration for a relatively long period in vivo, thereby having consistent antitumor efficacy. Further, Ste-R 6 L 2 (a type of CPP com- posed mainly of arginine and leucine) ...
12
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers
... novel cell-penetrating peptide (CPP) for ocular delivery of small and large molecules, including siRNA, fluorescent probes, plasmid DNA and quantum dots to RPE, photoreceptor and ganglion cells in ...
16
<p>Enhanced Efficacy of Photodynamic Therapy by Coupling a Cell-Penetrating Peptide with Methylene Blue</p>
... significant cell death after treat- ment with 10 µM for MB and MB-Pro compared with the negative control subgroup (MB 0 ...The cell viability of PDT with MB-Pro was ...in cell viabilities for MB and ...
9